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Title: | Periodized versus classic exercise therapy in Multiple Sclerosis: a randomized controlled trial | Authors: | KEYTSMAN, Charly VAN NOTEN, Pieter VERBOVEN, Kenneth VAN ASCH, Paul OP 'T EIJNDE, Bert |
Issue Date: | 2021 | Publisher: | ELSEVIER SCI LTD | Source: | Multiple Sclerosis and Related Disorders, 49 , (Art N° 102782) | Abstract: | Background: Periodizing exercise interventions in Multiple Sclerosis (MS) shows good high intensity exercise training adherence. Whether this approach induces comparable training adaptations with respect to exercise capacity, body composition and muscle strength compared to conventional, linear progressive training programs however is not known. Methods: Thirty-one persons with MS (all phenotypes, mean EDSS 2.3?1.3) were randomized into a twelve-week periodized (MSPER, n=17) or a classic endurance (MSCLA, n=14) training program. At baseline (PRE), exercise capacity (maximal exercise test, VO2max), body composition (DEXA) and muscle strength (Biodex?) were assessed. Classic, moderate intensity endurance training (60-80% HRmax, 5 training sessions/2w, 60min/session) was performed on a stationary bicycle. Periodized exercise included 4 recurrent 3-week cycles of alternated endurance training (week 1: endurance training as described above), high intense exercise (week 2: 3 sessions/w, 3 ? 20s all-out sprints, 10min/session) and recovery weeks (week 3: one sprint session as described above). POST measurements were performed similar to baseline. Total exercise volume of both programs was expressed as total peak-effort training minutes. Results: For MSCLA, total exercise volume included 1728 total peak-effort training minutes, whereas MSPER included only 736. Despite this substantially reduced training volume, twelve weeks of periodized training significantly (p<0.05) improved VO2max (+14%, p=0.001), workload (+20%) and time until exhaustion (+25%). Classic training significantly (p<0.05) improved workload (+10%) and time until exhaustion (+17%), but not VO2max (+5%, p=0.131). Pre-post improvements for VO2max were significantly higher in MSPER compared to MSCLA (p=0.046). Conclusion: These data show that despite substantially lower training time (57% less peak-effort training minutes), 12 weeks of periodized exercise training in persons with MS seems to induce larger improvements in parameters of exercise capacity compared to classic endurance training. We therefore recommend to further investigate the effect of training periodization on various functional rehabilitation measures in MS. | Notes: | Keytsman, C (corresponding author), Hasselt Univ, REVAL Rehabil Ctr, Biomed Res Inst BIOMED, Agoralaan Bldg A, B-3590 Diepenbeek, Belgium. charly.keytsman@uhasselt.be |
Other: | Keytsman, C (corresponding author), Hasselt Univ, REVAL Rehabil Ctr, Biomed Res Inst BIOMED, Agoralaan Bldg A, B-3590 Diepenbeek, Belgium. charly.keytsman@uhasselt.be | Keywords: | Multiple sclerosis;Rehabilitation;High intensity interval training;Periodisation | Document URI: | http://hdl.handle.net/1942/34226 | ISSN: | 2211-0348 | e-ISSN: | 2211-0356 | DOI: | 10.1016/j.msard.2021.102782 | ISI #: | WOS:000641392000007 | Rights: | 2021 Elsevier B.V. All rights reserved. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2022 |
Appears in Collections: | Research publications |
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