Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/35450
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dc.contributor.authorRoos, I-
dc.contributor.authorLeray, E-
dc.contributor.authorFrascoli, F-
dc.contributor.authorCasey, R-
dc.contributor.authorBrown, JWL-
dc.contributor.authorHorakova, D-
dc.contributor.authorHavrdova, EK-
dc.contributor.authorDebouverie, M-
dc.contributor.authorTrojano, M-
dc.contributor.authorPatti, F-
dc.contributor.authorIzquierdo, G-
dc.contributor.authorEichau, S-
dc.contributor.authorEdan, G-
dc.contributor.authorPrat, A-
dc.contributor.authorGirard, M-
dc.contributor.authorDuquette, P-
dc.contributor.authorOnofrj, M-
dc.contributor.authorLugaresi, A-
dc.contributor.authorGrammond, P-
dc.contributor.authorCiron, J-
dc.contributor.authorRuet, A-
dc.contributor.authorOzakbas, S-
dc.contributor.authorDe Seze, J-
dc.contributor.authorLouapre, C-
dc.contributor.authorZephir, H-
dc.contributor.authorSa, MJ-
dc.contributor.authorSola, P-
dc.contributor.authorFerraro, D-
dc.contributor.authorLabauge, P-
dc.contributor.authorDefer, G-
dc.contributor.authorBergamaschi, R-
dc.contributor.authorLebrun-Frenay, C-
dc.contributor.authorBoz, C-
dc.contributor.authorCartechini, E-
dc.contributor.authorMoreau, T-
dc.contributor.authorLaplaud, D-
dc.contributor.authorLechner-Scott, J-
dc.contributor.authorGrand'Maison, F-
dc.contributor.authorGerlach, O-
dc.contributor.authorTerzi, M-
dc.contributor.authorGranella, F-
dc.contributor.authorAlroughani, R-
dc.contributor.authorIuliano, G-
dc.contributor.authorVan Pesch, V-
dc.contributor.authorVAN WIJMEERSCH, Bart-
dc.contributor.authorLa Spitaleri, D-
dc.contributor.authorSoysal, A-
dc.contributor.authorBerger, E.-
dc.contributor.authorPrevost, J-
dc.contributor.authorAguera-Morales, E-
dc.contributor.authorMcCombe, P-
dc.contributor.authorTrivino, TC-
dc.contributor.authorClavelou, P-
dc.contributor.authorPelletier, J-
dc.contributor.authorTurkoglu, R-
dc.contributor.authorStankoff, B-
dc.contributor.authorGout, O-
dc.contributor.authorThouvenot, E-
dc.contributor.authorHeinzlef, O-
dc.contributor.authorSidhom, Y-
dc.contributor.authorGouider, R-
dc.contributor.authorCsepany, T-
dc.contributor.authorBourre, B-
dc.contributor.authorAl Khedr, A-
dc.contributor.authorCasez, O-
dc.contributor.authorCabre, P-
dc.contributor.authorMontcuquet, A-
dc.contributor.authorWahab, A-
dc.contributor.authorCamdessanche, JP-
dc.contributor.authorMaurousset, A-
dc.contributor.authorPatry, I-
dc.contributor.authorHankiewicz, K-
dc.contributor.authorPottier, C-
dc.contributor.authorMaubeuge, N-
dc.contributor.authorLabeyrie, C-
dc.contributor.authorNifle, C-
dc.contributor.authorColes, A-
dc.contributor.authorMalpas, CB-
dc.contributor.authorVukusic, S-
dc.contributor.authorButzkueven, H-
dc.contributor.authorKalincik, T-
dc.date.accessioned2021-09-27T09:52:51Z-
dc.date.available2021-09-27T09:52:51Z-
dc.date.issued2021-
dc.date.submitted2021-09-17T13:14:39Z-
dc.identifier.citationMultiple sclerosis journal, experimental, translational and clinical, 27(12), p. 1838-1851-
dc.identifier.issn1352-4585-
dc.identifier.urihttp://hdl.handle.net/1942/35450-
