High-intensity interval training versus progressive high-intensity circuit resistance 1 training on endothelial function and cardiorespiratory fitness in heart failure: a 2 preliminary randomized controlled trial 3

Abstract

Introduction Exercise training is strongly recommended as a therapeutic approach to treat individuals with heart failure. High-intensity exercise training modalities still controversial in this population. The study aims to preliminary assess the consequences of high-intensity exercise training modalities, aerobic interval training (HIIT) and progressive high circuit-resistance training (CRT), on primarily endothelial function and cardiorespiratory fitness, and secondly on muscle strength and physical performance in heart failure patients.Methods This preliminary multicentric randomized controlled trial comprised 23 heart failure patients, aged 56 10 years old, mainly New York Heart Association classification I and II (%), hemodynamically stable, who compromise at least 36 exercise sessions of a randomly assigned intervention (HIIT, CRT or control group). Endothelial function, cardiopulmonary exercise testing, muscle strength and physical performance were completed at baseline and post-intervention.Results Although no effects on endothelial function; both HIIT and CRT modalities were able to produce a positive effect on <graphic id="pone.0257607.e001g" mimetype="image" position="anchor" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="info:doi/10.1371/journal.pone.0257607.e001" xlink:type="simple"></graphic>V<mml:mo></mml:mover>O2 peak (HIIT = +2.16.5, CRT = +3.0 +/- 4.2 and control group = -0.1 +/- 5.3 mL/kg/min, time*group p-value<0,05) and METs (HIIT = +0.6<plus/minus>1.8, CRT = +0.9 +/- 1.2 and control group = 0 +/- 1.6, time*group p-value<0,05). Only HIIT increased isokinetic torque peak (HIIT = +8.8<plus/minus>55.8, CRT = 0.0 +/- 60.7 and control group = 1.6 +/- 57.6 Nm) matched p-value<0,05. Regarding the physical performance, the CRT modality reduced chair stand test completion time (HIIT = -0.7<plus/minus>3.1, CRT = -3.3 +/- 3.2 and control group = -0.3 +/- 2.5 s, matched p-value<0,05 and HIIT improved global physical performance(time*group p<0,05).Conclusion This preliminary study trends to indicate for the first time that high-intensity interval training promotes a jointly superior effect compared to progressive high intensity circuit-resistance training by improving cardiorespiratory fitness, muscular strength, and physical performance. Further research with larger cohort is necessary.Clinical trial registration number ReBEC RBR-668c8v.