Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/35790
Full metadata record
DC FieldValueLanguage
dc.contributor.authorGoërtz, Yvonne-
dc.contributor.authorBraamse, Annemarie-
dc.contributor.authorSPRUIT, Martijn A.-
dc.contributor.authorJanssen, Daisy-
dc.contributor.authorEbadi, Zjala-
dc.contributor.authorVAN HERCK, Maarten-
dc.contributor.authorBURTIN, Chris-
dc.contributor.authorPeters, Jeannette-
dc.contributor.authorSprangers, Mirjam-
dc.contributor.authorLamers, Femke-
dc.contributor.authorTwisk, Jos-
dc.contributor.authorThong, Melissa-
dc.contributor.authorVercoulen, Jan-
dc.contributor.authorGeerlings, Suzanne-
dc.contributor.authorVaes, Anouk-
dc.contributor.authorBeijers, Rosanne-
dc.contributor.authorVAN BEERS, Martijn-
dc.contributor.authorSchols, Annemie-
dc.contributor.authorRosmalen, Judith-
dc.contributor.authorKnoop, Hans-
dc.date.accessioned2021-11-09T13:55:19Z-
dc.date.available2021-11-09T13:55:19Z-
dc.date.issued2021-
dc.date.submitted2021-10-29T07:14:02Z-
dc.identifier.citationScientific reports (Nature Publishing Group), 11 (1) (Art N° 20977)-
dc.identifier.urihttp://hdl.handle.net/1942/35790-
dc.description.abstract(1) To evaluate the prevalence of severe and chronic fatigue in subjects with and without chronic disease; (2) to assess to which extent multi-morbidity contributes to severe and chronic fatigue; and (3) to identify predisposing and associated factors for severe and chronic fatigue and whether these are disease-specific, trans-diagnostic, or generic. The Dutch Lifelines cohort was used, including 78,363 subjects with (n = 31,039, 53 ± 12 years, 33% male) and without (n = 47,324, 48 ± 12 years, 46% male) ≥ 1 of 23 chronic diseases. Fatigue was assessed with the Checklist Individual Strength-Fatigue. Compared to participants without a chronic disease, a higher proportion of participants with ≥ 1 chronic disease were severely (23% versus 15%, p < 0.001) and chronically (17% versus 10%, p < 0.001) fatigued. The odds of having severe fatigue (OR [95% CI]) increased from 1.6 [1.5-1.7] with one chronic disease to 5.5 [4.5-6.7] with four chronic diseases; for chronic fatigue from 1.5 [1.5-1.6] to 4.9 [3.9-6.1]. Multiple trans-diagnostic predisposing and associated factors of fatigue were found, explaining 26% of variance in fatigue in chronic disease. Severe and chronic fatigue are highly prevalent in chronic diseases. Multi-morbidity increases the odds of having severe and chronic fatigue. Several trans-diagnostic factors were associated with fatigue, providing a rationale for a trans-diagnostic approach.-
dc.language.isoen-
dc.publisherNATURE PORTFOLIO-
dc.rightsOpen Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http:// creat iveco mmons. org/ licen ses/ by/4. 0/.-
dc.titleFatigue in patients with chronic disease: results from the population-based Lifelines Cohort Study-
dc.typeJournal Contribution-
dc.identifier.issue1-
dc.identifier.volume11-
local.bibliographicCitation.jcatA1-
local.publisher.placeHEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY-
