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http://hdl.handle.net/1942/35829
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DC Field | Value | Language |
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dc.contributor.author | Kellens, S | - |
dc.contributor.author | VERBRUGGE, Frederik | - |
dc.contributor.author | Vanmechelen, M | - |
dc.contributor.author | GRIETEN, Lars | - |
dc.contributor.author | VAN LIERDE, Johan | - |
dc.contributor.author | DENS, Jo | - |
dc.contributor.author | VROLIX, Mathias | - |
dc.contributor.author | VANDERVOORT, Pieter | - |
dc.date.accessioned | 2021-11-17T10:51:06Z | - |
dc.date.available | 2021-11-17T10:51:06Z | - |
dc.date.issued | 2016 | - |
dc.date.submitted | 2021-11-17T10:43:15Z | - |
dc.identifier.citation | European heart journal. Acute cardiovascular care (Print), 5 (2) , p. 177 -184 | - |
dc.identifier.uri | http://hdl.handle.net/1942/35829 | - |
dc.description.abstract | Background: High-sensitivity cardiac troponin testing is used to detect myocardial damage in patients with acute chest pain. Heart-type fatty acid binding protein (H-FABP) may be an alternative, available as point-of-care test.Methods: Patients (n=203) referred by general practitioners for suspected acute coronary syndrome or presenting with typical chest pain and one major cardiovascular risk factor at the emergency department were prospectively included in a single-centre cohort study. High-sensitivity cardiac troponin T (hs-TnT) and point-of-care H-FABP testing were concomitantly performed at admission and after 6h.Results: Maximal hs-TnT levels above the 99th percentile were observed in 152 patients (75%) with 127 (63%) fulfilling criteria for myocardial infarction. Upon admission, hs-TnT and H-FABP were associated with an area under the curve (95% CI) of 0.83 (0.77-0.89) and 0.79 (0.73-0.85), respectively, to predict myocardial infarction, which increased to 0.93 (0.90-0.97) and 0.88 (0.84-0.93), respectively, after 6h. The diagnostic accuracy for non-ST-segment elevation myocardial infarction was somewhat lower with an area under the curve (95% CI) of 0.80 (0.72-0.87), 0.90 (0.84-0.96), 0.73 (0.64-0.81) and 0.77 (0.67-0.86), respectively. When assessment was performed within 3h of chest pain onset, diagnostic accuracy of H-FABP versus hs-TnT was similar. Each standard deviation increase in admission H-FABP was associated with a 68% relative risk increase of all-cause mortality (p-value=0.027) during 666155 days of follow-up.Conclusions: Point-of-care H-FABP testing has lower diagnostic accuracy compared with hs-TnT assessment in patients with high pre-test acute coronary syndrome probability, but might be of interest when assessment is possible early after chest pain onset. | - |
dc.description.sponsorship | This work was supported by FABPulous BV (Maastricht, the Netherlands). FV is supported by a PhD fellowship of the Research Foundation – Flanders (FWO, 11L8214N). FV, LG, JD and PV are researchers for the Limburg Clinical Research Program (LCRP) UHasselt-ZOL-Jessa, supported by the foundation Limburg Sterk Merk (LSM), Hasselt University, Ziekenhuis OostLimburg and Jessa Hospital. Acknowledgements This study was commissioned by FABPulous BV (Maastricht, the Netherlands), who provided the point-of-care H-FABP tests. The company was not involved in the data collection, analysis or writing of the manuscript, but had the opportunity to review the final version before submission and make additional recommendations. All authors had full access to the data and contributed to the writing of the manuscript. Together, they take responsibility for the integrity of the data and agree to the report as written. SK and FHV have contributed equally to this manuscript. | - |
dc.language.iso | en | - |
dc.publisher | SAGE PUBLICATIONS LTD | - |
dc.rights | © The European Society of Cardiology 2015 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav | - |
dc.subject.other | Acute coronary syndrome | - |
dc.subject.other | FABP3 protein | - |
dc.subject.other | myocardial infarction | - |
dc.subject.other | prognosis | - |
dc.title | Point-of-care heart-type fatty acid binding protein versus high-sensitivity troponin T testing in emergency patients at high risk for acute coronary syndrome | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 184 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 177 | - |
dc.identifier.volume | 5 | - |
local.bibliographicCitation.jcat | A1 | - |
local.publisher.place | 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1177/2048872615570221 | - |
dc.identifier.isi | 000371314300011 | - |
local.provider.type | Web of Science | - |
local.uhasselt.international | no | - |
item.fulltext | With Fulltext | - |
item.contributor | Kellens, S | - |
item.contributor | VERBRUGGE, Frederik | - |
item.contributor | Vanmechelen, M | - |
item.contributor | GRIETEN, Lars | - |
item.contributor | VAN LIERDE, Johan | - |
item.contributor | DENS, Jo | - |
item.contributor | VROLIX, Mathias | - |
item.contributor | VANDERVOORT, Pieter | - |
item.accessRights | Restricted Access | - |
item.validation | ecoom 2021 | - |
item.fullcitation | Kellens, S; VERBRUGGE, Frederik; Vanmechelen, M; GRIETEN, Lars; VAN LIERDE, Johan; DENS, Jo; VROLIX, Mathias & VANDERVOORT, Pieter (2016) Point-of-care heart-type fatty acid binding protein versus high-sensitivity troponin T testing in emergency patients at high risk for acute coronary syndrome. In: European heart journal. Acute cardiovascular care (Print), 5 (2) , p. 177 -184. | - |
crisitem.journal.issn | 2048-8726 | - |
crisitem.journal.eissn | 2048-8734 | - |
Appears in Collections: | Research publications |
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ehjacc0177.pdf Restricted Access | Published version | 807.29 kB | Adobe PDF | View/Open Request a copy |
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