Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/3496
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dc.contributor.authorSchacht, E-
dc.contributor.authorGevaert, A-
dc.contributor.authorKenawy, ER-
dc.contributor.authorMolly, K-
dc.contributor.authorVerstraete, W-
dc.contributor.authorADRIAENSENS, Peter-
dc.contributor.authorCARLEER, Robert-
dc.contributor.authorGELAN, Jan-
dc.date.accessioned2007-11-28T15:38:46Z-
dc.date.available2007-11-28T15:38:46Z-
dc.date.issued1996-
dc.identifier.citationJOURNAL OF CONTROLLED RELEASE, 39(2-3). p. 327-338-
dc.identifier.issn0168-3659-
dc.identifier.urihttp://hdl.handle.net/1942/3496-
dc.description.abstractAzo-linked polymeric prodrugs of 5-aminosalicylic acid (5-ASA) were prepared and evaluated in simulated human intestinal microbial ecosystem. Release of 5-ASA was demonstrated. Polyamides containing azo groups in the backbone were prepared and tested in vitro in a reductive buffer or in the bioreactor medium. It was demonstrated that for the hydrophobic polymer reduction stops at the hydrazine stage whereas for a hydrophilic analogue reduction with formation of amines occurred.-
dc.language.isoen-
dc.publisherELSEVIER SCIENCE BV-
dc.subject.other5-aminosalicylic acid; azo polymer; prodrug colon targeting; coating; degradation; human colon-
dc.titlePolymers for colon specific drug delivery-
dc.typeJournal Contribution-
dc.identifier.epage338-
dc.identifier.issue2-3-
dc.identifier.spage327-
dc.identifier.volume39-
local.format.pages12-
dc.description.notesMICROBIAL ECOL LAB,B-9000 GHENT,BELGIUM. UNIV LIMBURG,MAT RES INST,B-3590 DIEPENBEEK,BELGIUM.Schacht, E, STATE UNIV GHENT,BIOMAT & POLYMER RES GRP,KRIJGSLAAN 281,B-9000 GHENT,BELGIUM.-
local.type.refereedRefereed-
local.type.specifiedArticle-
dc.bibliographicCitation.oldjcatA1-
dc.identifier.doi10.1016/0168-3659(95)00184-0-
dc.identifier.isiA1996UT43200022-
item.accessRightsClosed Access-
item.contributorSchacht, E-
item.contributorGevaert, A-
item.contributorKenawy, ER-
item.contributorMolly, K-
item.contributorVerstraete, W-
item.contributorADRIAENSENS, Peter-
item.contributorCARLEER, Robert-
item.contributorGELAN, Jan-
item.fulltextNo Fulltext-
item.fullcitationSchacht, E; Gevaert, A; Kenawy, ER; Molly, K; Verstraete, W; ADRIAENSENS, Peter; CARLEER, Robert & GELAN, Jan (1996) Polymers for colon specific drug delivery. In: JOURNAL OF CONTROLLED RELEASE, 39(2-3). p. 327-338.-
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