dc.relation.references1. Ream, E. & Richardson, A. Fatigue in patients with cancer and chronic obstructive airways disease: A phenomenological enquiry. Int. J. Nurs. Stud. 34(1), 44–53 (1997). 2. Korenromp, I. H., Meeus, M. & Bleijenberg, G. Dutch language area definition of chronic fatigue. Ned. Tijdschr. Geneeskd. 156(16), A4403 (2012). 3. Alves, G., Wentzel-Larsen, T. & Larsen, J. P. Is fatigue an independent and persistent symptom in patients with Parkinson disease?. Neurology 63(10), 1908–1911 (2004). 4. Evangelista, L. S. et al. Correlates of fatigue in patients with heart failure. Prog. Cardiovasc. Nurs. 23(1), 12–17 (2008). 5. Goertz, Y. M. J. et al. Fatigue is highly prevalent in patients with COPD and correlates poorly with the degree of airflow limitation. Therap. Adv. Respir. Dis. 13, 1753466619878128 (2019). 6. Goedendorp, M. M. et al. Chronic fatigue in type 1 diabetes: Highly prevalent but not explained by hyperglycemia or glucose variability. Diabetes Care 37(1), 73–80 (2014). 7. van Hoogmoed, D., Fransen, J., Bleijenberg, G. & van Riel, P. Physical and psychosocial correlates of severe fatigue in rheumatoid arthritis. Rheumatology (Oxford) 49(7), 1294–1302 (2010). 8. Jelsness-Jørgensen, L. P., Bernklev, T., Henriksen, M., Torp, R. & Moum, B. A. Chronic fatigue is more prevalent in patients with inflammatory bowel disease than in healthy controls. Inflamm. Bowel Dis. 17(7), 1564–1572 (2011). 9. Jaime-Lara, R. B., Koons, B. C., Matura, L. A., Hodgson, N. A. & Riegel, B. A qualitative metasynthesis of the experience of fatigue across five chronic conditions. J Pain Sympt. Manage. 2, 25 (2019). 10. Gelauff, J. M. et al. Fatigue, not self-rated motor symptom severity, affects quality of life in functional motor disorders. J. Neurol. 265(8), 1803–1809 (2018). 11. Marengoni, A., Rizzuto, D., Wang, H. X., Winblad, B. & Fratiglioni, L. Patterns of chronic multimorbidity in the elderly population. J. Am. Geriatr. Soc. 57(2), 225–230 (2009). 12. Pefoyo, A. J. et al. The increasing burden and complexity of multimorbidity. BMC Public Health 15, 415 (2015). 13. Belza, B. L. Comparison of self-reported fatigue in rheumatoid arthritis and controls. J. Rheumatol. 22(4), 639–643 (1995). 14. Krupp, L. B., Alvarez, L. A., LaRocca, N. G. & Scheinberg, L. C. Fatigue in multiple sclerosis. Arch. Neurol. 45(4), 435–437 (1988). 15. Franssen, P. M., Bultmann, U., Kant, I. & van Amelsvoort, L. G. The association between chronic diseases and fatigue in the working population. J. Psychosom. Res. 54(4), 339–344 (2003). 16. Menting, J. et al. Is fatigue a disease-specific or generic symptom in chronic medical conditions?. Health Psychol. 37(6), 530–543 (2018). 17. Van Herck, M. et al. Fatigue is highly prevalent in patients with asthma and contributes to the burden of disease. J. Clin. Med. 7, 12 (2018). 18. Krupp, L. B., LaRocca, N. G., Muir, J. & Steinberg, A. D. A study of fatigue in systemic lupus erythematosus. J. Rheumatol. 17(11), 1450–1452 (1990). 19. Huyser, B. A. et al. Predictors of subjective fatigue among individuals with rheumatoid arthritis. Arthritis Rheum. 41(12), 2230–2237 (1998). 20. Bloem, A. E. M. et al. Severe fatigue is highly prevalent in patients with IPF or sarcoidosis. J. Clin. Med. 9, 4 (2020). 21. Mollaoglu, M. & Ustun, E. Fatigue in multiple sclerosis patients. J. Clin. Nurs. 18(9), 1231–1238 (2009). 22. Lerdal, A., Celius, E. G. & Moum, T. Fatigue and its association with sociodemographic variables among multiple sclerosis patients. Multiple Scler. (Houndmills, Basingstoke, England). 9(5), 509–514 (2003). 23. Mollaoglu, M. Fatigue in people undergoing hemodialysis. Dialysis Transplant. 38(6), 216–220 (2009). 24. Merkelbach, S., Konig, J. & Sittinger, H. Personality traits in multiple sclerosis (MS) patients with and without fatigue experience. Acta Neurol. Scand. 107(3), 195–201 (2003). 