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http://hdl.handle.net/1942/34713
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DC Field | Value | Language |
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dc.contributor.author | EGBERTS, Ginger | - |
dc.contributor.author | VERMOLEN, Fred | - |
dc.contributor.author | van Zuijlen, Paul | - |
dc.date.accessioned | 2021-08-24T19:04:00Z | - |
dc.date.available | 2021-08-24T19:04:00Z | - |
dc.date.issued | 2021 | - |
dc.date.submitted | 2021-08-23T13:43:46Z | - |
dc.identifier.citation | Biomechanics and modeling in mechanobiology (Print), 20(6), p. 2147-2167 | - |
dc.identifier.issn | 1617-7959 | - |
dc.identifier.uri | http://hdl.handle.net/1942/34713 | - |
dc.description.abstract | We consider a one-dimensional morphoelastic model describing post-burn scar contraction. Contraction can lead to a limited range of motion (contracture). Reported prevalence of burn scar contractures are 58.6% at 3-6 weeks and 20.9% at 12 months post-reconstructive surgery after burns. This model describes the displacement of the dermal layer of the skin and the development of the effective Eulerian strain in the tissue. Besides these components, the model also contains components that play a major role in the skin repair after trauma. These components are signaling molecules, fibroblasts, myofibroblasts, and collagen. We perform a sensitivity analysis for many parameters of the model and use the results for a feasibility study. In this study, we test whether the model is suitable for predicting the extent of contraction in different age groups. To this end, we conduct an extensive literature review to find parameter values. From the sensitivity analysis, we conclude that the most sensitive parameters are the equilibrium collagen concentration in the dermal layer, the apoptosis rate of fibroblasts and myofibroblasts, and the secretion rate of signaling molecules. Further, although we can use the model to simulate significant distinct contraction densities in different age groups, our results differ from what is seen in the clinic. This particularly concerns children and elderly patients. In children we see more intense contractures if the burn injury occurs near a joint, because the growth induces extra forces on the tissue. Elderly patients seem to suffer less from contractures, possibly because of excess skin. | - |
dc.description.sponsorship | The authors are grateful for the fnancial support by the Dutch Burns Foundation under Project 17.105. This project is funded by the Dutch Burns Foundation under Project 17.105. | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER HEIDELBERG | - |
dc.rights | The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. | - |
dc.subject.other | Burns | - |
dc.subject.other | Wound contraction | - |
dc.subject.other | Sensitivity | - |
dc.subject.other | Feasibility | - |
dc.subject.other | Morphoelasticity | - |
dc.subject.other | Moving-grid fnite-element | - |
dc.title | Sensitivity and feasibility of a one-dimensional morphoelastic model for post-burn contraction | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 2167 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 2147 | - |
dc.identifier.volume | 20 | - |
local.format.pages | 21 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Egberts, G (corresponding author), Delft Univ Technol, Delft Inst Appl Math, Delft, Netherlands.; Egberts, G (corresponding author), Univ Hasselt, Dept Math & Stat, Res Grp Computat Math CMAT, Hasselt, Belgium. | - |
dc.description.notes | G.Egberts@tudelft.nl; fred.vermolen@uhasselt.be | - |
local.publisher.place | TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1007/s10237-021-01499-5 | - |
dc.identifier.isi | WOS:000679770100001 | - |
dc.contributor.orcid | van Zuijlen, Paul/0000-0003-3461-8848; Vermolen, | - |
dc.contributor.orcid | Fred/0000-0003-2212-1711; Egberts, Ginger/0000-0003-3601-6496 | - |
dc.identifier.eissn | 1617-7940 | - |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
local.description.affiliation | [Egberts, Ginger] Delft Univ Technol, Delft Inst Appl Math, Delft, Netherlands. | - |
local.description.affiliation | [Egberts, Ginger; Vermolen, Fred] Univ Hasselt, Dept Math & Stat, Res Grp Computat Math CMAT, Hasselt, Belgium. | - |
local.description.affiliation | [van Zuijlen, Paul] Red Cross Hosp, Burn Ctr, Beverwijk, Netherlands. | - |
local.description.affiliation | [van Zuijlen, Paul] Red Cross Hosp, Dept Plast Reconstruct & Hand Surg, Beverwijk, Netherlands. | - |
local.description.affiliation | [van Zuijlen, Paul] Amsterdam UMC, Locat VUmc, Amsterdam Movement Sci, Dept Plast Reconstruct & Hand Surg, Amsterdam, Netherlands. | - |
local.description.affiliation | [van Zuijlen, Paul] Amsterdam UMC, Pediat Surg Ctr, Emma Childrens Hosp, Locat AMC & VUmc, Amsterdam, Netherlands. | - |
local.uhasselt.international | yes | - |
item.fullcitation | EGBERTS, Ginger; VERMOLEN, Fred & van Zuijlen, Paul (2021) Sensitivity and feasibility of a one-dimensional morphoelastic model for post-burn contraction. In: Biomechanics and modeling in mechanobiology (Print), 20(6), p. 2147-2167. | - |
item.contributor | EGBERTS, Ginger | - |
item.contributor | VERMOLEN, Fred | - |
item.contributor | van Zuijlen, Paul | - |
item.validation | ecoom 2022 | - |
item.accessRights | Open Access | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 1617-7959 | - |
crisitem.journal.eissn | 1617-7940 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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Sensitivity and feasibility of a one-dimensional morphoelastic model for post-burn contraction.pdf | Published version | 3.03 MB | Adobe PDF | View/Open |
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