Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/34287
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dc.contributor.authorPENG, Qiyao-
dc.contributor.authorVERMOLEN, Fred-
dc.contributor.authorWeihs, D-
dc.date.accessioned2021-06-18T12:55:21Z-
dc.date.available2021-06-18T12:55:21Z-
dc.date.issued2021-
dc.date.submitted2021-06-17T14:36:10Z-
dc.identifier.citationBiomechanics and Modeling in Mechanobiology, 20 (4), p. 1459-1475-
dc.identifier.issn1617-7959-
dc.identifier.urihttp://hdl.handle.net/1942/34287-
dc.description.abstractThe phenomenological model for cell shape deformation and cell migration Chen (BMM 17:1429-1450, 2018), Vermolen and Gefen (BMM 12:301-323, 2012), is extended with the incorporation of cell traction forces and the evolution of cell equilibrium shapes as a result of cell differentiation. Plastic deformations of the extracellular matrix are modelled using morphoelasticity theory. The resulting partial differential differential equations are solved by the use of the finite element method. The paper treats various biological scenarios that entail cell migration and cell shape evolution. The experimental observations in Mak et al. (LC 13:340-348, 2013), where transmigration of cancer cells through narrow apertures is studied, are reproduced using a Monte Carlo framework.-
dc.description.sponsorshipThe authors appreciate China Scholarship Council (CSC) for the fnancial support for this project. The work was partially supported by the Israeli Ministry of Science and Technology (MOST) Medical Devices Program (Grant no. 3-17427 awarded to Prof. Daphne Weihs).-
dc.language.isoen-
dc.publisherSPRINGER HEIDELBERG-
dc.rightsOpen Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.-
dc.subject.otherCell geometry-
dc.subject.otherCell migration-
dc.subject.otherCellular traction forces-
dc.subject.otherFinite-element method-
dc.subject.otherAgent-based modelling-
dc.titleA formalism for modelling traction forces and cell shape evolution during cell migration in various biomedical processes-
dc.typeJournal Contribution-
dc.identifier.epage1475-
dc.identifier.issue4-
dc.identifier.spage1459-
dc.identifier.volume20-
local.format.pages17-
local.bibliographicCitation.jcatA1-
local.contributor.corpauthorQiyao Peng, Daphne Weihs, Fred Vermolen-
local.publisher.placeTIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY-
local.type.refereedRefereed-
local.type.specifiedArticle-
dc.identifier.doi10.1007/s10237-021-01456-2-
dc.identifier.pmid33893558-
dc.identifier.isiWOS:000642846400001-
dc.identifier.eissn1617-7940-
local.provider.typePdf-
local.uhasselt.uhpubyes-
local.uhasselt.internationalyes-
item.contributorPENG, Qiyao-
item.contributorVERMOLEN, Fred-
item.contributorWeihs, D-
item.fullcitationPENG, Qiyao; VERMOLEN, Fred & Weihs, D (2021) A formalism for modelling traction forces and cell shape evolution during cell migration in various biomedical processes. In: Biomechanics and Modeling in Mechanobiology, 20 (4), p. 1459-1475.-
item.accessRightsOpen Access-
item.fulltextWith Fulltext-
item.validationecoom 2022-
crisitem.journal.issn1617-7959-
crisitem.journal.eissn1617-7940-
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