25. Penner, I. K. et al. Fatigue in multiple sclerosis: Relation to depression, physical impairment, personality and action control. Multiple Scler. (Houndmills, Basingstoke, England). 13(9), 1161–1167 (2007). 26. Schreiber, H., Lang, M., Kiltz, K. & Lang, C. Is personality profile a relevant determinant of fatigue in multiple sclerosis?. Front. Neurol. 6, 2 (2015). 27. Falk, K., Patel, H., Swedberg, K. & Ekman, I. Fatigue in patients with chronic heart failure—a burden associated with emotional and symptom distress. Eur. J. Cardiovas. Nurs. 8(2), 91–96 (2009). 28. Jump, R. L. et al. Fatigue in systemic lupus erythematosus: Contributions of disease activity, pain, depression, and perceived social support. J. Rheumatol. 32(9), 1699–1705 (2005). 29. Kroencke, D. C., Lynch, S. G. & Denney, D. R. Fatigue in multiple sclerosis: Relationship to depression, disability, and disease pattern. Multiple Scler. (Houndmills, Basingstoke, Engl.) 6(2), 131–136 (2000). 30. Kentson, M. et al. Factors associated with experience of fatigue, and functional limitations due to fatigue in patients with stable COPD. Ther. Adv. Respir. Dis. 10(5), 410–424 (2016). 31. Andersson, M., Stridsman, C., Ronmark, E., Lindberg, A. & Emtner, M. Physical activity and fatigue in chronic obstructive pulmonary disease—a population based study. Respir. Med. 109(8), 1048–1057 (2015). 32. Da Costa, D. et al. Dimensions of fatigue in systemic lupus erythematosus: Relationship to disease status and behavioral and psychosocial factors. J. Rheumatol. 33(7), 1282–1288 (2006). 33. O’Sullivan, D. & McCarthy, G. An exploration of the relationship between fatigue and physical functioning in patients with end stage renal disease receiving haemodialysis. J. Clin. Nurs. 16(11c), 276–284 (2007). 34. Williams, B. A. The clinical epidemiology of fatigue in newly diagnosed heart failure. BMC Cardiovasc. Disord. 17(1), 122 (2017). 35. Erickson, S. R., Williams, B. C. & Gruppen, L. D. Perceived symptoms and health-related quality of life reported by uncomplicated hypertensive patients compared to normal controls. J. Hum. Hypertens. 15(8), 539–548 (2001). 36. Harbison, J. A., Walsh, S. & Kenny, R. A. Hypertension and daytime hypotension found on ambulatory blood pressure is associated with fatigue following stroke and TIA. QJM Mon. J. Assoc. Physicians 102(2), 109–115 (2009). 37. Belza, B. L., Henke, C. J., Yelin, E. H., Epstein, W. V. & Gilliss, C. L. Correlates of fatigue in older adults with rheumatoid arthritis. Nurs. Res. 42(2), 93–99 (1993). 38. Wolfe, F., Hawley, D. J. & Wilson, K. The prevalence and meaning of fatigue in rheumatic disease. J. Rheumatol. 23(8), 1407–1417 (1996). 39. Kahraman, T., Ozdogar, A. T., Abasiyanik, Z. & Ozakbas, S. Associations between smoking and walking, fatigue, depression, and health-related quality of life in persons with multiple sclerosis. Acta Neurol. Belg. 20, 20 (2020). 40. Stridsman, C., Mullerova, H., Skar, L. & Lindberg, A. Fatigue in COPD and the impact of respiratory symptoms and heart disease—a population-based study. COPD 10(2), 125–132 (2013). 41. Hopman, P., Schellevis, F. G. & Rijken, M. Health-related needs of people with multiple chronic diseases: Differences and underlying factors. Quali. Life Res. 25(3), 651–660 (2016). 42. Stolk, R. P. et al. Universal risk factors for multifactorial diseases: LifeLines: A three-generation population-based study. Eur. J. Epidemiol. 23(1), 67–74 (2008). 43. Scholtens, S. et al. Cohort Profile: LifeLines, a three-generation cohort study and biobank. Int. J. Epidemiol. 