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http://hdl.handle.net/1942/34707
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DC Field | Value | Language |
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dc.contributor.author | Fokas, Emmanouil | - |
dc.contributor.author | Appelt, Ane | - |
dc.contributor.author | Glynne-Jones, Robert | - |
dc.contributor.author | Beets, Geerard | - |
dc.contributor.author | Perez, Rodrigo | - |
dc.contributor.author | Garcia-Aguilar, Julio | - |
dc.contributor.author | Rullier, Eric | - |
dc.contributor.author | Joshua Smith, J. | - |
dc.contributor.author | Marijnen, Corrie | - |
dc.contributor.author | Peters, Femke P. | - |
dc.contributor.author | van der Valk, Maxine | - |
dc.contributor.author | Beets-Tan, Regina | - |
dc.contributor.author | Myint, Arthur S. | - |
dc.contributor.author | Gerard, Jean-Pierre | - |
dc.contributor.author | Bach, Simon P. | - |
dc.contributor.author | Ghadimi, Michael | - |
dc.contributor.author | Hofheinz, Ralf D. | - |
dc.contributor.author | Bujko, Krzysztof | - |
dc.contributor.author | Haustermans, Karin | - |
dc.contributor.author | Minsky, Bruce D. | - |
dc.contributor.author | Ludmir, Ethan | - |
dc.contributor.author | West, Nicholas P. | - |
dc.contributor.author | Gambacorta, Maria A. | - |
dc.contributor.author | Valentini, Vincenzo | - |
dc.contributor.author | BUYSE, Marc | - |
dc.contributor.author | Renehan, Andrew G. | - |
dc.contributor.author | Gilbert, Alexandra | - |
dc.contributor.author | Sebag-Montefiore, David | - |
dc.contributor.author | Roedel, Claus | - |
dc.contributor.author | Gani, Cihan | - |
dc.date.accessioned | 2021-08-22T18:35:18Z | - |
dc.date.available | 2021-08-22T18:35:18Z | - |
dc.date.issued | 2021 | - |
dc.date.submitted | 2021-08-22T17:53:35Z | - |
dc.identifier.citation | Nature Reviews Clinical Oncology, 18, p. 805-816 | - |
dc.identifier.uri | http://hdl.handle.net/1942/34707 | - |
dc.description.abstract | Multimodal treatment strategies for patients with rectal cancer are increasingly including the possibility of organ preservation, through nonoperative management or local excision. Organ preservation strategies can enable patients with a complete response or near-complete clinical responses after radiotherapy with or without concomitant chemotherapy to safely avoid the morbidities associated with radical surgery, and thus to maintain anorectal function and quality of life. However, standardization of the key outcome measures of organ preservation strategies is currently lacking; this includes a lack of consensus of the optimal definitions and selection of primary end points according to the trial phase and design; the optimal time points for response assessment; response-based decision-making; follow-up schedules; use of specific anorectal function tests; and quality of life and patient-reported outcomes. Thus, a consensus statement on outcome measures is necessary to ensure consistency and facilitate more accurate comparisons of data from ongoing and future trials. Here, we have convened an international group of experts with extensive experience in the management of patients with rectal cancer, including organ preservation approaches, and used a Delphi process to establish the first international consensus recommendations for key outcome measures of organ preservation, in an attempt to standardize the reporting of data from both trials and routine practice in this emerging area. Patients with early-stage rectal cancer might potentially benefit from treatment with an organ-sparing approach, which preserves quality of life owing to avoidance of the need for permanent colostomy. Trials conducted to investigate this have so far been hampered by considerable inter-trial heterogeneity in several key features. In this Consensus Statement, the authors provide guidance on the optimal end points, response assessment time points, follow-up procedures and quality of life measures in an attempt to improve the comparability of clinical research in this area. | - |
