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Title: | Heart failure in COVID-19: the multicentre, multinational PCHF-COVICAV registry | Authors: | Sokolski, Mateusz Trenson, Sander Sokolska, Justyna M. D'Amario, Domenico Meyer, Philippe Poku, Nana K. Biering-Sorensen, Tor Lassen, Mats C. Hojbjerg Skaarup, Kristoffer G. Barge-Caballero, Eduardo Pouleur, Anne-Catherine Stolfo, Davide Sinagra, Gianfranco Ablasser, Klemens Muster, Viktoria Rainer, Peter P. Wallner, Markus Chiodini, Alessandra Heiniger, Pascal S. Mikulicic, Fran Schwaiger, Judith Winnik, Stephan Cakmak, Huseyin A. Gaudenzi, Margherita Mapelli, Massimo Mattavelli, Irene Paul, Matthias Cabac-Pogorevici, Irina Bouleti, Claire Lilliu, Marzia Minoia, Chiara DAUW, Jeroen Costa, Jerome Celik, Ahmet Mewton, Nathan Montenegro, Carlos E. L. Matsue, Yuya Loncar, Goran Marchel, Michal Bechlioulis, Aris Michalis, Lampros Dorr, Marcus Prihadi, Edgard Schoenrath, Felix Messroghli, Daniel R. MULLENS, Wilfried Lund, Lars H. Rosano, Giuseppe M. C. Ponikowski, Piotr Ruschitzka, Frank Flammer, Andreas J. |
Issue Date: | 2021 | Publisher: | WILEY PERIODICALS, INC | Source: | ESC Heart Failure, | Abstract: | Aims: We assessed the outcome of hospitalized coronavirus disease 2019 (COVID-19) patients with heart failure (HF) compared with patients with other cardiovascular disease and/or risk factors (arterial hypertension, diabetes, or dyslipidaemia). We further wanted to determine the incidence of HF events and its consequences in these patient populations. Methods and results: International retrospective Postgraduate Course in Heart Failure registry for patients hospitalized with COVID-19 and CArdioVascular disease and/or risk factors (arterial hypertension, diabetes, or dyslipidaemia) was performed in 28 centres from 15 countries (PCHF-COVICAV). The primary endpoint was in-hospital mortality. Of 1974 patients hospitalized with COVID-19, 1282 had cardiovascular disease and/or risk factors (median age: 72 [interquartile range: 62-81] years, 58% male), with HF being present in 256 [20%] patients. Overall in-hospital mortality was 25% (n = 323/1282 deaths). In-hospital mortality was higher in patients with a history of HF (36%, n = 92) compared with non-HF patients (23%, n = 231, odds ratio [OR] 1.93 [95% confidence interval: 1.44-2.59], P < 0.001). After adjusting, HF remained associated with in-hospital mortality (OR 1.45 [95% confidence interval: 1.01-2.06], P = 0.041). Importantly, 186 of 1282 [15%] patients had an acute HF event during hospitalization (76 [40%] with de novo HF), which was associated with higher in-hospital mortality (89 [48%] vs. 220 [23%]) than in patients without HF event (OR 3.10 [2.24-4.29], P < 0.001). Conclusions: Hospitalized COVID-19 patients with HF are at increased risk for in-hospital death. In-hospital worsening of HF or acute HF de novo are common and associated with a further increase in in-hospital mortality. | Notes: | Flammer, AJ (corresponding author), Univ Hosp Zurich, Univ Heart Ctr, Dept Cardiol, Raemistr 100, CH-8091 Zurich, Switzerland. andreas.flammer@usz.ch |
Keywords: | COVID-19; SARS-CoV2; Heart failure; Cardiovascular disease; Risk factors | Document URI: | http://hdl.handle.net/1942/35750 | ISSN: | 2055-5822 | e-ISSN: | 2055-5822 | DOI: | 10.1002/ehf2.13549 | ISI #: | 000696508600001 | Rights: | 2021 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium,provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2022 |
Appears in Collections: | Research publications |
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ESC Heart Failure - 2021 - Sokolski - Heart failure in COVID‐19 the multicentre multinational PCHF‐COVICAV registry.pdf Restricted Access | Published version | 2.46 MB | Adobe PDF | View/Open Request a copy |
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