44(4), 1172–1180 (2015). 44. Klijs, B. et al. Representativeness of the LifeLines Cohort Study. PloS One 10(9), e0137203 (2015). 45. Vercoulen, J. H. et al. Dimensional assessment of chronic fatigue syndrome. J. Psychosom. Res. 38(5), 383–392 (1994). 46. Worm-Smeitink, M. et al. The assessment of fatigue: Psychometric qualities and norms for the Checklist individual strength. J. Psychosom. Res. 98, 40–46 (2017). 47. Beurskens, A. J. et al. Fatigue among working people: Validity of a questionnaire measure. Occup. Environ. Med. 57(5), 353–357 (2000). 48. Bultmann, U. et al. Measurement of prolonged fatigue in the working population: Determination of a cutoff point for the checklist individual strength. J. Occup. Health Psychol. 5(4), 411–416 (2000). 49. Peters, J. B. et al. Course of normal and abnormal fatigue in patients with chronic obstructive pulmonary disease, and its relationship with domains of health status. Patient Educ. Couns. 85(2), 281–285 (2011). 50. Repping-Wuts, H., Fransen, J., van Achterberg, T., Bleijenberg, G. & van Riel, P. Persistent severe fatigue in patients with rheumatoid arthritis. J. Clin. Nurs. 16(11c), 377–383 (2007). 51. Goodman, R. A., Posner, S. F., Huang, E. S., Parekh, A. K. & Koh, H. K. Defining and measuring chronic conditions: Imperatives for research, policy, program, and practice. Prev. Chronic Dis. 10, E66 (2013). 52. Janssen, D. J. A. et al. Clustering of 27,525,663 death records from the United States based on health conditions associated with death: An example of big health data exploration. J. Clin. Med. 8, 7 (2019). 53. Costa, P. & McCrae, R. Revised NEO Personality Inventory (NEO PI-R) and the Five Factor Inventory (NEO-FFI): Professional manual. FL: Odessa; 1992. 54. Netherlands, S. International definition of unemployment. https://www.cbs.nl/en-gb/news/2007/29/dutch-unemployment-ratelowest-in-eu/international-definition-of-unemployment. 55. Wendel-Vos, G. C., Schuit, A. J., Saris, W. H. & Kromhout, D. Reproducibility and relative validity of the short questionnaire to assess health-enhancing physical activity. J. Clin. Epidemiol. 56(12), 1163–1169 (2003). 56. Sheehan, D. V. et al. The Mini-International Neuropsychiatric Interview (MINI): The development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J. Clin. Psychiatry 59, 22–33 (1998). 57. Abad-Díez, J. M. et al. Age and gender differences in the prevalence and patterns of multimorbidity in the older population. BMC Geriatr. 14, 75 (2014). 58. Galligan, N. G., Hevey, D., Coen, R. F. & Harbison, J. A. Clarifying the associations between anxiety, depression and fatigue following stroke. J. Health Psychol. 21(12), 2863–2871 (2016). 59. Delva, I., Lytvynenko, N. & Delva, M. Factors associated with post-stroke fatigue within the first 3 month after stroke. Georgian Med. News 267, 38–42 (2017). 60. Warren, R. E., Deary, I. J. & Frier, B. M. The symptoms of hyperglycaemia in people with insulin-treated diabetes: Classification using principal components analysis. Diabetes Metab. Res. Rev. 19(5), 408–414 (2003). 61. Tang, W. R., Yu, C. Y. & Yeh, S. J. Fatigue and its related factors in patients with chronic heart failure. J. Clin. Nurs. 19(1–2), 69–78 (2010). 62. Liu, H. E. Fatigue and associated factors in hemodialysis patients in Taiwan. Res. Nurs. Health 29(1), 40–50 (2006). 63. Li, L. S. K., Butler, S., Goldstein, R. & Brooks, D. Comparing the impact of different exercise interventions on fatigue in individuals with COPD: A systematic review and meta-analysis. Chron. Respir. Dis. 16, 1479973119894855 (2019). 