dc.description.sponsorship | The work of A.A. is supported by Yorkshire Cancer Research Academic Fellowship funding (grant L389AA). The work of N.P.W. was supported by grants from Yorkshire Cancer Research while the study was conducted. The work of A.G. is funded by a Cancer Research UK clinical trials fellowship (CRUK/28301). | - |
dc.language.iso | en | - |
dc.publisher | NATURE PORTFOLIO | - |
dc.rights | Springer Nature Limited 2021 | - |
dc.title | International consensus recommendations on key outcome measures for organ preservation after (chemo)radiotherapy in patients with rectal cancer | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 816 | - |
dc.identifier.spage | 805 | - |
dc.identifier.volume | 18 | - |
local.format.pages | 12 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Fokas, E (corresponding author), Goethe Univ Frankfurt, Dept Radiotherapy Oncol, Frankfurt, Germany.; Fokas, E (corresponding author), German Canc Res Ctr, Heidelberg, Germany.; Fokas, E (corresponding author), German Canc Consortium DKTK, Frankfurt, Germany.; Fokas, E (corresponding author), Frankfurt Canc Inst FCI, Frankfurt, Germany. | - |
dc.description.notes | emmanouil.fokas@kgu.de | - |
local.publisher.place | HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1038/s41571-021-00538-5 | - |
dc.identifier.isi | 000681157100001 | - |
dc.contributor.orcid | Glynne-Jones, Rob/0000-0002-6742-222X | - |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
local.description.affiliation | [Fokas, Emmanouil; Roedel, Claus] Goethe Univ Frankfurt, Dept Radiotherapy Oncol, Frankfurt, Germany. | - |
local.description.affiliation | [Fokas, Emmanouil; Roedel, Claus] German Canc Res Ctr, Heidelberg, Germany. | - |
local.description.affiliation | [Fokas, Emmanouil; Roedel, Claus] German Canc Consortium DKTK, Frankfurt, Germany. | - |
local.description.affiliation | [Fokas, Emmanouil; Roedel, Claus] Frankfurt Canc Inst FCI, Frankfurt, Germany. | - |
local.description.affiliation | [Appelt, Ane; Gilbert, Alexandra; Sebag-Montefiore, David] Univ Leeds, Leeds Inst Med Res St Jamess, Leeds, W Yorkshire, England. | - |
local.description.affiliation | [Glynne-Jones, Robert] Mt Vernon Ctr Canc Treatment, Dept Radiotherapy, Northwood, Middx, England. | - |
local.description.affiliation | [Beets, Geerard; Beets-Tan, Regina] Maastricht Univ, GROW Sch Oncol & Dev Biol, Maastricht, Netherlands. | - |
local.description.affiliation | [Beets, Geerard; van der Valk, Maxine] Netherlands Canc Inst Amsterdam, Dept Surg, Amsterdam, Netherlands. | - |
local.description.affiliation | [Perez, Rodrigo] Angelita & Joaquim Inst, Dept Surg, Sao Paulo, Brazil. | - |
local.description.affiliation | [Garcia-Aguilar, Julio; Joshua Smith, J.] Mem Sloan Kettering Canc Ctr, Dept Surg, Colorectal Serv, New York, NY USA. | - |
local.description.affiliation | [Rullier, Eric] CHU Bordeaux, Ctr Hosp Univ, Dept Colorectal Surg, Haut Leveque Hosp, Bordeaux, France. | - |
local.description.affiliation | [Marijnen, Corrie; Peters, Femke P.] Netherlands Canc Inst, Dept Radiat Oncol, Amsterdam, Netherlands. | - |
local.description.affiliation | [Beets-Tan, Regina] Netherlands Canc Inst, Dept Radiol, Amsterdam, Netherlands. | - |
local.description.affiliation | [Myint, Arthur S.] Royal Liverpool Univ Hosp, Clatterbridge Canc Ctr, Liverpool, Merseyside, England. | - |
local.description.affiliation | [Gerard, Jean-Pierre] Ctr Antoine Lacassagne, Serv Radiotherapie, Nice, France. | - |
local.description.affiliation | [Bach, Simon P.] Univ Birmingham, Acad Dept Surg, Birmingham, W Midlands, England. | - |
local.description.affiliation | [Ghadimi, Michael] Univ Med Ctr, Dept Gen Visceral & Paediat Surg, Gottingen, Germany. | - |
local.description.affiliation | [Hofheinz, Ralf D.] Heidelberg Univ, Univ Hosp Mannheim, Dept Med Oncol, Heidelberg, Germany. | - |
local.description.affiliation | [Bujko, Krzysztof] Maria Sklodowska Curie Natl Res Inst Oncol, Dept Radiotherapy, Warsaw, Poland. | - |
local.description.affiliation | [Gani, Cihan] Eberhard Karls Univ Tubingen, Univ Hosp, Dept Radiat Oncol, Tubingen, Germany. | - |
