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http://hdl.handle.net/1942/34619
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DC Field | Value | Language |
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dc.contributor.author | Van Loon, Elisabet | - |
dc.contributor.author | Giral, Magali | - |
dc.contributor.author | Anglicheau, Dany | - |
dc.contributor.author | Lerut, Evelyne | - |
dc.contributor.author | Dubois, Valérie | - |
dc.contributor.author | Rabeyrin, Maud | - |
dc.contributor.author | Brouard, Sophie | - |
dc.contributor.author | Roedder, Silke | - |
dc.contributor.author | Spigarelli, Michael G. | - |
dc.contributor.author | Rabant, Marion | - |
dc.contributor.author | BOGAERTS, Kris | - |
dc.contributor.author | Naesens, Maarten | - |
dc.contributor.author | Thaunat, Olivier | - |
dc.date.accessioned | 2021-08-05T15:57:12Z | - |
dc.date.available | 2021-08-05T15:57:12Z | - |
dc.date.issued | 2021 | - |
dc.date.submitted | 2021-07-08T12:55:48Z | - |
dc.identifier.citation | American journal of transplantation, 21 (2) , p. 740 -750 | - |
dc.identifier.issn | 16006135 | - |
dc.identifier.uri | http://hdl.handle.net/1942/34619 | - |
dc.description.abstract | The Kidney Solid Organ Response Test (kSORT) blood gene expression assay was developed to noninvasively detect acute rejection (AR) after kidney transplantation. Its performance in a setting with natural disease prevalence has not been evaluated. A retrospective, multicenter cohort study was conducted across all single kidney transplant recipients, transplanted between 2011 and 2015, with samples within the first year after transplantation available in existing biobanks. The primary objective was to determine the diagnostic performance of the kSORT assay to detect AR (T cell-mediated and/or antibody-mediated rejection) as compared to a concomitant renal biopsy. AR was reported on the concomitant biopsy in 188 of 1763 (10.7%) blood samples and any rejection (including borderline changes) in 614 of 1763 (34.8%) blood samples. In 320 of 1763 samples (18.2%) the kSORT risk category was indeterminate. The kSORT assay had no diagnostic value for AR (area under the curve [AUC] 0.51, 95% confidence interval [CI] 0.50-0.56;P = .46) overall, or when considering indication biopsies (N = 487) and protocol-specified biopsies (N = 1276) separately (AUC of 0.53, 95% CI 0.50-0.59,P = .44 and 0.55, 95% CI 0.50-0.61,P = .09, respectively). This large retrospective study utilizing samples obtained under real-world clinical conditions, was unable to validate the kSORT assay for detection of AR in the first year after transplantation. | - |
dc.description.sponsorship | EVL holds a fellowship grant (1143919N) from The Research Foundation Flanders. We thank the four clinical centers, the clinicians and surgeons, nursing staff, and the patients. The CENTAURE research network (https://www.fondation-centaure.org) would like to thank the biological resource center for biobanking of Nantes Hotel-Dieu University hospital (CRB Nantes, F-44093, France - BRIF : BB0033-00040) for their help in the preparation of the samples. The authors would like to thank the members of the DIVAT consortium for their involvement in the study, the physicians who helped recruit patients, and all patients who participated in this study. We also thank the clinical research associates who participated in the data collection. (DIVAT = Données Informatisées et VAlidées en Transplantation, DIVAT Cohort Collaborators (Medical Doctors, Surgeons, HLA Biologists) with for: Nantes: Gilles Blancho, Julien Branchereau, Diego Cantarovich, Agnès Chapelet, Jacques Dantal, Clément Deltombe, Lucile Figueres, Claire Garandeau, Caroline Gourraud-Vercel, Maryvonne Hourmant, Georges Karam, Clarisse Kerleau, Aurélie Meurette, Simon Ville, Christine Kandell, Anne Moreau, Karine Renaudin, Anne Cesbron, Florent Delbos, Alexandre Walencik, Anne Devis; Paris-Necker : Lucile Amrouche, Olivier Aubert, Lynda Bererhi, Christophe Legendre, Alexandre Loupy, Frank Martinez, Rébecca Sberro-Soussan, Anne Scemla, Claire Tinel, Julien Zuber; Lyon E. Hériot : Lionel Badet, Maria Brunet, Fanny Buron, Rémi Cahen, Sameh Daoud, Coralie Fournie, Arnaud Grégoire, Alice Koenig, Charlène Lévi, Emmanuel Morelon, Claire Pouteil-Noble, Thomas Rimmelé). | - |
