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Title: | The impact of pre-procedure heart rate on adverse clinical outcomes in patients undergoing percutaneous coronary intervention: Results from a 2-year follow-up of the GLOBAL LEADERS trial | Authors: | Wang, Rutao Takahashi, Kuniaki Chichareon, Ply Gao, Chao Kogame, Norihiro Modolo, Rodrigo Tomaniak, Mariusz Kawashima, Hideyuki Ono, Masafumi Hara, Hironori Schächinger, Volker Tonev, Gincho Ungi, Imre Botelho, Roberto Eeckhout, Eric Hamm, Christian Jüni, Peter VRANCKX, Pascal Windecker, Stephan Garg, Scot Van Geuns, Robert Jan Onuma, Yoshinobu Serruys, Patrick W. |
Issue Date: | 2020 | Publisher: | ELSEVIER IRELAND LTD | Source: | Atherosclerosis (Amsterdam), 303 , p. 1 -7 | Abstract: | Background and aims: The prognostic impact of pre-procedure heart rate (PHR) following percutaneous coronary intervention (PCI) has not yet been fully investigated. This post-hoc analysis sought to assess the impact of PHR on medium-term outcomes among patients having PCI, who were enrolled in the "all-comers" GLOBAL LEADERS trial. Methods and results: The primary endpoint (composite of all-cause death or new Q-wave myocardial infarction [MI]) and key secondary safety endpoint (bleeding according to Bleeding Academic Research Consortium [BARC] type 3 or 5) were assessed at 2 years. PHR was available in 15,855 patients, and when evaluated as a continuous variable (5 bpm increase) and following adjustment using multivariate Cox regression, it significantly correlated with the primary endpoint (hazard ratio [HR] 1.06, 95% confidence interval [CI] 1.03-1.09, p < 0.001). Using dichotomous cut-off criteria, a PHR> 67 bpm was associated with increased allcause mortality (HR 1.38, 95%CI 1.13-1.69, p = 0.002) and more frequent new Q-wave MI (HR 1.41, 95%CI 1.02-1.93, p = 0.037). No significant association was found between PHR and BARC 3 or 5 bleeding (HR 1.04, 95% | Keywords: | Coronary artery disease;Percutaneous coronary intervention;Pre-procedure heart rate;Mortality;Predictor | Document URI: | http://hdl.handle.net/1942/34593 | ISSN: | 0021-9150 | e-ISSN: | 1879-1484 | DOI: | 10.1016/j.atherosclerosis.2020.04.010 | ISI #: | WOS:000545027000001 | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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1-s2.0-S0021915020302094-main.pdf | Published version | 533.93 kB | Adobe PDF | View/Open |
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