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Title: | Fasting alters the gut microbiome reducing blood pressure and body weight in metabolic syndrome patients | Authors: | Maifeld, A Bartolomaeus, H Lober, U Avery, EG Steckhan, N Marko, L Wilck, N HAMAD, Ibrahim Susnjar, U Mahler, A Hohmann, C Chen, CY Cramer, H Dobos, G Lesker, TR Strowig, T Dechend, R Bzdok, D KLEINEWIETFELD, Markus Michalsen, A Muller, DN Forslund, SK |
Issue Date: | 2021 | Publisher: | NATURE RESEARCH | Source: | Nature communications, 12 (1) (Art N° 1970) | Abstract: | Periods of fasting and refeeding may reduce cardiometabolic risk elevated by Western diet. Here we show in the substudy of NCT02099968, investigating the clinical parameters, the immunome and gut microbiome exploratory endpoints, that in hypertensive metabolic syndrome patients, a 5-day fast followed by a modified Dietary Approach to Stop Hypertension diet reduces systolic blood pressure, need for antihypertensive medications, body-mass index at three months post intervention compared to a modified Dietary Approach to Stop Hypertension diet alone. Fasting alters the gut microbiome, impacting bacterial taxa and gene modules associated with short-chain fatty acid production. Cross-system analyses reveal a positive correlation of circulating mucosa-associated invariant T cells, non-classical monocytes and CD4(+) effector T cells with systolic blood pressure. Furthermore, regulatory T cells positively correlate with body-mass index and weight. Machine learning analysis of baseline immunome or microbiome data predicts sustained systolic blood pressure response within the fasting group, identifying CD8(+) effector T cells, Th17 cells and regulatory T cells or Desulfovibrionaceae, Hydrogenoanaerobacterium, Akkermansia, and Ruminococcaceae as important contributors to the model. Here we report that the high-resolution multi-omics data highlight fasting as a promising non-pharmacological intervention for the treatment of high blood pressure in metabolic syndrome patients. Nutritional modification including fasting has been shown to reduce cardiometabolic risk linked to western diet. Here the authors show implementation of fasting resulted in alterations to the intestinal microbiota, and circulating immune cells, improving blood pressure and body weight in patients with metabolic syndrome. | Keywords: | Aged;Akkermansia;Blood Pressure;Body Mass Index;Body Weight;Desulfovibrionaceae;Diet;Fasting;Feces;Female;Gastrointestinal Microbiome;Humans;Hypertension;Male;Metabolic Syndrome;Middle Aged;Ruminococcus;T-Lymphocyte Subsets | Document URI: | http://hdl.handle.net/1942/35533 | e-ISSN: | 2041-1723 | DOI: | 10.1038/s41467-021-22097-0 | ISI #: | 000637938900004 | Rights: | The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2022 |
Appears in Collections: | Research publications |
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s41467-021-22097-0.pdf | Published version | 3.19 MB | Adobe PDF | View/Open |
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