Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/34754
Title: Concurrent Heavy Metal Exposures and Idiopathic Dilated Cardiomyopathy: A Case-Control Study from the Katanga Mining Area of the Democratic Republic of Congo
Authors: Malamba-Lez, D
Tshala-Katumbay, D
BITO, Virginie 
RIGO, Jean-Michel 
Kyandabike, RK
Yolola, EN
Katchunga, P
Koba-Bora, B
Ngoy-Nkulu, D
Issue Date: 2021
Publisher: MDPI
Source: International Journal of Environmental Research and Public Health, 18 (9) , p. 4956
Abstract: Blood and/or urine levels of 27 heavy metals were determined by ICPMS in 41 patients with dilated cardiomyopathy (DCM) and 29 presumably healthy subjects from the Katanga Copperbelt (KC), in the Democratic Republic of Congo (DRC). After adjusting for age, gender, education level, and renal function, DCM probability was almost maximal for blood concentrations above 0.75 and 150 mu g/dL for arsenic and copper, respectively. Urinary concentrations above 1 for chromium, 20 for copper, 600 for zinc, 30 for selenium, 2 for cadmium, 0.2 for antimony, 0.5 for thallium, and 0.05 for uranium, all in mu g/g of creatinine, were also associated with increased DCM probability. Concurrent and multiple exposures to heavy metals, well beyond permissible levels, are associated with increased probability for DCM. Study findings warrant screening for metal toxicity in case of DCM and prompt public health measures to reduce exposures in the KC, DRC.
Keywords: environmental exposures;heavy metals;idiopathic dilated cardiomyopathy;Katanga Copperbelt
Document URI: http://hdl.handle.net/1942/34754
ISSN: 1661-7827
e-ISSN: 1660-4601
DOI: 10.3390/ijerph18094956
ISI #: 000650255300001
Rights: Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/4.0/).
Category: A1
Type: Journal Contribution
Validations: ecoom 2022
Appears in Collections:Research publications

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