Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/34335
Title: | Paternal body mass index and offspring DNA methylation: findings from the PACE consortium | Authors: | Sharp, Gemma C ALFANO, Rossella Ghantous, Akram Urquiza, Jose Rifas-Shiman, Sheryl L Page, Christian M Jin, Jianping Fernández-Barrés, Silvia Santorelli, Gillian Tindula, Gwen |
Corporate Authors: | Pregnancy and Childhood Epigenetics (PACE) consortium | Issue Date: | 2021 | Publisher: | OXFORD UNIV PRESS | Source: | INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 50(4), p. 1297-1315 | Abstract: | Background Accumulating evidence links paternal adiposity in the periconceptional period to offspring health outcomes. DNA methylation has been proposed as a mediating mechanism, but very few studies have explored this possibility in humans. Methods In the Pregnancy And Childhood Epigenetics (PACE) consortium, we conducted a meta-analysis of coordinated epigenome-wide association studies (EWAS) of paternal prenatal body mass index (BMI) (with and without adjustment for maternal BMI) in relation to DNA methylation in offspring blood at birth (13 data sets; total n = 4894) and in childhood (6 data sets; total n = 1982). Results We found little evidence of an association at either time point: at all CpGs, the false-discovery-rate-adjusted P-values were >0.05. In secondary sex-stratified analyses, we found just four CpGs for which there was robust evidence of an association in female offspring. To compare our findings to those of other studies, we conducted a systematic review, which identified seven studies, including five candidate gene studies showing associations between paternal BMI/obesity and offspring or sperm DNA methylation at imprinted regions. However, in our own study, we found very little evidence of enrichment for imprinted genes. Conclusion Our findings do not support the hypothesis that paternal BMI around the time of pregnancy is associated with offspring-blood DNA methylation, even at imprinted regions. | Keywords: | DNA methylation;DOHaD;Paternal;body mass index;epigenetics;fathers;pregnancy | Document URI: | http://hdl.handle.net/1942/34335 | ISSN: | 0300-5771 | e-ISSN: | 1464-3685 | DOI: | 10.1093/ije/dyaa267 | ISI #: | 000705268900030 | Rights: | The Author(s) 2021. Published by Oxford University Press on behalf of the International Epidemiological Association. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2022 |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
dyaa267.pdf | Published version | 814.99 kB | Adobe PDF | View/Open |
WEB OF SCIENCETM
Citations
12
checked on Aug 3, 2024
Page view(s)
24
checked on Sep 7, 2022
Download(s)
22
checked on Sep 7, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.