Please use this identifier to cite or link to this item:
Title: A one-dimensional morphoelastic model for burn injuries: sensitivity analysis and a feasibility study
Authors: EGBERTS, Ginger 
Van Zuijlen, Paul
Issue Date: 2021
Abstract: We consider a one-dimensional morphoelastic model describing post-burn scar contraction. This model describes the displacement of the dermal layer of the skin and the development of the effective Eulerian strain in the tissue. Besides these components, the model also contains components that play a major role in skin repair after trauma. These components are signaling molecules, fibroblasts, myofi-broblasts, and collagen. We perform a sensitivity analysis for many parameters of the model and use the results for a feasibility study. In this study, we test whether the model is suitable for predicting the extent of contraction in different age groups. To this end, we conduct an extensive literature review to find parameter values. From the sensitivity analysis, we conclude that the most sensitive parameters are the equilibrium collagen concentration in the dermal layer, the apoptosis rate of fi-broblasts and myofibroblasts, and the secretion rate of signaling molecules. Further, although we can use the model to simulate distinct contraction densities in different age groups, our results differ from what is seen in the clinic.
Keywords: Mathematics - Numerical Analysis;Computer Science - Numerical Analysis;Physics - Biological Physics;Quantitative Biology - Tissues and Organs
Document URI:
Link to publication/dataset:
Category: O
Type: Preprint
Appears in Collections:Research publications

Files in This Item:
File Description SizeFormat 
2010.12902.pdfNon Peer-reviewed author version6.11 MBAdobe PDFView/Open
Show full item record

Page view(s)

checked on Sep 7, 2022

Google ScholarTM


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.