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http://hdl.handle.net/1942/34649
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DC Field | Value | Language |
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dc.contributor.author | Ploumen, Eline H. | - |
dc.contributor.author | Buiten, Rosaly A. | - |
dc.contributor.author | Doggen, Carine J.M. | - |
dc.contributor.author | Stoel, Martin G. | - |
dc.contributor.author | van Houwelingen, K. Gert | - |
dc.contributor.author | Schotborgh, Carl E. | - |
dc.contributor.author | Jessurun, Gillian A.J. | - |
dc.contributor.author | Roguin, Ariel | - |
dc.contributor.author | Danse, Peter W. | - |
dc.contributor.author | BENIT, Edouard | - |
dc.contributor.author | Aminian, Adel | - |
dc.contributor.author | Linssen, Gerard C.M. | - |
dc.contributor.author | de Man, Frits H.A.F. | - |
dc.contributor.author | Hartmann, Marc | - |
dc.contributor.author | Buiten, Diedrik G. | - |
dc.contributor.author | Kok, Marlies M. | - |
dc.contributor.author | Zocca, Paolo | - |
dc.contributor.author | von Birgelen, Clemens | - |
dc.date.accessioned | 2021-08-06T13:50:32Z | - |
dc.date.available | 2021-08-06T13:50:32Z | - |
dc.date.issued | 2020 | - |
dc.date.submitted | 2021-07-08T09:14:14Z | - |
dc.identifier.citation | The American heart journal, 228 , p. 109 -115 | - |
dc.identifier.uri | http://hdl.handle.net/1942/34649 | - |
dc.description.abstract | Background Patients aged >= 80 years are often treated with new-generation drug-eluting stents (DES), but data from randomized studies are scarce owing to underrepresentation in most trials. We assessed 1-year clinical outcome of octogenarians treated with new-generation DES versus younger patients. Methods We pooled patient-level data of 9,204 participants in the TWENTE, DUTCH PEERS, BIO-RESORT, and BIONYX (TWENTE I-IV) randomized trials. The main clinical end point was target vessel failure (TVF), a composite of cardiac death, target vessel-related myocardial infarction (MI), or clinically indicated target vessel revascularization. Results The 671 octogenarian trial participants had significantly more comorbidities. TVF was higher in octogenarians than in 8,533 patients <80 years (7.3% vs 5.3%, hazard ratio [HR]: 1.36, 95% CI: 1.0-1.83, P = .04). The cardiac death rate was higher in octogenarians (3.9% vs 0.8%, P < .001). There was no significant between-group difference in target vessel MI (2.3% vs 2.3%, P = .88) and repeat target vessel revascularization (1.9% vs 2.8%, P = .16). In multivariate analyses, age 80 years showed no independent association with TVF (adjusted HR: 1.04, 95% CI: 0.76-1.42), whereas the risk of cardiac death remained higher in octogenarians (adjusted HR: 3.38, 95% CI: 2.07-5.52, P < .001). In 6,002 trial participants, in whom data on major bleeding were recorded, octogenarians (n = 459) showed a higher major bleeding risk (5.9% vs 1.9%; HR: 3.08, 95% CI: 2.01-4.74, P < .001). Conclusions Octogenarian participants in 4 large-scale randomized DES trials had more comorbidities and a higher incidence of the main end point TVF. Cardiac mortality was higher in octogenarians, whereas there was no increase in MI or target vessel revascularization rates. Treatment of octogenarian patients with new-generation DES appears to be safe and effective. | - |
dc.language.iso | en | - |
dc.publisher | - | |
dc.title | New-generation drug-eluting coronary stents in octogenarians: Patient-level pooled analysis from the TWENTE I-IV trials | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 115 | - |
dc.identifier.spage | 109 | - |
dc.identifier.volume | 228 | - |
local.bibliographicCitation.jcat | A1 | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.class | IncludeIn-ExcludeFrom-List/ExcludeFromFRIS | - |
dc.identifier.doi | 10.1016/j.ahj.2020.07.003 | - |
dc.identifier.isi | WOS:000572689300015 | - |
dc.contributor.orcid | Ploumen, Eline/0000-0002-2689-3180 | - |
local.provider.type | wosris | - |
local.uhasselt.international | yes | - |
item.contributor | Ploumen, Eline H. | - |
item.contributor | Buiten, Rosaly A. | - |
item.contributor | Doggen, Carine J.M. | - |
item.contributor | Stoel, Martin G. | - |
item.contributor | van Houwelingen, K. Gert | - |
item.contributor | Schotborgh, Carl E. | - |
item.contributor | Jessurun, Gillian A.J. | - |
item.contributor | Roguin, Ariel | - |
item.contributor | Danse, Peter W. | - |
item.contributor | BENIT, Edouard | - |
item.contributor | Aminian, Adel | - |
item.contributor | Linssen, Gerard C.M. | - |
item.contributor | de Man, Frits H.A.F. | - |
item.contributor | Hartmann, Marc | - |
item.contributor | Buiten, Diedrik G. | - |
item.contributor | Kok, Marlies M. | - |
item.contributor | Zocca, Paolo | - |
item.contributor | von Birgelen, Clemens | - |
item.fulltext | With Fulltext | - |
item.fullcitation | Ploumen, Eline H.; Buiten, Rosaly A.; Doggen, Carine J.M.; Stoel, Martin G.; van Houwelingen, K. Gert; Schotborgh, Carl E.; Jessurun, Gillian A.J.; Roguin, Ariel; Danse, Peter W.; BENIT, Edouard; Aminian, Adel; Linssen, Gerard C.M.; de Man, Frits H.A.F.; Hartmann, Marc; Buiten, Diedrik G.; Kok, Marlies M.; Zocca, Paolo & von Birgelen, Clemens (2020) New-generation drug-eluting coronary stents in octogenarians: Patient-level pooled analysis from the TWENTE I-IV trials. In: The American heart journal, 228 , p. 109 -115. | - |
item.accessRights | Open Access | - |
crisitem.journal.issn | 0002-8703 | - |
crisitem.journal.eissn | 1097-6744 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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1-s2.0-S000287032030209X-main.pdf | Published version | 608.83 kB | Adobe PDF | View/Open |
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