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http://hdl.handle.net/1942/34359
Title: | A one-dimensional morphoelastic model for burn injuries: sensitivity analysis and a feasibility study | Authors: | EGBERTS, Ginger VERMOLEN, Fred Van Zuijlen, Paul |
Issue Date: | 2021 | Abstract: | We consider a one-dimensional morphoelastic model describing post-burn scar contraction. This model describes the displacement of the dermal layer of the skin and the development of the effective Eulerian strain in the tissue. Besides these components, the model also contains components that play a major role in skin repair after trauma. These components are signaling molecules, fibroblasts, myofi-broblasts, and collagen. We perform a sensitivity analysis for many parameters of the model and use the results for a feasibility study. In this study, we test whether the model is suitable for predicting the extent of contraction in different age groups. To this end, we conduct an extensive literature review to find parameter values. From the sensitivity analysis, we conclude that the most sensitive parameters are the equilibrium collagen concentration in the dermal layer, the apoptosis rate of fi-broblasts and myofibroblasts, and the secretion rate of signaling molecules. Further, although we can use the model to simulate distinct contraction densities in different age groups, our results differ from what is seen in the clinic. | Keywords: | Mathematics - Numerical Analysis;Computer Science - Numerical Analysis;Physics - Biological Physics;Quantitative Biology - Tissues and Organs | Document URI: | http://hdl.handle.net/1942/34359 | Link to publication/dataset: | http://arxiv.org/abs/2010.12902v3 | Category: | O | Type: | Preprint |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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2010.12902.pdf | Non Peer-reviewed author version | 6.11 MB | Adobe PDF | View/Open |
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