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http://hdl.handle.net/1942/34566
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DC Field | Value | Language |
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dc.contributor.author | Koch, Sarah | - |
dc.contributor.author | Zelembaba, Ana | - |
dc.contributor.author | Tran, Raymond | - |
dc.contributor.author | LAEREMANS, Michelle | - |
dc.contributor.author | Hives, Benjamin | - |
dc.contributor.author | Carlsten, Christopher | - |
dc.contributor.author | DE BOEVER, Patrick | - |
dc.contributor.author | Koehle, Michael Stephen | - |
dc.date.accessioned | 2021-07-26T14:18:40Z | - |
dc.date.available | 2021-07-26T14:18:40Z | - |
dc.date.issued | 2020 | - |
dc.date.submitted | 2021-07-08T14:29:25Z | - |
dc.identifier.citation | Environmental research (New York, N.Y. Print), 183 (Art N° 109270) | - |
dc.identifier.uri | http://hdl.handle.net/1942/34566 | - |
dc.description.abstract | Background: The combined effects of physical activity and air pollution exposure on vascular function are insufficiently understood, particularly after the inhalation of a beta(2)-agonist, a vasodilating agent. Objective: To assess the micro- and macrovascular response to physical activity after beta(2)-agonist use while breathing diesel exhaust (DE) in individuals with exercise-induced bronchoconstriction. Methods: On four exposure visits, eighteen adults inhaled either 400 mu g of the beta(2)-agonist salbutamol or placebo before resting for 60 min, followed by a 30-min cycling bout. During rest and cycling, participants inhaled filtered air (FA) or DE (300 mu g/m(3) of PM2.5). Microvascular (central retinal arteriolar and venular equivalents, CRAE and CRVE, respectively) and macrovascular parameters (blood pressure (BP)) and heart rate (HR)) were assessed at baseline (T-1), 10 min (T-2) and 70 min (T-3) after cycling. Results: The cycling bout increased CRAE (T-2-T-1 difference (95th % confidence interval): 4.88 mu m (4.73, 5.00 mu m), p < 0.001; T-3-T-1 difference: 2.10 mu m (1.62, 2.58 mu m), p = 0.031) and CRVE (T-2-T-1 difference: 3.78 mu m (3.63, 3.92 mu m), p < 0.001; T-3-T-1 difference: 3.73 mu m (3.63, 3.92 mu m), p < 0.001). The exposure to DE had no effect on CRAE (FA-DE difference at T-2: 0.46 mu m (-0.02, 0.92 mu m); p = 0.790; FA-DE difference at T-3: 1.76 mu m (1.36, 2.16 mu m), p = 0.213) and CRVE (FA-DE difference at T-2: 0.26 mu m (-0.35, 0.88 mu m), p = 0.906; FA-DE difference at T-3: 0.55 mu m (0.05, 1.06 mu m), p = 0.750). Compared to T-1, systolic BP was decreased at T-2 by 2.5 mmHg (2.8, 2.3 mmHg, p = 0.047), independent of inhaled exposure. Heart rate at T-2 was significantly increased by 3 bpm (2, 3 bpm, p = 0.025) after the DE-exposure when compared to FA. Discussion: Acute physical activity induces a vasodilatory response in the micro- and macrovasculature in healthy adults by increasing CRAE and CRVE, and by reducing systolic BP post exercise, despite breathing DE. The DE-associated increase in HR might be indicative of an increased sympathetic response to physical activity while breathing DE. | - |
dc.language.iso | en | - |
dc.title | Vascular effects of physical activity are not modified by short-term inhaled diesel exhaust: Results of a controlled human exposure study | - |
dc.type | Journal Contribution | - |
dc.identifier.volume | 183 | - |
local.bibliographicCitation.jcat | A1 | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 109270 | - |
dc.identifier.doi | 10.1016/j.envres.2020.109270 | - |
dc.identifier.isi | WOS:000526177500122 | - |
dc.contributor.orcid | De Boever, Patrick/0000-0002-5197-8215; Koehle, Michael | - |
dc.contributor.orcid | S/0000-0001-7026-8422; Hives, Ben/0000-0001-8874-8678; Laeremans, | - |
dc.contributor.orcid | Michelle/0000-0002-1406-7893; Koch, Sarah/0000-0001-9461-8407 | - |
local.provider.type | wosris | - |
local.uhasselt.international | yes | - |
item.fullcitation | Koch, Sarah; Zelembaba, Ana; Tran, Raymond; LAEREMANS, Michelle; Hives, Benjamin; Carlsten, Christopher; DE BOEVER, Patrick & Koehle, Michael Stephen (2020) Vascular effects of physical activity are not modified by short-term inhaled diesel exhaust: Results of a controlled human exposure study. In: Environmental research (New York, N.Y. Print), 183 (Art N° 109270). | - |
item.contributor | Koch, Sarah | - |
item.contributor | Zelembaba, Ana | - |
item.contributor | Tran, Raymond | - |
item.contributor | LAEREMANS, Michelle | - |
item.contributor | Hives, Benjamin | - |
item.contributor | Carlsten, Christopher | - |
item.contributor | DE BOEVER, Patrick | - |
item.contributor | Koehle, Michael Stephen | - |
item.fulltext | With Fulltext | - |
item.accessRights | Restricted Access | - |
crisitem.journal.issn | 0013-9351 | - |
crisitem.journal.eissn | 1096-0953 | - |
Appears in Collections: | Research publications |
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1-s2.0-S0013935120301638-main.pdf Restricted Access | Published version | 1.33 MB | Adobe PDF | View/Open Request a copy |
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