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http://hdl.handle.net/1942/3446
Title: | Immunosuppressors inhibit voltage-gated potassium channels in human peripheral blood lymphocytes | Authors: | Panyi, G Gaspar, R Krasznai, Z ter Horst, JJ AMELOOT, Marcel Aszalos, A. STEELS, Paul Damjanovich, S |
Issue Date: | 1996 | Publisher: | ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS | Source: | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 221(2). p. 254-258 | Abstract: | The effects of immunosuppressive agents on the potassium current of human peripheral blood lymphocytes have been studied using the whole-cell patch-clamp technique. Cyclosporin A(10 mu g/ml), rapamycin (10 mu g/ml) and FK-506 (2.5 mu g/ml) reduced the peak K+ current by approximately 40, 30 and 40% of the control, respectively, without any change in the reversal potential of the current. The current inhibition was similar at all membrane potentials studied and was accompanied with an increase in the rate of K+ current inactivation Membrane potential measurements in current-clamp showed a marked depolarization of the membrane (>10 mV) upon the addition of either immunosuppressor to the cells. Our findings revealed that the voltage-dependent potassium current in human peripheral blood lymphocytes is inhibited by Cyclosporin A and other immunosuppressors, resulting in a depolarized membrane potential. (C) 1996 Academic Press, Inc. | Notes: | DEBRECEN UNIV MED,SCH MED,DEPT BIOPHYS,H-4102 DEBRECEN,HUNGARY. LIMBURGS UNIV CENTRUM,DEPT PHYSIOL,DIEPENBEEK,BELGIUM. US FDA,DIV RES & TESTING,WASHINGTON,DC 20204. | Document URI: | http://hdl.handle.net/1942/3446 | DOI: | 10.1006/bbrc.1996.0582 | ISI #: | A1996UF91100008 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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