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Title: | Dietary advanced glycation endproducts (AGEs) increase their concentration in plasma and tissues, result in inflammation and modulate gut microbial composition in mice; evidence for reversibility | Authors: | van Dongen, Katja C. W. Linkens, Armand M. A. WETZELS, Suzan WOUTERS, Kristiaan VANMIERLO, Tim van de Waarenburg, Marjo P. H. Scheijen, Jean L. J. M. de Vos, Willem M. Belzer, Clara Schalkwijk, Casper G. |
Issue Date: | 2021 | Publisher: | ELSEVIER | Source: | FOOD RESEARCH INTERNATIONAL, 147 , p. 110547 (Art N° 110547) | Abstract: | Scope: Dietary advanced glycation endproducts (AGEs) are associated with negative biological effects, possibly due to accumulation in plasma and tissues and through modulation of inflammation and gut microbiota. Whether these biological consequences are reversible by limiting dietary AGE intake is unknown. Methods and results: Young healthy C57BL/6 mice were fed a standard chow (n = 10) or a baked chow high AGE-diet (n = 10) (similar to 1.8-6.9 fold increased protein-bound N epsilon-(carboxymethyl)lysine (CML), N epsilon-(1-carboxyethyl) lysine (CEL), and N delta-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1)) for 10 weeks or a switch diet with baked chow for 5 weeks followed by 5 weeks of standard chow (n = 10). We assessed accumulation of AGEs in plasma, kidney, and liver and measured inflammatory markers and gut microbial composition. After 10 weeks of baked chow, a substantial panel of AGEs were increased in plasma, liver, and kidney. These increases were normalized after the switch diet. The inflammatory z-score increased after the baked chow diet. Gut microbial composition differed significantly between groups, with enriched Dubosiella spp. dominating these alterations. Conclusion: A high AGE-diet led to an increase of AGEs in plasma, kidney, and liver and to more inflammation and modification of the gut microbiota. These effects were reversed or discontinued by a diet lower in AGEs. | Notes: | Schalkwijk, CG (corresponding author), Maastricht Univ, Dept Internal Med, Med Ctr, Univ Singel 50, NL-6200 MD Maastricht, Netherlands. katja.vandongen@wur.nl; Armand.linkens@maastrichtuniversity.nl; suzan.wetzels@mumc.nl; kristiaan.wouters@maastrichtuniversity.nl; tim.vanmierlo@uhasselt.be; m.vandewaarenburg@maastrichtuniversity.nl; j.scheijen@maastrichtuniversity.nl; willem.devos@wur.nl; clara.belzer@wur.nl; C.Schalkwijk@maastrichtuniversity.nl |
Keywords: | Dietary advanced glycation endproducts; Gut microbiota; 16S rRNA;sequencing; Ultra-performance liquid chromatography tandem mass;spectrometry | Document URI: | http://hdl.handle.net/1942/34748 | ISSN: | 0963-9969 | e-ISSN: | 1873-7145 | DOI: | 10.1016/j.foodres.2021.110547 | ISI #: | WOS:000684807300013 | Rights: | © 2021 Published by Elsevier Ltd | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2022 |
Appears in Collections: | Research publications |
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1-s20-S0963996921004464-main.pdf Restricted Access | Published version | 3.73 MB | Adobe PDF | View/Open Request a copy |
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