Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/34255
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dc.contributor.authorVaes, Anouk-
dc.contributor.authorGoërtz, Yvonne-
dc.contributor.authorVAN HERCK, Maarten-
dc.contributor.authorMachado, Felipe-
dc.contributor.authorMeys, Roy-
dc.contributor.authorDelbressine, Jeannet-
dc.contributor.authorHouben-Wilke, Sarah-
dc.contributor.authorGaffron, Swetlana-
dc.contributor.authorMaier, Dieter-
dc.contributor.authorBURTIN, Chris-
dc.contributor.authorPosthuma, Rein-
dc.contributor.authorVan Loon, Nicole-
dc.contributor.authorFranssen, Frits-
dc.contributor.authorHajian, Bita-
dc.contributor.authorSimons, Sami-
dc.contributor.authorVan Boven, Job-
dc.contributor.authorKlok, Frederikus-
dc.contributor.authorSpaetgens, Bart-
dc.contributor.authorPinxt, Claire-
dc.contributor.authorLiu, Limmie-
dc.contributor.authorWesseling, Geertjan-
dc.contributor.authorSpies, Yvonne-
dc.contributor.authorVijlbrief, Herman-
dc.contributor.authorVan 't Hul, Alex-
dc.contributor.authorJanssen, Daisy-
dc.contributor.authorSPRUIT, Martijn A.-
dc.date.accessioned2021-06-08T09:27:47Z-
dc.date.available2021-06-08T09:27:47Z-
dc.date.issued2021-
dc.date.submitted2021-06-04T06:45:14Z-
dc.identifier.citationERJ open research, 7 (2) (Art N° 00141-2021)-
dc.identifier.urihttp://hdl.handle.net/1942/34255-
dc.description.abstractBackground: It remains unknown whether and to what extent members of online "long COVID" peer support groups remain symptomatic and limited over time. Therefore, we aimed to evaluate symptoms in members of online long COVID peer support groups up to 6 months after the onset of coronavirus disease 2019 (COVID-19)-related symptoms. Methods: Demographics, symptoms, health status, work productivity, functional status and health-related quality of life were assessed about 3 and 6 months after the onset of COVID-19-related symptoms in members of online long COVID peer support groups. Results: Data from 239 patients with a confirmed COVID-19 diagnosis (83% women; median (interquartile range) age 50 (39-56) years) were analysed. During the infection, a median (interquartile range) of 15 (11-18) symptoms was reported, which was significantly lower 3 and 6 months later: 6 (4-9) and 6 (3-8), respectively (p<0.05). From 3 to 6 months follow-up, the proportion of patients without symptoms increased from 1.3% to only 5.4% (p<0.001). Patients also reported a significantly improved work productivity (work absenteeism and presenteeism: 73% versus 52% and 66% versus 60%, respectively), self-reported good health (9.2% versus 16.7%), functional status (mean±SD Post-COVID-19 Functional Status scale: 2.4±0.9 versus 2.2±1.0) and health-related quality of life (all p<0.05). Conclusion: Although patients with confirmed COVID-19, who were all members of online long COVID peer support groups, reported significant improvements in work productivity, functional status and quality of life between 3 and 6 months follow-up, these data clearly highlight the long-term impact of COVID-19, as approximately 6 months after the onset of COVID-19-related symptoms a large proportion still experienced persistent symptoms, a moderate-to-poor health, moderate-to-severe functional limitations, considerable loss in work productivity, and/or an impaired quality of life. Action is needed to improve the management and healthcare of these patients.-
dc.description.sponsorshipThe research team acknowledges the valuable input from the patient representatives to develop the survey, and the technical support by Martijn Briejers and Oscar Wagemakers (ASolutions, Capelle aan den Ijssel, The Netherlands).-
dc.language.isoen-
dc.publisherEuropean Respiratory Society-
dc.rightsCopyright ©The authors 2021. This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org-
dc.titleRecovery from COVID-19: a sprint or marathon? 6-month follow-up data from online long COVID-19 support group members-
