Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/34791
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dc.contributor.authorBauckneht, Matteo-
dc.contributor.authorChincarini, Andrea-
dc.contributor.authorBrendel, Matthias-
dc.contributor.authorRominger, Axel-
dc.contributor.authorBRUFFAERTS, Rose-
dc.contributor.authorVandenberghe, Rik-
dc.contributor.authorKramberger, Milica G.-
dc.contributor.authorTrost, Maja-
dc.contributor.authorGaribotto, Valentina-
dc.contributor.authorNicastro, Nicolas-
dc.contributor.authorFrisoni, Giovanni B.-
dc.contributor.authorLemstra, Afina W.-
dc.contributor.authorBerckel, Bart N. M.-
dc.contributor.authorPilotto, Andrea-
dc.contributor.authorPadovani, Alessandro-
dc.contributor.authorOchoa-Figueroa, Miguel A.-
dc.contributor.authorDavidsson, Anette-
dc.contributor.authorCamacho, Valle-
dc.contributor.authorPeira, Enrico-
dc.contributor.authorArnaldi, Dario-
dc.contributor.authorPardini, Matteo-
dc.contributor.authorDonegani, Maria Isabella-
dc.contributor.authorRaffa, Stefano-
dc.contributor.authorMiceli, Alberto-
dc.contributor.authorSambuceti, Gianmario-
dc.contributor.authorAarsland, Dag-
dc.contributor.authorNobili, Flavio-
dc.contributor.authorMorbelli, Silvia-
dc.contributor.authorBeyer, Leonie-
dc.date.accessioned2021-09-02T14:38:04Z-
dc.date.available2021-09-02T14:38:04Z-
dc.date.issued2021-
dc.date.submitted2021-09-02T10:06:35Z-
dc.identifier.citationAlzheimer's & dementia, 17 (8) , p. 1277 -1286-
dc.identifier.urihttp://hdl.handle.net/1942/34791-
dc.description.abstractIntroduction We assessed the influence of education as a proxy of cognitive reserve and age on the dementia with Lewy bodies (DLB) metabolic pattern. Methods Brain 18F-fluorodeoxyglucose positron emission tomography and clinical/demographic information were available in 169 probable DLB patients included in the European DLB-consortium database. Principal component analysis identified brain regions relevant to local data variance. A linear regression model was applied to generate age- and education-sensitive maps corrected for Mini-Mental State Examination score, sex (and either education or age). Results Age negatively covaried with metabolism in bilateral middle and superior frontal cortex, anterior and posterior cingulate, reducing the expression of the DLB-typical cingulate island sign (CIS). Education negatively covaried with metabolism in the left inferior parietal cortex and precuneus (making the CIS more prominent). Discussion These findings point out the importance of tailoring interpretation of DLB biomarkers considering the concomitant effect of individual, non-disease-related variables such as age and cognitive reserve.-
dc.description.sponsorshipM.B. and S.M. were supported by grants from the ItalianMinistry of Health - 5×1000 funds 2016; R.B. is a senior postdoctoral fellow of the Research Foundation Flanders (FWO); V.G. was supported by the Swiss National Science Foundation (projects 320030_185028 and 320030_169876). This paper represents independent research partly funded by the National Institute for Health Research (NIHR) Biomedical Research Centre at South London andMaudsley NHS Foundation Trust and King’s College London. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care.-
dc.language.isoen-
dc.publisherWILEY-
dc.rights2021 the Alzheimer’s Association-