64. Asano, M. & Finlayson, M. L. Meta-analysis of three different types of fatigue management interventions for people with multiple sclerosis: Exercise, education, and medication. Multiple Scler. Int. 2014, 798285 (2014). 65. Zhao, Q. G. et al. Exercise interventions on patients with end-stage renal disease: A systematic review. Clin. Rehabil. 33(2), 147–156 (2019). 66. Heine, M., van de Port, I., Rietberg, M. B., van Wegen, E. E. & Kwakkel, G. Exercise therapy for fatigue in multiple sclerosis. Cochrane Database Syst. Rev. 9, Cd009956 (2015). 67. Prothero, L., Barley, E., Galloway, J., Georgopoulou, S. & Sturt, J. The evidence base for psychological interventions for rheumatoid arthritis: A systematic review of reviews. Int. J. Nurs. Stud. 82, 20–29 (2018). 68. Menting, J. et al. Web-based cognitive behavioural therapy blended with face-to-face sessions for chronic fatigue in type 1 diabetes: A multicentre randomised controlled trial. Lancet Diabetes Endocrinol. 5(6), 448–456 (2017). 69. Matura, L. A., Malone, S., Jaime-Lara, R. & Riegel, B. A Systematic review of biological mechanisms of fatigue in chronic illness. Biol. Res. Nurs. 20(4), 410–421 (2018).-
local.type.refereedRefereed-
local.type.specifiedArticle-
local.bibliographicCitation.artnr20977-
dc.identifier.doi10.1038/s41598-021-00337-z-
dc.identifier.isiWOS:000711121600074-
local.provider.typePdf-
local.uhasselt.uhpubyes-
local.dataset.citationWe are not permitted to share individual data from the Dutch Lifelines study. Information on applying for access to the Dutch Lifelines data is available at https://www.lifelines.nl/researcher/how-to-apply.-
local.uhasselt.internationalyes-
item.contributorGoërtz, Yvonne-
item.contributorBraamse, Annemarie-
item.contributorSPRUIT, Martijn A.-
item.contributorJanssen, Daisy-
item.contributorEbadi, Zjala-
item.contributorVAN HERCK, Maarten-
item.contributorBURTIN, Chris-
item.contributorPeters, Jeannette-
item.contributorSprangers, Mirjam-
item.contributorLamers, Femke-
item.contributorTwisk, Jos-
item.contributorThong, Melissa-
item.contributorVercoulen, Jan-
item.contributorGeerlings, Suzanne-
item.contributorVaes, Anouk-
item.contributorBeijers, Rosanne-
item.contributorVAN BEERS, Martijn-
item.contributorSchols, Annemie-
item.contributorRosmalen, Judith-
item.contributorKnoop, Hans-
item.accessRightsOpen Access-
item.fulltextWith Fulltext-
item.fullcitationGoërtz, Yvonne; Braamse, Annemarie; SPRUIT, Martijn A.; Janssen, Daisy; Ebadi, Zjala; VAN HERCK, Maarten; BURTIN, Chris; Peters, Jeannette; Sprangers, Mirjam; Lamers, Femke; Twisk, Jos; Thong, Melissa; Vercoulen, Jan; Geerlings, Suzanne; Vaes, Anouk; Beijers, Rosanne; VAN BEERS, Martijn; Schols, Annemie; Rosmalen, Judith & Knoop, Hans (2021) Fatigue in patients with chronic disease: results from the population-based Lifelines Cohort Study. In: Scientific reports (Nature Publishing Group), 11 (1) (Art N° 20977).-
item.validationecoom 2022-
crisitem.journal.issn2045-2322-
crisitem.journal.eissn2045-2322-
Appears in Collections:Research publications
Files in This Item:
File Description SizeFormat 
Goërtz et al 2021 - Scientific reports - Fatigue in Lifelines cohort.pdfPublished version1.3 MBAdobe PDFView/Open
Show simple item record

WEB OF SCIENCETM
Citations

39
checked on May 16, 2024

Page view(s)

40
checked on Aug 20, 2022

Download(s)

12
checked on Aug 20, 2022

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.