local.description.affiliation | [Gani, Cihan] Eberhard Karls Univ Tubingen, Med Fac Tubingen, Tubingen, Germany. | - |
local.description.affiliation | [Gani, Cihan] German Canc Res Ctr DKFZ Heidelberg, Tubingen, Germany. | - |
local.description.affiliation | [Gani, Cihan] German Consortium Translat Canc Res DKTK Partner, Tubingen, Germany. | - |
local.description.affiliation | [Haustermans, Karin] Univ Hosp Leuven, Dept Radiat Oncol, Leuven, Belgium. | - |
local.description.affiliation | [Minsky, Bruce D.; Ludmir, Ethan] Univ Texas MD Anderson Canc Ctr, Dept Radiat Oncol, Houston, TX USA. | - |
local.description.affiliation | [West, Nicholas P.] Univ Leeds, Sch Med, Leeds Inst Med Res St Jamess, Div Pathol & Data Analyt, Leeds, W Yorkshire, England. | - |
local.description.affiliation | [Gambacorta, Maria A.; Valentini, Vincenzo] Univ Cattolica Sacro Cuore, Fdn Policlin Univ A Gemelli, IRCCS, Dept Radiat Oncol & Med Oncol, Rome, Italy. | - |
local.description.affiliation | [Buyse, Marc] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, Diepenbeek, Belgium. | - |
local.description.affiliation | [Buyse, Marc] Int Drug Dev Inst, San Francisco, CA USA. | - |
local.description.affiliation | [Renehan, Andrew G.] Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Biol Med & Hlth, Sch Med Sci,Div Canc Sci, Manchester, Lancs, England. | - |
local.description.affiliation | [Renehan, Andrew G.] Colorectal & Peritoneal Oncol Ctr, Christie NHS Fdn Trust, Manchester, Lancs, England. | - |
local.uhasselt.international | yes | - |
item.validation | ecoom 2022 | - |
item.fulltext | With Fulltext | - |
item.accessRights | Restricted Access | - |
item.fullcitation | Fokas, Emmanouil; Appelt, Ane; Glynne-Jones, Robert; Beets, Geerard; Perez, Rodrigo; Garcia-Aguilar, Julio; Rullier, Eric; Joshua Smith, J.; Marijnen, Corrie; Peters, Femke P.; van der Valk, Maxine; Beets-Tan, Regina; Myint, Arthur S.; Gerard, Jean-Pierre; Bach, Simon P.; Ghadimi, Michael; Hofheinz, Ralf D.; Bujko, Krzysztof; Haustermans, Karin; Minsky, Bruce D.; Ludmir, Ethan; West, Nicholas P.; Gambacorta, Maria A.; Valentini, Vincenzo; BUYSE, Marc; Renehan, Andrew G.; Gilbert, Alexandra; Sebag-Montefiore, David; Roedel, Claus & Gani, Cihan (2021) International consensus recommendations on key outcome measures for organ preservation after (chemo)radiotherapy in patients with rectal cancer. In: Nature Reviews Clinical Oncology, 18, p. 805-816. | - |
item.contributor | Fokas, Emmanouil | - |
item.contributor | Appelt, Ane | - |
item.contributor | Glynne-Jones, Robert | - |
item.contributor | Beets, Geerard | - |
item.contributor | Perez, Rodrigo | - |
item.contributor | Garcia-Aguilar, Julio | - |
item.contributor | Rullier, Eric | - |
item.contributor | Joshua Smith, J. | - |
item.contributor | Marijnen, Corrie | - |
item.contributor | Peters, Femke P. | - |
item.contributor | van der Valk, Maxine | - |
item.contributor | Beets-Tan, Regina | - |
item.contributor | Myint, Arthur S. | - |
item.contributor | Gerard, Jean-Pierre | - |
item.contributor | Bach, Simon P. | - |
item.contributor | Ghadimi, Michael | - |
item.contributor | Hofheinz, Ralf D. | - |
item.contributor | Bujko, Krzysztof | - |
item.contributor | Haustermans, Karin | - |
item.contributor | Minsky, Bruce D. | - |
item.contributor | Ludmir, Ethan | - |
item.contributor | West, Nicholas P. | - |
item.contributor | Gambacorta, Maria A. | - |
item.contributor | Valentini, Vincenzo | - |
item.contributor | BUYSE, Marc | - |
item.contributor | Renehan, Andrew G. | - |
item.contributor | Gilbert, Alexandra | - |
item.contributor | Sebag-Montefiore, David | - |
item.contributor | Roedel, Claus | - |
item.contributor | Gani, Cihan | - |
crisitem.journal.issn | 1759-4774 | - |
crisitem.journal.eissn | 1759-4782 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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s41571-021-00538-5.pdf Restricted Access | Published version | 1.17 MB | Adobe PDF | View/Open Request a copy |
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