dc.subject.otherbiomarkers-
dc.subject.othercognitive reserve-
dc.subject.otherdementia with Lewy bodies-
dc.subject.otherfluorodeoxyglucose positron emission tomography-
dc.titleAssociations among education, age, and the dementia with Lewy bodies (DLB) metabolic pattern: A European-DLB consortium project-
dc.typeJournal Contribution-
dc.identifier.epage1286-
dc.identifier.issue8-
dc.identifier.spage1277-
dc.identifier.volume17-
local.format.pages10-
local.bibliographicCitation.jcatA1-
dc.description.notesMorbelli, S (corresponding author), Univ Genoa, Dept Hlth Sci DISSAL, IRCCS Osped Policlin San Martino, Nucl Med Unit, Largo R Benzi 10, I-16132 Genoa, Italy.-
dc.description.notessilvia.morbelli@unige.it-
local.publisher.place111 RIVER ST, HOBOKEN 07030-5774, NJ USA-
local.type.refereedRefereed-
local.type.specifiedArticle-
dc.identifier.doi10.1002/alz.12294-
dc.identifier.isiWOS:000685986400002-
dc.contributor.orcidBauckneht, Matteo/0000-0002-1937-9116; Pilotto,-
dc.contributor.orcidAndrea/0000-0003-2029-6606; Aarsland, Dag/0000-0001-6314-216X-
local.provider.typewosris-
local.uhasselt.uhpubyes-
local.description.affiliation[Bauckneht, Matteo; Sambuceti, Gianmario; Morbelli, Silvia] IRCCS Osped Policlin San Martino, Nucl Med Unit, Genoa, Italy.-
local.description.affiliation[Chincarini, Andrea; Peira, Enrico] Natl Inst Nucl Phys INFN, Genoa Sect, Genoa, Italy.-
local.description.affiliation[Brendel, Matthias; Rominger, Axel; Beyer, Leonie] Ludwig Maximilians Univ Munchen, Dept Nucl Med, Univ Hosp, Munich, Germany.-
local.description.affiliation[Rominger, Axel] Univ Hosp Bern, Dept Nucl Med, Inselspital, Bern, Switzerland.-
local.description.affiliation[Bruffaerts, Rose; Vandenberghe, Rik] Katholieke Univ Leuven, Lab Cognit Neurol, Dept Neurosci, Leuven, Belgium.-
local.description.affiliation[Bruffaerts, Rose; Vandenberghe, Rik] Univ Hosp Leuven, Neurol Dept, Leuven, Belgium.-
local.description.affiliation[Bruffaerts, Rose] Hasselt Univ, Biomed Res Inst, Hasselt, Belgium.-
local.description.affiliation[Kramberger, Milica G.; Trost, Maja] Univ Med Ctr Ljubljana, Dept Neurol, Ljubljana, Slovenia.-
local.description.affiliation[Kramberger, Milica G.; Trost, Maja] Univ Ljubljana, Fac Med, Ljubljana, Slovenia.-
local.description.affiliation[Garibotto, Valentina] Univ Geneva, Geneva Univ Hosp, Div Nucl Med & Mol Imaging, Geneva, Switzerland.-
local.description.affiliation[Garibotto, Valentina] Univ Geneva, NIMT Lab, Geneva, Switzerland.-
local.description.affiliation[Nicastro, Nicolas] Geneva Univ Hosp, Dept Clin Neurosci, Geneva, Switzerland.-
local.description.affiliation[Nicastro, Nicolas] Univ Cambridge, Dept Psychiat, Cambridge, England.-
local.description.affiliation[Frisoni, Giovanni B.] Geneva Univ Hosp, Dept Psychiat, LANVIE Lab Neuroimagerie Vieillissement, Geneva, Switzerland.-
local.description.affiliation[Lemstra, Afina W.] Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Dept Neurol, Amsterdam Neurosci, Amsterdam, Netherlands.-
local.description.affiliation[Berckel, Bart N. M.] Vrije Univ Amsterdam, Dept Radiol & Nucl Med, Amsterdam UMC, Amsterdam Neurosci, Amsterdam, Netherlands.-
local.description.affiliation[Pilotto, Andrea; Padovani, Alessandro] Univ Brescia, Dept Clin & Expt Sci, Neurol Unit, Brescia, Italy.-
