Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/34754
Title: | Concurrent Heavy Metal Exposures and Idiopathic Dilated Cardiomyopathy: A Case-Control Study from the Katanga Mining Area of the Democratic Republic of Congo | Authors: | Malamba-Lez, D Tshala-Katumbay, D BITO, Virginie RIGO, Jean-Michel Kyandabike, RK Yolola, EN Katchunga, P Koba-Bora, B Ngoy-Nkulu, D |
Issue Date: | 2021 | Publisher: | MDPI | Source: | International Journal of Environmental Research and Public Health, 18 (9) (Art N° 4956) | Abstract: | Blood and/or urine levels of 27 heavy metals were determined by ICPMS in 41 patients with dilated cardiomyopathy (DCM) and 29 presumably healthy subjects from the Katanga Copperbelt (KC), in the Democratic Republic of Congo (DRC). After adjusting for age, gender, education level, and renal function, DCM probability was almost maximal for blood concentrations above 0.75 and 150 mu g/dL for arsenic and copper, respectively. Urinary concentrations above 1 for chromium, 20 for copper, 600 for zinc, 30 for selenium, 2 for cadmium, 0.2 for antimony, 0.5 for thallium, and 0.05 for uranium, all in mu g/g of creatinine, were also associated with increased DCM probability. Concurrent and multiple exposures to heavy metals, well beyond permissible levels, are associated with increased probability for DCM. Study findings warrant screening for metal toxicity in case of DCM and prompt public health measures to reduce exposures in the KC, DRC. | Keywords: | environmental exposures;heavy metals;idiopathic dilated cardiomyopathy;Katanga Copperbelt | Document URI: | http://hdl.handle.net/1942/34754 | ISSN: | 1661-7827 | e-ISSN: | 1660-4601 | DOI: | 10.3390/ijerph18094956 | ISI #: | 000650255300001 | Rights: | 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2022 |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
ijerph-18-04956-v3.pdf | Published version | 2.28 MB | Adobe PDF | View/Open |
WEB OF SCIENCETM
Citations
7
checked on Oct 13, 2024
Page view(s)
32
checked on May 30, 2022
Download(s)
8
checked on May 30, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.