dc.typeJournal Contribution-
dc.identifier.issue2-
dc.identifier.volume7-
local.bibliographicCitation.jcatA1-
local.publisher.place442 GLOSSOP RD, SHEFFIELD S10 2PX, ENGLAND-
dc.relation.referencesGoërtz YMJ, Van Herck M, Delbressine JM, et al. Persistent symptoms 3 months after a SARS-CoV-2 infection: the post-COVID-19 syndrome? ERJ Open Res 2020; 6: 00542-2020. 2 Carfì A, Bernabei R, Landi F. Persistent symptoms in patients after acute COVID-19. JAMA 2020; 324: 603–605. 3 Greenhalgh T, Knight M, A’Court C, et al. Management of post-acute COVID-19 in primary care. BMJ 2020; 370: m3026. 4 Wong AW, Shah AS, Johnston JC, et al. Patient-reported outcome measures after COVID-19: a prospective cohort study. Eur Respir J 2020; 56: 2003276. 5 D’Cruz RF, Waller MD, Perrin F, et al. Chest radiography is a poor predictor of respiratory symptoms and functional impairment in survivors of severe COVID-19 pneumonia. ERJ Open Res 2021; 7: 00655-2020. 6 Sudre CH, Murray B, Varsavsky T, et al. Attributes and predictors of Long-COVID: analysis of COVID cases and their symptoms collected by the Covid Symptoms Study App. medRxiv 2020; preprint [https://doi.org/10.1101/ 2020.10.19.20214494]. 7 Huang C, Huang L, Wang Y, et al. 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study. Lancet 2021; 397: 220–232. 8 Stavem K, Ghanima W, Olsen MK, et al. Persistent symptoms 1.5-6 months after COVID-19 in non-hospitalised subjects: a population-based cohort study. Thorax 2021; 76: 405–407. 9 Petersen MS, Kristiansen MF, Hanusson KD, et al. Long COVID in the Faroe Islands – a longitudinal study among non-hospitalized patients. Clin Infect Dis 2020; in press [https://doi.org/10.1093/cid/ciaa1792]. 10 Vaes AW, Machado FVC, Meys R, et al. Care dependency in non-hospitalized patients with COVID-19. J Clin Med 2020; 9: 2946. 11 van den Borst B, Peters JB, Brink M, et al. Comprehensive health assessment three months after recovery from acute COVID-19. Clin Infect Dis 2020; in press [https://doi.org/10.1093/cid/ciaa1750]. 12 Perego E, Callard F, Stras L, et al. Why the Patient-Made Term ‘Long Covid’ is needed. Wellcome Open Res 2020;5: 224. 13 National Institue for Health and Care Excellence. COVID-19 guideline: management of the long-term effects of COVID-19. www.nice.org.uk/guidance/gid-ng10179/documents/final-scope Date last updated: 19 October 2020; date last accessed: 2 March 2021. 14 Tenforde MW, Kim SS, Lindsell CJ, et al. Symptom duration and risk factors for delayed return to usual health among outpatients with COVID-19 in a multistate health care systems network - United States, March-June 2020. MMWR Morb Mortal Wkly Rep 2020; 69: 993–998. 15 Ladds E, Rushforth A, Wieringa S, et al. Persistent symptoms after Covid-19: qualitative study of 114 long Covid patients and draft quality criteria for services. medRxiv 2020; preprint [https://doi.org/10.1101/2020.10.13. 20211854]. 16 Assaf G, Davis H, McCorkell L, et al. An analysis of the prolonged COVID-19 symptoms survey by patient-led research team. 2020. https://patientresearchcovid19.com/research/report-1/ Date last updated: 11 May 2020; date last accessed: 15 November 2020. 17 Reilly MC, Zbrozek AS, Dukes EM. The validity and reproducibility of a work productivity and activity impairment instrument. Pharmacoeconomics 1993; 4: 353–365. 18 Brakema EA, Tabyshova A, van der Kleij R, et al. The socioeconomic burden of chronic lung disease in low-resource settings across the globe - an observational FRESH AIR study. Respir Res 2019; 20: 291. 19 Klok FA, Boon GJAM, Barco S, et al. The Post-COVID-19 Functional Status (PCFS) Scale: a tool to measure functional status over time after COVID-19. Eur Respir J 2020; 56: 2001494. 20 Machado FVC, Meys R, Delbressine JM, et al. Construct validity of the Post-COVID-19 Functional Status Scale in adult subjects with COVID-19. Health Qual Life Outcomes 2021; 19: 40. 