Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/3496
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Schacht, E | - |
dc.contributor.author | Gevaert, A | - |
dc.contributor.author | Kenawy, ER | - |
dc.contributor.author | Molly, K | - |
dc.contributor.author | Verstraete, W | - |
dc.contributor.author | ADRIAENSENS, Peter | - |
dc.contributor.author | CARLEER, Robert | - |
dc.contributor.author | GELAN, Jan | - |
dc.date.accessioned | 2007-11-28T15:38:46Z | - |
dc.date.available | 2007-11-28T15:38:46Z | - |
dc.date.issued | 1996 | - |
dc.identifier.citation | JOURNAL OF CONTROLLED RELEASE, 39(2-3). p. 327-338 | - |
dc.identifier.issn | 0168-3659 | - |
dc.identifier.uri | http://hdl.handle.net/1942/3496 | - |
dc.description.abstract | Azo-linked polymeric prodrugs of 5-aminosalicylic acid (5-ASA) were prepared and evaluated in simulated human intestinal microbial ecosystem. Release of 5-ASA was demonstrated. Polyamides containing azo groups in the backbone were prepared and tested in vitro in a reductive buffer or in the bioreactor medium. It was demonstrated that for the hydrophobic polymer reduction stops at the hydrazine stage whereas for a hydrophilic analogue reduction with formation of amines occurred. | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject.other | 5-aminosalicylic acid; azo polymer; prodrug colon targeting; coating; degradation; human colon | - |
dc.title | Polymers for colon specific drug delivery | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 338 | - |
dc.identifier.issue | 2-3 | - |
dc.identifier.spage | 327 | - |
dc.identifier.volume | 39 | - |
local.format.pages | 12 | - |
dc.description.notes | MICROBIAL ECOL LAB,B-9000 GHENT,BELGIUM. UNIV LIMBURG,MAT RES INST,B-3590 DIEPENBEEK,BELGIUM.Schacht, E, STATE UNIV GHENT,BIOMAT & POLYMER RES GRP,KRIJGSLAAN 281,B-9000 GHENT,BELGIUM. | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.bibliographicCitation.oldjcat | A1 | - |
dc.identifier.doi | 10.1016/0168-3659(95)00184-0 | - |
dc.identifier.isi | A1996UT43200022 | - |
item.accessRights | Closed Access | - |
item.contributor | Schacht, E | - |
item.contributor | Gevaert, A | - |
item.contributor | Kenawy, ER | - |
item.contributor | Molly, K | - |
item.contributor | Verstraete, W | - |
item.contributor | ADRIAENSENS, Peter | - |
item.contributor | CARLEER, Robert | - |
item.contributor | GELAN, Jan | - |
item.fulltext | No Fulltext | - |
item.fullcitation | Schacht, E; Gevaert, A; Kenawy, ER; Molly, K; Verstraete, W; ADRIAENSENS, Peter; CARLEER, Robert & GELAN, Jan (1996) Polymers for colon specific drug delivery. In: JOURNAL OF CONTROLLED RELEASE, 39(2-3). p. 327-338. | - |
Appears in Collections: | Research publications |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.