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http://hdl.handle.net/1942/34527
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DC Field | Value | Language |
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dc.contributor.author | Bossuyt, P. | - |
dc.contributor.author | Baert, F. | - |
dc.contributor.author | COENEGRACHTS, Jean-Louis | - |
dc.contributor.author | De Vos, M. | - |
dc.contributor.author | Dewit, O. | - |
dc.contributor.author | Ferrante, M. | - |
dc.contributor.author | Fontaine, F. | - |
dc.contributor.author | Mana, F. | - |
dc.contributor.author | Vandervoort, J. | - |
dc.contributor.author | Moreels, T. | - |
dc.date.accessioned | 2021-07-24T14:25:49Z | - |
dc.date.available | 2021-07-24T14:25:49Z | - |
dc.date.issued | 2019 | - |
dc.date.submitted | 2021-07-12T13:08:47Z | - |
dc.identifier.citation | ACTA GASTRO-ENTEROLOGICA BELGICA, 82 (3) , p. 365 -372 | - |
dc.identifier.uri | http://hdl.handle.net/1942/34527 | - |
dc.description.abstract | Background : The natural history of ulcerative colitis (UC) is unpredictable. Factors associated with the need for different types of step-up therapy in UC patients failing on 5-aminosalicylic acid (5-ASA) or corticosteroids are understudied. Aims : Describe step-up therapy in patients with UC the first year after failing on 5-ASA or corticosteroids. Methods : A Belgian, multi-center, prospective, non-interventional observational study comprising adult UC patients failing on 5-ASA or corticosteroids and naive to immunomodulators/biologicals. During a 12 months follow-up, patient characteristics, demography, medical therapy, biomarkers, therapy adherence and quality of life (QoL) were assessed. Results : After 1 year, 35% of the patients were on biological therapy. Use of anti-TNF; differed depending on baseline treatment: corticosteroid-refractory patients (55.8%), 5-ASA refractory (20.0%), and corticosteroid-dependent (16.0%) patients (p<0.001). The decision to start a line of therapy was based on the Mayo combined severity but not on biomarkers like faecal calprotectin, haemoglobin, CRP, albumin, platelets, and number of extra-intestinal manifestations. At year 1, 84.2% of the patients had only mild CC or remission and a significant improvement of fatigue (p=0.004) and IBDQ scores (p<0.001) were observed implying an improved QoL. Conclusion : Treatment step-up, based on clinical scores in immunomodulatory and anti-TNF naive patients with UC, provides good clinical outcomes and QoL. | - |
dc.language.iso | en | - |
dc.publisher | - | |
dc.subject.other | step-up therapy | - |
dc.subject.other | immunomodulators | - |
dc.subject.other | anti-TNF | - |
dc.subject.other | clinical scores | - |
dc.title | Ulcerative colitis treatment : an insight into daily clinical practice | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 372 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 365 | - |
dc.identifier.volume | 82 | - |
local.bibliographicCitation.jcat | A1 | - |
local.contributor.corpauthor | Belgian Inflammatory Bowel Disease Research and Development Group (BIRD) | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.class | IncludeIn-ExcludeFrom-List/ExcludeFromFRIS | - |
dc.identifier.isi | WOS:000487985600003 | - |
dc.contributor.orcid | Bossuyt, Peter/0000-0003-4027-7365 | - |
dc.identifier.eissn | - | |
local.provider.type | wosris | - |
item.fulltext | With Fulltext | - |
item.accessRights | Restricted Access | - |
item.contributor | Bossuyt, P. | - |
item.contributor | Baert, F. | - |
item.contributor | COENEGRACHTS, Jean-Louis | - |
item.contributor | De Vos, M. | - |
item.contributor | Dewit, O. | - |
item.contributor | Ferrante, M. | - |
item.contributor | Fontaine, F. | - |
item.contributor | Mana, F. | - |
item.contributor | Vandervoort, J. | - |
item.contributor | Moreels, T. | - |
item.fullcitation | Bossuyt, P.; Baert, F.; COENEGRACHTS, Jean-Louis; De Vos, M.; Dewit, O.; Ferrante, M.; Fontaine, F.; Mana, F.; Vandervoort, J. & Moreels, T. (2019) Ulcerative colitis treatment : an insight into daily clinical practice. In: ACTA GASTRO-ENTEROLOGICA BELGICA, 82 (3) , p. 365 -372. | - |
crisitem.journal.issn | 1784-3227 | - |
crisitem.journal.eissn | 1784-3227 | - |
Appears in Collections: | Research publications |
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03-Bossuyt.pdf Restricted Access | Published version | 688.7 kB | Adobe PDF | View/Open Request a copy |
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