dc.description.abstractBackground: A delayed onset of treatment effect, termed therapeutic lag, may influence the assessment of treatment response in some patient subgroups. Objectives: The objective of this study is to explore the associations of patient and disease characteristics with therapeutic lag on relapses and disability accumulation. Methods: Data from MSBase, a multinational multiple sclerosis (MS) registry, and OFSEP, the French MS registry, were used. Patients diagnosed with MS, minimum 1 year of exposure to MS treatment and 3 years of pre-treatment follow-up, were included in the analysis. Studied outcomes were incidence of relapses and disability accumulation. Therapeutic lag was calculated using an objective, validated method in subgroups stratified by patient and disease characteristics. Therapeutic lag under specific circumstances was then estimated in subgroups defined by combinations of clinical and demographic determinants. Results: High baseline disability scores, annualised relapse rate (ARR) > 1 and male sex were associated with longer therapeutic lag on disability progression in sufficiently populated groups: females with expanded disability status scale (EDSS) < 6 and ARR < 1 had mean lag of 26.6 weeks (95% CI = 18.2-34.9), males with EDSS < 6 and ARR < 1 31.0 weeks (95% CI = 25.3-36.8), females with EDSS < 6 and ARR > 1 44.8 weeks (95% CI = 24.5-65.1), and females with EDSS > 6 and ARR < 1 54.3 weeks (95% CI = 47.2-61.5). Conclusions: Pre-treatment EDSS and ARR are the most important determinants of therapeutic lag.-
dc.description.sponsorshipThe author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: This study was supported by the EDMUS Foundation and NHMRC (1140766, 1129189 and 1157717). I.R. was supported by an MSIF-ARSEP McDonald fellowship grant and a Melbourne Research Scholarship. The MSBase Foundation is a not-for-profit organisation that receives support from Biogen, Novartis, Merck, Roche, Teva and Sanofi-Genzyme. The study was conducted separately and apart from the guidance of the sponsors. The Observatoire Français de la Sclérose en Plaques (OFSEP) was supported by a grant provided by the French State and handled by the ‘Agence Nationale de la Recherche’, within the framework of the ‘Investments for the Future’ programme, under the reference ANR-10-COHO-002, by the Eugène Devic EDMUS Foundation against multiple sclerosis and by the ARSEP Foundation. The authors wish to thank all patients and their carers who have participated in this study and who have contributed data to the MSBase and OFSEP cohorts. Contributing members of OFSEP and the MSBase Study Group is given in the online supplement.-
dc.language.isoen-
dc.publisherSAGE PUBLICATIONS LTD-
dc.rightsThe Author(s), 2021. Article reuse guidelines: sagepub.com/journalspermissions-
dc.subject.otherNeurology-
dc.subject.othermultiple sclerosis-
dc.subject.otherobservational study-
dc.subject.othertherapeutic lag-
dc.titleDeterminants of therapeutic lag in multiple sclerosis-
dc.typeJournal Contribution-
dc.identifier.epage1851-
dc.identifier.issue12-
dc.identifier.spage1838-
dc.identifier.volume27-
local.bibliographicCitation.jcatA1-
local.publisher.place1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND-
local.type.refereedRefereed-
local.type.specifiedArticle-
dc.identifier.doi10.1177/1352458520981300-
dc.identifier.pmid33423618-
dc.identifier.isi000677275500001-
dc.identifier.eissn1477-0970-
local.provider.typeWeb of Science-
local.uhasselt.internationalyes-
item.contributorRoos, I-
item.contributorLeray, E-
item.contributorFrascoli, F-
item.contributorCasey, R-
item.contributorBrown, JWL-
item.contributorHorakova, D-
item.contributorHavrdova, EK-
item.contributorDebouverie, M-
