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http://hdl.handle.net/1942/3555
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DC Field | Value | Language |
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dc.contributor.author | MEDAER, Rob | - |
dc.contributor.author | STINISSEN, Piet | - |
dc.contributor.author | RAUS, Jef | - |
dc.contributor.author | ZHANG, JINGWU | - |
dc.contributor.author | TRUYEN, L | - |
dc.date.accessioned | 2007-11-29T08:13:43Z | - |
dc.date.available | 2007-11-29T08:13:43Z | - |
dc.date.issued | 1995 | - |
dc.identifier.citation | LANCET, 346(8978). p. 807-808 | - |
dc.identifier.issn | 0099-5355 | - |
dc.identifier.uri | http://hdl.handle.net/1942/3555 | - |
dc.description.abstract | In a pilot trial, eight patients with multiple sclerosis were matched to control patients and received T-cell vaccination with irradiated T cells reactive to myelin basic protein (MBP) to deplete circulating MBP-reactive T cells. In the 2 years before and after vaccination, exacerbations decreased in five vaccinated patients (numbers 1, 2, 6-8) with relapsing-remitting disease from sixteen to three, respectively, and from twelve to ten in their matched controls. Magnetic resonance imaging showed a mean 8.0% increase in brain lesion size in the vaccinated patients compared with a 39.5% increase in the controls. Lesions and/or relapses worsened in three cases after Vaccination in association with reappearance of circulating MBP-reactive T cells. | - |
dc.language.iso | en | - |
dc.publisher | LANCET LTD | - |
dc.title | DEPLETION OF MYELIN-BASIC-PROTEIN AUTOREACTIVE T-CELLS BY T-CELL VACCINATION - PILOT TRIAL IN MULTIPLE-SCLEROSIS | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 808 | - |
dc.identifier.issue | 8978 | - |
dc.identifier.spage | 807 | - |
dc.identifier.volume | 346 | - |
local.format.pages | 2 | - |
dc.description.notes | FREE UNIV AMSTERDAM,ACAD HOSP,DEPT DIAGNOST RADIOL,AMSTERDAM,NETHERLANDS. CLIN DE MICK,MULTIPLE SCLEROSIS REHABIL UNIT,BRASSCHAAT,BELGIUM.MEDAER, R, LIMBURGS UNIV CENTRUM,DR L WILLEMS INST,MULTIPLE SCLEROSIS RES & IMMUNOL UNIT,B-3590 DLEPENBEEK,BELGIUM. | - |
local.type.refereed | Refereed | - |
local.type.specified | Note | - |
dc.bibliographicCitation.oldjcat | A1 | - |
dc.identifier.doi | 10.1016/S0140-6736(95)91622-9 | - |
dc.identifier.isi | A1995RW25800013 | - |
item.fulltext | No Fulltext | - |
item.fullcitation | MEDAER, Rob; STINISSEN, Piet; RAUS, Jef; ZHANG, JINGWU & TRUYEN, L (1995) DEPLETION OF MYELIN-BASIC-PROTEIN AUTOREACTIVE T-CELLS BY T-CELL VACCINATION - PILOT TRIAL IN MULTIPLE-SCLEROSIS. In: LANCET, 346(8978). p. 807-808. | - |
item.accessRights | Closed Access | - |
item.contributor | MEDAER, Rob | - |
item.contributor | STINISSEN, Piet | - |
item.contributor | RAUS, Jef | - |
item.contributor | ZHANG, JINGWU | - |
item.contributor | TRUYEN, L | - |
Appears in Collections: | Research publications |
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