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http://hdl.handle.net/1942/35401
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DC Field | Value | Language |
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dc.contributor.author | ROBIJNS, Jolien | - |
dc.contributor.author | LODEWIJCKX, Joy | - |
dc.contributor.author | Van Bever, Leen | - |
dc.contributor.author | Puts, Sofie | - |
dc.contributor.author | Timmermans, An | - |
dc.contributor.author | Noe, Leen | - |
dc.contributor.author | Vanmechelen, Sofie | - |
dc.contributor.author | Govers, Mieke | - |
dc.contributor.author | Van de Werf, Evelyn | - |
dc.contributor.author | MAES, Annelies | - |
dc.contributor.author | BULENS, Paul | - |
dc.contributor.author | MEBIS, Jeroen | - |
dc.contributor.author | Claes, Stefan | - |
dc.contributor.author | Pannekoeke, Luc | - |
dc.date.accessioned | 2021-09-17T09:55:41Z | - |
dc.date.available | 2021-09-17T09:55:41Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2021-09-16T10:55:10Z | - |
dc.identifier.citation | LASERS IN SURGERY AND MEDICINE; 54 (3) , p. 374-383 | - |
dc.identifier.issn | 0196-8092 | - |
dc.identifier.uri | http://hdl.handle.net/1942/35401 | - |
dc.description.abstract | Objectives To evaluate the efficacy of photobiomodulation therapy in breast cancer patients post-lumpectomy undergoing hypofractionated whole-breast irradiation (HF-WBI) for the prevention and management of acute radiodermatitis (ARD). Materials and Methods A randomized, multicentric clinical trial (LABRA trial, NCT03924011) was set up at the Limburg Oncology Center, including the Jessa Hospital (Hasselt, BE) and Ziekenhuis Oost-Limburg (Genk, BE). A total of 71 breast cancer patients planned to undergo HF-WBI were randomized to one of the two study arms: the control group (n = 32) or the PBM group (n = 39). The PBM group received the standard institutional skincare combined with PBM (2x/week) during the complete radiotherapy (RT) course. Patients in the control group received the standard skincare combined with placebo treatment (2x/week). Patients' skin reactions were evaluated weekly during the RT treatment by using the modified version of the Radiation Therapy Oncology Group (RTOG) criteria. Results At week 3 of RT, one patient presented a grade 2 and one patient a grade 3 skin reaction in the control group, while in the PBM group, all patients still presented grade 1 ARD. At the final RT session 28% of the patients presenting grade 2-3 ARD, while in the PBM group 10% presented grade 2 and no grade 3 ARD. PBM reduced the incidence of severe ARD by 18%. However, the difference was not significant (p = 0.053). Conclusion Based on the LABRA trial results, PBM seems not able to reduce the incidence of severe ARD in breast cancer patients undergoing HF-WBI. Research in a larger patient population is recommended. | - |
dc.description.sponsorship | ASA Srl; Kom op Tegen Kanker, Stand up to Cancer, the Flemish cancer society; Limburgs Kankerfonds This study is part of the Limburg Clinical Research Center (LCRC) UHasselt‐ZOL‐Jessa, financially supported by the foundation Limburg Sterk Merk, province of Limburg, Flemish government, Hasselt University, Ziekenhuis Oost‐Limburg, and Jessa Hospital. Additionally, this study is supported by Kom op tegen Kanker (Stand up to Cancer), the Flemish cancer society, Limburgs Kankerfonds, and ASA Srl. | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.rights | 2021 Wiley Periodicals LLC | - |
dc.subject.other | acute radiodermatitis | - |
dc.subject.other | breast cancer | - |
dc.subject.other | dermatology | - |
dc.subject.other | photobiomodulation therapy | - |
dc.subject.other | radiotherapy | - |
dc.subject.other | skin | - |
dc.title | Photobiomodulation therapy for the prevention of acute radiation dermatitis in breast cancer patients undergoing hypofractioned whole‐breast irradiation (LABRA trial) | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 383 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 374 | - |
dc.identifier.volume | 54 | - |
local.format.pages | 10 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Robijns, J (corresponding author), Hasselt Univ, Fac Med & Life Sci, Martelarenlaan 42, B-3500 Hasselt, Belgium. | - |
dc.description.notes | Jolien.robijns@uhasselt.be | - |
local.publisher.place | 111 RIVER ST, HOBOKEN 07030-5774, NJ USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1002/lsm.23475 | - |
dc.identifier.pmid | 34481420 | - |
dc.identifier.isi | WOS:000693508200001 | - |
dc.contributor.orcid | Robijns, Jolien/0000-0002-6286-1581; puts, sofie/0000-0002-5774-7506 | - |
dc.identifier.eissn | 1096-9101 | - |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
local.description.affiliation | [Robijns, Jolien; Lodewijckx, Joy; Puts, Sofie; Vanmechelen, Sofie; Mebis, Jeroen] Hasselt Univ, Fac Med & Life Sci, Martelarenlaan 42, B-3500 Hasselt, Belgium. | - |
local.description.affiliation | [Van Bever, Leen; Claes, Stefan; Pannekoeke, Luc; Noe, Leen; Maes, Annelies; Bulens, Paul] Jessa Hosp, Limburg Oncol Ctr, Campus Virga Jesse, Hasselt, Belgium. | - |
local.description.affiliation | [Timmermans, An] Jessa Hosp, Dept Dermatol, Hasselt, Belgium. | - |
local.description.affiliation | [Govers, Mieke; Van de Werf, Evelyn; Maes, Annelies] Ziekenhuis Oost Limburg, Limburg Oncol Ctr, Genk, Belgium. | - |
local.description.affiliation | [Mebis, Jeroen] Jessa Hosp, Dept Med Oncol, Hasselt, Belgium. | - |
local.uhasselt.international | no | - |
item.validation | ecoom 2022 | - |
item.contributor | ROBIJNS, Jolien | - |
item.contributor | LODEWIJCKX, Joy | - |
item.contributor | Van Bever, Leen | - |
item.contributor | Puts, Sofie | - |
item.contributor | Timmermans, An | - |
item.contributor | Noe, Leen | - |
item.contributor | Vanmechelen, Sofie | - |
item.contributor | Govers, Mieke | - |
item.contributor | Van de Werf, Evelyn | - |
item.contributor | MAES, Annelies | - |
item.contributor | BULENS, Paul | - |
item.contributor | MEBIS, Jeroen | - |
item.contributor | Claes, Stefan | - |
item.contributor | Pannekoeke, Luc | - |
item.accessRights | Restricted Access | - |
item.fullcitation | ROBIJNS, Jolien; LODEWIJCKX, Joy; Van Bever, Leen; Puts, Sofie; Timmermans, An; Noe, Leen; Vanmechelen, Sofie; Govers, Mieke; Van de Werf, Evelyn; MAES, Annelies; BULENS, Paul; MEBIS, Jeroen; Claes, Stefan & Pannekoeke, Luc (2022) Photobiomodulation therapy for the prevention of acute radiation dermatitis in breast cancer patients undergoing hypofractioned whole‐breast irradiation (LABRA trial). In: LASERS IN SURGERY AND MEDICINE; 54 (3) , p. 374-383. | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 0196-8092 | - |
crisitem.journal.eissn | 1096-9101 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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Lasers Surg Med - 2021 - Robijns - Photobiomodulation therapy for the prevention of acute radiation dermatitis in breast.pdf Restricted Access | Published version | 367.93 kB | Adobe PDF | View/Open Request a copy |
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