local.description.affiliation[Pilotto, Andrea] Isidoro Hosp, Parkinsons Dis Rehabil Ctr, FERB ONLUS S, Trescore Balneario, Italy.-
local.description.affiliation[Ochoa-Figueroa, Miguel A.; Davidsson, Anette] Linkoping Univ, Dept Clin Physiol Linkoping, Dept Hlth Med & Caring Sci, Linkoping, Sweden.-
local.description.affiliation[Ochoa-Figueroa, Miguel A.] Linkoping Univ Hosp, Dept Diagnost Radiol, Linkoping, Sweden.-
local.description.affiliation[Ochoa-Figueroa, Miguel A.] Linkoping Univ, Ctr Med Image Sci & Visualizat CMIV, Linkoping, Sweden.-
local.description.affiliation[Camacho, Valle] Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Serv Med Nucl, Barcelona, Spain.-
local.description.affiliation[Peira, Enrico; Arnaldi, Dario; Pardini, Matteo; Nobili, Flavio] Univ Genoa, Dept Neurosci DINOGMI, Genoa, Italy.-
local.description.affiliation[Arnaldi, Dario; Pardini, Matteo; Nobili, Flavio] IRCCS Osped Policlin San Martino, Clin Neurol, Genoa, Italy.-
local.description.affiliation[Donegani, Maria Isabella; Raffa, Stefano; Miceli, Alberto; Sambuceti, Gianmario; Morbelli, Silvia] Univ Genoa, Dept Hlth Sci, Genoa, Italy.-
local.description.affiliation[Aarsland, Dag] Stavanger Univ Hosp, Ctr Age Related Med SESAM, Stavanger, Norway.-
local.description.affiliation[Aarsland, Dag] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Old Age Psychiat, London, England.-
local.uhasselt.internationalyes-
item.fullcitationBauckneht, Matteo; Chincarini, Andrea; Brendel, Matthias; Rominger, Axel; BRUFFAERTS, Rose; Vandenberghe, Rik; Kramberger, Milica G.; Trost, Maja; Garibotto, Valentina; Nicastro, Nicolas; Frisoni, Giovanni B.; Lemstra, Afina W.; Berckel, Bart N. M.; Pilotto, Andrea; Padovani, Alessandro; Ochoa-Figueroa, Miguel A.; Davidsson, Anette; Camacho, Valle; Peira, Enrico; Arnaldi, Dario; Pardini, Matteo; Donegani, Maria Isabella; Raffa, Stefano; Miceli, Alberto; Sambuceti, Gianmario; Aarsland, Dag; Nobili, Flavio; Morbelli, Silvia & Beyer, Leonie (2021) Associations among education, age, and the dementia with Lewy bodies (DLB) metabolic pattern: A European-DLB consortium project. In: Alzheimer's & dementia, 17 (8) , p. 1277 -1286.-
item.validationecoom 2022-
item.accessRightsRestricted Access-
item.fulltextWith Fulltext-
item.contributorBauckneht, Matteo-
item.contributorChincarini, Andrea-
item.contributorBrendel, Matthias-
item.contributorRominger, Axel-
item.contributorBRUFFAERTS, Rose-
item.contributorVandenberghe, Rik-
item.contributorKramberger, Milica G.-
item.contributorTrost, Maja-
item.contributorGaribotto, Valentina-
item.contributorNicastro, Nicolas-
item.contributorFrisoni, Giovanni B.-
item.contributorLemstra, Afina W.-
item.contributorBerckel, Bart N. M.-
item.contributorPilotto, Andrea-
item.contributorPadovani, Alessandro-
item.contributorOchoa-Figueroa, Miguel A.-
item.contributorDavidsson, Anette-
item.contributorCamacho, Valle-
item.contributorPeira, Enrico-
item.contributorArnaldi, Dario-
item.contributorPardini, Matteo-
item.contributorDonegani, Maria Isabella-
item.contributorRaffa, Stefano-
item.contributorMiceli, Alberto-
item.contributorSambuceti, Gianmario-
item.contributorAarsland, Dag-
item.contributorNobili, Flavio-
item.contributorMorbelli, Silvia-
item.contributorBeyer, Leonie-
crisitem.journal.issn1552-5260-
crisitem.journal.eissn1552-5279-
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