item.contributorTrojano, M-
item.contributorPatti, F-
item.contributorIzquierdo, G-
item.contributorEichau, S-
item.contributorEdan, G-
item.contributorPrat, A-
item.contributorGirard, M-
item.contributorDuquette, P-
item.contributorOnofrj, M-
item.contributorLugaresi, A-
item.contributorGrammond, P-
item.contributorCiron, J-
item.contributorRuet, A-
item.contributorOzakbas, S-
item.contributorDe Seze, J-
item.contributorLouapre, C-
item.contributorZephir, H-
item.contributorSa, MJ-
item.contributorSola, P-
item.contributorFerraro, D-
item.contributorLabauge, P-
item.contributorDefer, G-
item.contributorBergamaschi, R-
item.contributorLebrun-Frenay, C-
item.contributorBoz, C-
item.contributorCartechini, E-
item.contributorMoreau, T-
item.contributorLaplaud, D-
item.contributorLechner-Scott, J-
item.contributorGrand'Maison, F-
item.contributorGerlach, O-
item.contributorTerzi, M-
item.contributorGranella, F-
item.contributorAlroughani, R-
item.contributorIuliano, G-
item.contributorVan Pesch, V-
item.contributorVAN WIJMEERSCH, Bart-
item.contributorLa Spitaleri, D-
item.contributorSoysal, A-
item.contributorBerger, E.-
item.contributorPrevost, J-
item.contributorAguera-Morales, E-
item.contributorMcCombe, P-
item.contributorTrivino, TC-
item.contributorClavelou, P-
item.contributorPelletier, J-
item.contributorTurkoglu, R-
item.contributorStankoff, B-
item.contributorGout, O-
item.contributorThouvenot, E-
item.contributorHeinzlef, O-
item.contributorSidhom, Y-
item.contributorGouider, R-
item.contributorCsepany, T-
item.contributorBourre, B-
item.contributorAl Khedr, A-
item.contributorCasez, O-
item.contributorCabre, P-
item.contributorMontcuquet, A-
item.contributorWahab, A-
item.contributorCamdessanche, JP-
item.contributorMaurousset, A-
item.contributorPatry, I-
item.contributorHankiewicz, K-
item.contributorPottier, C-
item.contributorMaubeuge, N-
item.contributorLabeyrie, C-
item.contributorNifle, C-
item.contributorColes, A-
item.contributorMalpas, CB-
item.contributorVukusic, S-
item.contributorButzkueven, H-
item.contributorKalincik, T-
item.validationecoom 2022-
item.fullcitationRoos, I; Leray, E; Frascoli, F; Casey, R; Brown, JWL; Horakova, D; Havrdova, EK; Debouverie, M; Trojano, M; Patti, F; Izquierdo, G; Eichau, S; Edan, G; Prat, A; Girard, M; Duquette, P; Onofrj, M; Lugaresi, A; Grammond, P; Ciron, J; Ruet, A; Ozakbas, S; De Seze, J; Louapre, C; Zephir, H; Sa, MJ; Sola, P; Ferraro, D; Labauge, P; Defer, G; Bergamaschi, R; Lebrun-Frenay, C; Boz, C; Cartechini, E; Moreau, T; Laplaud, D; Lechner-Scott, J; Grand'Maison, F; Gerlach, O; Terzi, M; Granella, F; Alroughani, R; Iuliano, G; Van Pesch, V; VAN WIJMEERSCH, Bart; La Spitaleri, D; Soysal, A; Berger, E.; Prevost, J; Aguera-Morales, E; McCombe, P; Trivino, TC; Clavelou, P; Pelletier, J; Turkoglu, R; Stankoff, B; Gout, O; Thouvenot, E; Heinzlef, O; Sidhom, Y; Gouider, R; Csepany, T; Bourre, B; Al Khedr, A; Casez, O; Cabre, P; Montcuquet, A; Wahab, A; Camdessanche, JP; Maurousset, A; Patry, I; Hankiewicz, K; Pottier, C; Maubeuge, N; Labeyrie, C; Nifle, C; Coles, A; Malpas, CB; Vukusic, S; Butzkueven, H & Kalincik, T (2021) Determinants of therapeutic lag in multiple sclerosis. In: Multiple sclerosis journal, experimental, translational and clinical, 27(12), p. 1838-1851.-
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item.fulltextWith Fulltext-
crisitem.journal.eissn2055-2173-
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