Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/35846
Title: | Maternal Vitamin D and Newborn Telomere Length | Authors: | Daneels, L MARTENS, Dries Arredouani, S Billen, J Koppen, G Devlieger, R NAWROT, Tim Ghosh, M Godderis, L PAUWELS, Sara |
Issue Date: | 2021 | Publisher: | MDPI | Source: | Nutrients, 13 (6) (Art N° 2012) | Abstract: | Nutrition is important during pregnancy for offspring health. Gestational vitamin D intake may prevent several adverse outcomes and might have an influence on offspring telomere length (TL). In this study, we want to assess the association between maternal vitamin D intake during pregnancy and newborn TL, as reflected by cord blood TL. We studied mother-child pairs enrolled in the Maternal Nutrition and Offspring's Epigenome (MANOE) cohort, Leuven, Belgium. To calculate the dietary vitamin D intake, 108 women were asked to keep track of their diet using the seven-day estimated diet record (EDR) method. TL was assessed in 108 cord blood using a quantitative real-time PCR method. In each trimester of pregnancy, maternal serum 25-hydroxyvitamin D (25-OHD) concentration was measured. We observed a positive association (beta = 0.009, p-value = 0.036) between newborn average relative TL and maternal vitamin D intake (diet + supplement) during the first trimester. In contrast, we found no association between average relative TL of the newborn and mean maternal serum 25-OHD concentrations during pregnancy. To conclude, vitamin D intake (diet + supplements), specifically during the first trimester of pregnancy, is an important factor associated with TL at birth. | Keywords: | vitamin D;telomere length;pregnancy;newborn | Document URI: | http://hdl.handle.net/1942/35846 | e-ISSN: | 2072-6643 | DOI: | 10.3390/nu13062012 | ISI #: | 000666559900001 | Rights: | 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2022 |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Maternal Vitamin D and Newborn Telomere Length.pdf | Published version | 479.07 kB | Adobe PDF | View/Open |
WEB OF SCIENCETM
Citations
7
checked on Apr 14, 2024
Page view(s)
52
checked on Sep 7, 2022
Download(s)
20
checked on Sep 7, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.