dc.language.iso | en | - |
dc.rights | 2020 The American Society of Transplantation and the American Society of Transplant Surgeons | - |
dc.subject.other | Maarten Naesens and Olivier Thaunat are equally contributed + For the DIVAT consortium Abbreviations: ABMR, antibody-mediated rejection | - |
dc.subject.other | AR, acute rejection | - |
dc.subject.other | AUC, area under the curve | - |
dc.subject.other | BL-TCMR, borderline changes | - |
dc.subject.other | BX, biopsy | - |
dc.subject.other | CI, confidence interval | - |
dc.subject.other | DSA, donor-specific anti-HLA antibodies | - |
dc.subject.other | eGFR, estimated GFR | - |
dc.subject.other | HR, high risk for rejection | - |
dc.subject.other | IND, indeterminate result | - |
dc.subject.other | IQR, interquartile range | - |
dc.subject.other | kSORT, Kidney Solid Organ Response Test | - |
dc.subject.other | LR, low risk for rejection | - |
dc.subject.other | NPV, negative predictive value | - |
dc.subject.other | PPV, positive predictive value | - |
dc.subject.other | ROC, receiver-operating characteristic | - |
dc.subject.other | sABMR, suspicious for antibody-mediated rejection | - |
dc.subject.other | TCMR, T cell-mediated rejection | - |
dc.title | Diagnostic performance of kSORT, a blood-based mRNA assay for noninvasive detection of rejection after kidney transplantation: A retrospective multicenter cohort study | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 750 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 740 | - |
dc.identifier.volume | 21 | - |
local.bibliographicCitation.jcat | A1 | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1111/ajt.16179 | - |
dc.identifier.pmid | 32627407 | - |
dc.identifier.isi | WOS:000555271700001 | - |
dc.contributor.orcid | Van Loon, Elisabet/0000-0001-9796-9157; Brouard, | - |
dc.contributor.orcid | Sophie/0000-0002-6398-1315; Bogaerts, Kris/0000-0003-0188-8665 | - |
dc.identifier.eissn | 1600-6143 | - |
local.provider.type | wosris | - |
local.uhasselt.international | yes | - |
item.validation | ecoom 2021 | - |
item.contributor | Van Loon, Elisabet | - |
item.contributor | Giral, Magali | - |
item.contributor | Anglicheau, Dany | - |
item.contributor | Lerut, Evelyne | - |
item.contributor | Dubois, Valérie | - |
item.contributor | Rabeyrin, Maud | - |
item.contributor | Brouard, Sophie | - |
item.contributor | Roedder, Silke | - |
item.contributor | Spigarelli, Michael G. | - |
item.contributor | Rabant, Marion | - |
item.contributor | BOGAERTS, Kris | - |
item.contributor | Naesens, Maarten | - |
item.contributor | Thaunat, Olivier | - |
item.accessRights | Open Access | - |
item.fullcitation | Van Loon, Elisabet; Giral, Magali; Anglicheau, Dany; Lerut, Evelyne; Dubois, Valérie; Rabeyrin, Maud; Brouard, Sophie; Roedder, Silke; Spigarelli, Michael G.; Rabant, Marion; BOGAERTS, Kris; Naesens, Maarten & Thaunat, Olivier (2021) Diagnostic performance of kSORT, a blood-based mRNA assay for noninvasive detection of rejection after kidney transplantation: A retrospective multicenter cohort study. In: American journal of transplantation, 21 (2) , p. 740 -750. | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 1600-6135 | - |
crisitem.journal.eissn | 1600-6143 | - |
Appears in Collections: | Research publications |
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ajt.16179.pdf Restricted Access | Published version | 791.52 kB | Adobe PDF | View/Open Request a copy |
ajt.16179 (1).pdf | Peer-reviewed author version | 11.83 MB | Adobe PDF | View/Open |
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