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http://hdl.handle.net/1942/34481
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DC Field | Value | Language |
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dc.contributor.author | Franzone, Anna | - |
dc.contributor.author | McFadden, Eugène P. | - |
dc.contributor.author | Leonardi, Sergio | - |
dc.contributor.author | Piccolo, Raffaele | - |
dc.contributor.author | VRANCKX, Pascal | - |
dc.contributor.author | Serruys, Patrick W. | - |
dc.contributor.author | Hamm, Christian | - |
dc.contributor.author | Steg, Philippe Gabriel | - |
dc.contributor.author | Heg, Dik | - |
dc.contributor.author | Branca, Mattia | - |
dc.contributor.author | Jüni, Peter | - |
dc.contributor.author | Windecker, Stephan | - |
dc.contributor.author | Valgimigli, Marco | - |
dc.date.accessioned | 2021-07-15T11:54:05Z | - |
dc.date.available | 2021-07-15T11:54:05Z | - |
dc.date.issued | 2020 | - |
dc.date.submitted | 2021-07-08T09:10:48Z | - |
dc.identifier.citation | EuroIntervention, 16 (8) , p. 627 -633 | - |
dc.identifier.uri | http://hdl.handle.net/1942/34481 | - |
dc.description.abstract | Aims: The aim of this study was to investigate the effect of ticagrelor monotherapy after one-month dual antiplatelet therapy (DAPT) or conventional DAPT in patients with or without acute coronary syndrome (ACS) in the GLOBAL LEADERS Adjudication Sub-StudY (GLASSY). Methods and results: Risk estimates were expressed as rate ratios (RR) with 95% confidence intervals (CI). A total of 3,840 ACS and 3,745 stable ischaemic heart disease (SIHD) patients were included. At two years, rates of the co-primary efficacy endpoint, a composite of death, myocardial infarction, stroke or urgent target vessel revascularisation, were 7.94% in the experimental and 9.68% in the control group (RR 0.82, 95% CI: 0.66-1.01) among ACS patients and 6.31% in the experimental and 7.14% in the control group (RR 0.89, 95% CI: 0.69-1.13) among SIHD patients (p(int)=0.63). Trends for lower and higher risk of BARC 3 or 5 bleeding with the experimental strategy in ACS (2.27% vs 3.00%, RR 0.76, 95% CI: 0.51-1.12) and SIHD (2.70% vs 1.96%, RR 1.39, 95% CI: 0.91-2.12) patients, respectively, were observed with significant interaction testing (p(int)=0.039). A net clinical benefit endpoint, the composite of both co-primary study endpoints, favoured the experimental treatment among ACS patients only. Conclusions: Ticagrelor monotherapy after one-month DAPT provided consistent treatment effects on ischaemic endpoints in patients with or without ACS but only the former experienced a net clinical benefit. | - |
dc.language.iso | en | - |
dc.publisher | - | |
dc.title | Ticagrelor alone or conventional dual antiplatelet therapy in patients with stable or acute coronary syndromes | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 633 | - |
dc.identifier.issue | 8 | - |
dc.identifier.spage | 627 | - |
dc.identifier.volume | 16 | - |
local.bibliographicCitation.jcat | A1 | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.4244/EIJ-D-20-00145 | - |
dc.identifier.isi | WOS:000582258100001 | - |
dc.contributor.orcid | Zurakowski, Aleksander/0000-0002-5135-6598 | - |
local.provider.type | wosris | - |
local.uhasselt.international | yes | - |
item.fulltext | No Fulltext | - |
item.accessRights | Closed Access | - |
item.fullcitation | Franzone, Anna; McFadden, Eugène P.; Leonardi, Sergio; Piccolo, Raffaele; VRANCKX, Pascal; Serruys, Patrick W.; Hamm, Christian; Steg, Philippe Gabriel; Heg, Dik; Branca, Mattia; Jüni, Peter; Windecker, Stephan & Valgimigli, Marco (2020) Ticagrelor alone or conventional dual antiplatelet therapy in patients with stable or acute coronary syndromes. In: EuroIntervention, 16 (8) , p. 627 -633. | - |
item.contributor | Franzone, Anna | - |
item.contributor | McFadden, Eugène P. | - |
item.contributor | Leonardi, Sergio | - |
item.contributor | Piccolo, Raffaele | - |
item.contributor | VRANCKX, Pascal | - |
item.contributor | Serruys, Patrick W. | - |
item.contributor | Hamm, Christian | - |
item.contributor | Steg, Philippe Gabriel | - |
item.contributor | Heg, Dik | - |
item.contributor | Branca, Mattia | - |
item.contributor | Jüni, Peter | - |
item.contributor | Windecker, Stephan | - |
item.contributor | Valgimigli, Marco | - |
crisitem.journal.issn | 1774-024X | - |
crisitem.journal.eissn | 1969-6213 | - |
Appears in Collections: | Research publications |
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