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http://hdl.handle.net/1942/34796
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DC Field | Value | Language |
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dc.contributor.author | BONGAERTS, Eva | - |
dc.contributor.author | Aengenheister, L | - |
dc.contributor.author | Dugershaw, BB | - |
dc.contributor.author | Manser, P | - |
dc.contributor.author | Roeffaers, MBJ | - |
dc.contributor.author | AMELOOT, Marcel | - |
dc.contributor.author | NAWROT, Tim | - |
dc.contributor.author | BOVE, Hannelore | - |
dc.contributor.author | Buerki-Thurnherr, T | - |
dc.date.accessioned | 2021-09-06T08:42:05Z | - |
dc.date.available | 2021-09-06T08:42:05Z | - |
dc.date.issued | 2021 | - |
dc.date.submitted | 2021-08-30T14:01:24Z | - |
dc.identifier.citation | Journal of nanobiotechnology, 19 (1) , (Art N° 144) | - |
dc.identifier.uri | http://hdl.handle.net/1942/34796 | - |
dc.description.abstract | BackgroundPregnant women and developing fetuses comprise a particularly vulnerable population as multiple studies have shown associations between prenatal air pollution exposure and adverse pregnancy outcomes. However, the mechanisms underlying the observed developmental toxicity are mostly unknown, in particular, if pollution particles can cross the human placenta to reach the fetal circulation.ResultsHere, we investigated the accumulation and translocation of diesel exhaust particles (DEPs), as a model particle for combustion-derived pollution, in human perfused placentae using label-free detection by femtosecond pulsed laser illumination. The results do not reveal a significant particle transfer across term placentae within 6 h of perfusion. However, DEPs accumulate in placental tissue, especially in the syncytiotrophoblast layer that mediates a wealth of essential functions to support and maintain a successful pregnancy. Furthermore, DEPs are found in placental macrophages and fetal endothelial cells, showing that some particles can overcome the syncytiotrophoblasts to reach the fetal capillaries. Few particles are also observed inside fetal microvessels.ConclusionsOverall, we show that DEPs accumulate in key cell types of the placental tissue and can cross the human placenta, although in limited amounts. These findings are crucial for risk assessment and protection of pregnant women and highlight the urgent need for further research on the direct and indirect placenta-mediated developmental toxicity of ambient particulates. | - |
dc.description.sponsorship | This work received fnancial support from the Flemish Scientifc Research Foundation (Grant no 1150920N, G082317N, and 12P6819N) and the Swiss National Science Foundation (Grant no 31003A_179337 and IZSEZ0_193948). The detection equipment was funded by the Interuniversity Attraction Poles Program (P7/05) initiated by the Belgian Science Policy Ofce and the INCALO project (ERC-PoC). Acknowledgements The authors would like to acknowledge all participants of the study. In addition, we owe special thanks to the nurses, midwives, and doctors involved in placenta collection. | - |
dc.language.iso | en | - |
dc.publisher | BMC | - |
dc.rights | The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativeco mmons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/ zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data | - |
dc.subject.other | Environmental pollution | - |
dc.subject.other | Diesel exhaust particles | - |
dc.subject.other | In utero exposure | - |
dc.subject.other | Ex vivo placental perfusion | - |
dc.subject.other | Nanosafety | - |
dc.title | Label-free detection of uptake, accumulation, and translocation of diesel exhaust particles in ex vivo perfused human placenta | - |
dc.type | Journal Contribution | - |
dc.identifier.issue | 1 | - |
dc.identifier.volume | 19 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.other | The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request. | - |
local.publisher.place | CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 144 | - |
dc.identifier.doi | 10.1186/s12951-021-00886-5 | - |
dc.identifier.pmid | 34001140 | - |
dc.identifier.isi | 000655044700006 | - |
local.provider.type | Web of Science | - |
local.uhasselt.international | yes | - |
item.contributor | BONGAERTS, Eva | - |
item.contributor | Aengenheister, L | - |
item.contributor | Dugershaw, BB | - |
item.contributor | Manser, P | - |
item.contributor | Roeffaers, MBJ | - |
item.contributor | AMELOOT, Marcel | - |
item.contributor | NAWROT, Tim | - |
item.contributor | BOVE, Hannelore | - |
item.contributor | Buerki-Thurnherr, T | - |
item.validation | ecoom 2022 | - |
item.fullcitation | BONGAERTS, Eva; Aengenheister, L; Dugershaw, BB; Manser, P; Roeffaers, MBJ; AMELOOT, Marcel; NAWROT, Tim; BOVE, Hannelore & Buerki-Thurnherr, T (2021) Label-free detection of uptake, accumulation, and translocation of diesel exhaust particles in ex vivo perfused human placenta. In: Journal of nanobiotechnology, 19 (1) , (Art N° 144). | - |
item.accessRights | Open Access | - |
item.fulltext | With Fulltext | - |
crisitem.journal.eissn | 1477-3155 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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s12951-021-00886-5.pdf | Published version | 1.27 MB | Adobe PDF | View/Open |
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