Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/35522
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dc.contributor.authorVAN DEN BERGH, Joop-
dc.contributor.authorSzulc, P-
dc.contributor.authorCheung, AM-
dc.contributor.authorBouxsein, M-
dc.contributor.authorEngelke, K-
dc.contributor.authorChapurlat, R-
dc.date.accessioned2021-10-14T09:01:14Z-
dc.date.available2021-10-14T09:01:14Z-
dc.date.issued2021-
dc.date.submitted2021-09-17T12:22:43Z-
dc.identifier.citationOsteoporosis international, 32 (8) , p. 1465 -1485-
dc.identifier.urihttp://hdl.handle.net/1942/35522-
dc.description.abstractHigh-resolution peripheral computed tomography (HR-pQCT) was developed to image bone microarchitecture in vivo at peripheral skeletal sites. Since the introduction of HR-pQCT in 2005, clinical research to gain insight into pathophysiology of skeletal fragility and to improve prediction of fractures has grown. Meanwhile, the second-generation HR-pQCT device has been introduced, allowing novel applications such as hand joint imaging, assessment of subchondral bone and cartilage thickness in the knee, and distal radius fracture healing. This article provides an overview of the current clinical applications and guidance on interpretation of results, as well as future directions. Specifically, we provide an overview of (1) the differences and reference data for HR-pQCT variables by age, sex, and race/ethnicity; (2) fracture risk prediction using HR-pQCT; (3) the ability to monitor response of anti-osteoporosis therapy with HR-pQCT; (4) the use of HR-pQCT in patients with metabolic bone disorders and diseases leading to secondary osteoporosis; and (5) novel applications of HR-pQCT imaging. Finally, we summarize the status of the application of HR-pQCT in clinical practice and discuss future directions. From the clinical perspective, there are both challenges and opportunities for more widespread use of HR-pQCT. Assessment of bone microarchitecture by HR-pQCT improves fracture prediction in mostly normal or osteopenic elderly subjects beyond DXA of the hip, but the added value is marginal. The prospects of HR-pQCT in clinical practice need further study with respect to medication effects, metabolic bone disorders, rare bone diseases, and other applications such as hand joint imaging and fracture healing. The mostly unexplored potential may be the differentiation of patients with only moderately low BMD but severe microstructural deterioration, which would have important implications for the decision on therapeutical interventions.-
dc.description.sponsorshipThese guidelines have been reviewed and endorsed by the Committee of Scientific Advisors of the International Osteoporosis Foundation, the American Society for Bone and Mineral Research, and the European Calcified Tissue Society-
dc.language.isoen-
dc.publisherSPRINGER LONDON LTD-
dc.rightsThe Author(s) 2021 This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.-
dc.subject.otherFracture risk prediction-
dc.subject.otherHigh-resolution peripheral quantitative computed tomography (HR-pQCT)-
dc.subject.otherMetabolic bone disorders-
dc.subject.otherOsteoporosis-
dc.subject.otherReference data-
dc.titleThe clinical application of high-resolution peripheral computed tomography (HR-pQCT) in adults: state of the art and future directions-
dc.typeJournal Contribution-
dc.identifier.epage1485-
dc.identifier.issue8-
dc.identifier.spage1465-
dc.identifier.volume32-
local.bibliographicCitation.jcatA1-
local.publisher.place236 GRAYS INN RD, 6TH FLOOR, LONDON WC1X 8HL, ENGLAND-
local.type.refereedRefereed-
local.type.specifiedArticle-
dc.identifier.doi10.1007/s00198-021-05999-z-
dc.identifier.isi000652919700002-
local.provider.typeWeb of Science-
local.uhasselt.internationalyes-
item.validationecoom 2022-
item.contributorVAN DEN BERGH, Joop-
item.contributorSzulc, P-
item.contributorCheung, AM-
item.contributorBouxsein, M-
item.contributorEngelke, K-
item.contributorChapurlat, R-
item.accessRightsOpen Access-
item.fullcitationVAN DEN BERGH, Joop; Szulc, P; Cheung, AM; Bouxsein, M; Engelke, K & Chapurlat, R (2021) The clinical application of high-resolution peripheral computed tomography (HR-pQCT) in adults: state of the art and future directions. In: Osteoporosis international, 32 (8) , p. 1465 -1485.-
item.fulltextWith Fulltext-
crisitem.journal.issn0937-941X-
crisitem.journal.eissn1433-2965-
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