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http://hdl.handle.net/1942/34617
Title: | Impact of COVID-19 Pandemic on Mechanical Reperfusion for Patients With STEMI | Authors: | De Luca, Giuseppe Verdoia, Monica Cercek, Miha Jensen, Lisette Okkels Vavlukis, Marija Calmac, Lucian Johnson, Tom Ferrer, Gerard Rourai Ganyukov, Vladimir Wojakowski, Wojtek Kinnaird, Tim van Birgelen, Clemens Cottin, Yves IJsselmuiden, Alexander Tuccillo, Bernardo Versaci, Francesco Royaards, Kees-Jan Berg, Jurrien Ten Laine, Mika Dirksen, Maurits Siviglia, Massimo Casella, Gianni Kala, Petr Díez Gil, José Luis Banning, Adrian Becerra, Victor De Simone, Ciro Santucci, Andrea Carrillo, Xavier Scoccia, Alessandra Amoroso, Giovanni Lux, Arpad Kovarnik, Tomas Davlouros, Periklis Mehilli, Julinda Gabrielli, Gabriele Rios, Xacobe Flores Bakraceski, Nikola Levesque, Sébastien Cirrincione, Giuseppe Guiducci, Vincenzo Kidawa, Michał Spedicato, Leonardo Marinucci, Lucia Ludman, Peter Zilio, Filippo Galasso, Gennaro Fabris, Enrico Menichelli, Maurizio Garcia-Touchard, Arturo Manzo, Stephane Caiazzo, Gianluca Moreu, Jose Forés, Juan Sanchis Donazzan, Luca Vignali, Luigi Teles, Rui BENIT, Edouard Agostoni, Pierfrancesco Bosa Ojeda, Francisco Lehtola, Heidi Camacho-Freiere, Santiago Kraaijeveld, Adriaan Antti, Ylitalo Boccalatte, Marco Deharo, Pierre Martínez-Luengas, Iñigo Lozano Scheller, Bruno Alexopoulos, Dimitrios Moreno, Raul Kedhi, Elvin Uccello, Giuseppe Faurie, Benjamin Gutierrez Barrios, Alejandro Di Uccio, Fortunato Scotto Wilbert, Bor Smits, Pieter Cortese, Giuliana Parodi, Guido Dudek, Dariusz |
Issue Date: | 2020 | Publisher: | ELSEVIER SCIENCE INC | Source: | Journal of the American College of Cardiology (Print), 76 (20) , p. 2321 -2330 | Abstract: | BACKGROUND The fear of contagion during the coronavirus disease-2019 (COVID-19) pandemic may have potentially refrained patients with ST-segment elevation myocardial infarction (STEMI) from accessing the emergency system, with subsequent impact on mortality. OBJECTIVES The ISACS-STEMI COVID-19 registry aims to estimate the true impact of the COVID-19 pandemic on the treatment and outcome of patients with STEMI treated by primary percutaneous coronary intervention (PPCI), with identification of "at-risk" patient cohorts for failure to present or delays to treatment. METHODS This retrospective registry was performed in European high-volume PPCI centers and assessed patients with STEMI treated with PPPCI in March/April 2019 and 2020. Main outcomes are the incidences of PPCI, delayed treatment, and in-hospital mortality. RESULTS A total of 6,609 patients underwent PPCI in 77 centers, located in 18 countries. In 2020, during the pandemic, there was a significant reduction in PPCI as compared with 2019 (incidence rate ratio: 0.811; 95% confidence interval: 0.78 to 0.84; p < 0.0001). The heterogeneity among centers was not related to the incidence of death due to COVID-19. A significant interaction was observed for patients with arterial hypertension, who were less frequently admitted in 2020 than in 2019. Furthermore, the pandemic was associated with a significant increase in door-to-balloon and total ischemia times, which may have contributed to the higher mortality during the pandemic. CONCLUSIONS The COVID-19 pandemic had significant impact on the treatment of patients with STEMI, with a 19% reduction in PPCI procedures, especially among patients suffering from hypertension, and a longer delay to treatment, which may have contributed to the increased mortality during the pandemic. (C) 2020 by the American College of Cardiology Foundation. | Keywords: | COVID-19;primary angioplasty;STEMI | Document URI: | http://hdl.handle.net/1942/34617 | ISSN: | 0735-1097 | e-ISSN: | 1558-3597 | DOI: | 10.1016/j.jacc.2020.09.546 | ISI #: | WOS:000600579800005 | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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