21 Versteegh MM, Vermeulen KM, Evers SMAA, et al. Dutch tariff for the five-level version of EQ-5D. Value in health: the journal of the International Society for Pharmacoeconomics and Outcomes. Research 2016; 19: 343–352. 22 EQ-5D. https://euroqol.org/eq-5d-instruments/eq-5d-5l-about 23 Grochtdreis T, Dams J, Konig HH, et al. Health-related quality of life measured with the EQ-5D-5L: estimation of normative index values based on a representative German population sample and value set. Eur J Health Econ 2019; 20: 933–944. 24 Woloshin S, Patel N, Kesselheim AS. False negative tests for SARS-CoV-2 infection - challenges and implications. N Engl J Med 2020; 383: e38. 25 Kamdar BB, Suri R, Suchyta MR, et al. Return to work after critical illness: a systematic review and meta-analysis. Thorax 2020; 75: 17–27. 26 Gavriatopoulou M, Korompoki E, Fotiou D, et al. Organ-specific manifestations of COVID-19 infection. Clin Exp Med 2020; 20: 493–506. 27 Gupta A, Madhavan MV, Sehgal K, et al. Extrapulmonary manifestations of COVID-19. Nat Med 2020; 26: 1017–1032. 28 Davido B, Seang S, Tubiana R, et al. Post-COVID-19 chronic symptoms: a postinfectious entity? Clin Microbiol Infect 2020; 26: 1448–1449. 29 Cirulli ET, Schiabor Barrett KM, Riffle S, et al. Long-term COVID-19 symptoms in a large unselected population. medRxiv 2020; preprint [https://doi.org/10.1101/2020.10.07.20208702]. 30 Chen J, Wu J, Hao S, et al. Long term outcomes in survivors of epidemic Influenza A (H7N9) virus infection. Sci Rep 2017; 7: 17275. 31 Herridge MS. Recovery and long-term outcome in acute respiratory distress syndrome. Crit Care Clin 2011; 27: 685–704. 32 Hopkins RO, Weaver LK, Collingridge D, et al. Two-year cognitive, emotional, and quality-of-life outcomes in acute respiratory distress syndrome. Am J Respir Crit Care Med 2005; 171: 340–347.-
local.type.refereedRefereed-
local.type.specifiedArticle-
local.bibliographicCitation.artnr00141-2021-
dc.identifier.doi10.1183/23120541.00141-2021-
dc.identifier.pmid34041295-
dc.identifier.isiWOS:000684169700016-
dc.identifier.eissn2312-0541-
local.provider.typePdf-
local.uhasselt.uhpubyes-
local.dataset.citationMETC2020-1978, METC2020-2554, and MEC2020/041-
local.uhasselt.internationalyes-
item.accessRightsOpen Access-
item.validationecoom 2023-
item.contributorVaes, Anouk-
item.contributorGoërtz, Yvonne-
item.contributorVAN HERCK, Maarten-
item.contributorMachado, Felipe-
item.contributorMeys, Roy-
item.contributorDelbressine, Jeannet-
item.contributorHouben-Wilke, Sarah-
item.contributorGaffron, Swetlana-
item.contributorMaier, Dieter-
item.contributorBURTIN, Chris-
item.contributorPosthuma, Rein-
item.contributorVan Loon, Nicole-
item.contributorFranssen, Frits-
item.contributorHajian, Bita-
item.contributorSimons, Sami-
item.contributorVan Boven, Job-
item.contributorKlok, Frederikus-
item.contributorSpaetgens, Bart-
item.contributorPinxt, Claire-
item.contributorLiu, Limmie-
item.contributorWesseling, Geertjan-
item.contributorSpies, Yvonne-
item.contributorVijlbrief, Herman-
item.contributorVan 't Hul, Alex-
item.contributorJanssen, Daisy-
item.contributorSPRUIT, Martijn A.-
item.fulltextWith Fulltext-
item.fullcitationVaes, Anouk; Goërtz, Yvonne; VAN HERCK, Maarten; Machado, Felipe; Meys, Roy; Delbressine, Jeannet; Houben-Wilke, Sarah; Gaffron, Swetlana; Maier, Dieter; BURTIN, Chris; Posthuma, Rein; Van Loon, Nicole; Franssen, Frits; Hajian, Bita; Simons, Sami; Van Boven, Job; Klok, Frederikus; Spaetgens, Bart; Pinxt, Claire; Liu, Limmie; Wesseling, Geertjan; Spies, Yvonne; Vijlbrief, Herman; Van 't Hul, Alex; Janssen, Daisy & SPRUIT, Martijn A. (2021) Recovery from COVID-19: a sprint or marathon? 6-month follow-up data from online long COVID-19 support group members. In: ERJ open research, 7 (2) (Art N° 00141-2021).-
crisitem.journal.issn2312-0541-
crisitem.journal.eissn2312-0541-
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