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Title: | Urinary N-acetyltyramine-O,β-glucuronide in Persons with Onchocerciasis-Associated Epilepsy | Authors: | Hotterbeekx, An Dusabimana, Alfred Mandro, Michel Abhafule, Germain M Deogratias, Wonya’Rossy Siewe Fodjo, Joseph N. ABRAMS, Steven Colebunders, Robert |
Issue Date: | 2020 | Publisher: | MDPI | Source: | Pathogens, 9 (3) (Art N° 191) | Abstract: | We investigated urinary N-acetyltyramine-O,beta-glucuronide (NATOG) levels as a biomarker for active Onchocerca volvulus infection in an onchocerciasis-endemic area in the Democratic Republic of Congo with a high epilepsy prevalence. Urinary NATOG was measured in non-epileptic men with and without O. volvulus infection, and in O. volvulus-infected persons with epilepsy (PWE). Urinary NATOG concentration was positively associated with microfilarial density (p < 0.001). The median urinary NATOG concentration was higher in PWE (3.67 mu M) compared to men without epilepsy (1.74 mu M), p = 0.017; and was higher in persons with severe (7.62 mu M) compared to mild epilepsy (2.16 mu M); p = 0.008. Non-epileptic participants with and without O. volvulus infection had similar NATOG levels (2.23 mu M and 0.71 mu M, p = 0.426). In a receiver operating characteristic curve analysis to investigate the diagnostic value of urinary NATOG, the area under the curve was 0.721 (95% CI: 0.633-0.797). Using the previously proposed cut-off value of 13 mu M to distinguish between an active O. volvulus infection and an uninfected state, the sensitivity was 15.9% and the specificity 95.9%. In conclusion, an O. volvulus infection is associated with an increased urinary NATOG concentration, which correlates with the individual parasitic load. However, the NATOG concentration has a low discriminating power to differentiate between infected and uninfected individuals. | Keywords: | Onchocerca volvulus;N-acetyltyramine-O,β-glucuronide (NATOG), epilepsy;Africa;biomarker;urine | Document URI: | http://hdl.handle.net/1942/34573 | e-ISSN: | 2076-0817 | DOI: | 10.3390/pathogens9030191 | ISI #: | WOS:000524306100018 | Rights: | 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2021 |
Appears in Collections: | Research publications |
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pathogens-09-00191-v2.pdf | Published version | 668.32 kB | Adobe PDF | View/Open |
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