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http://hdl.handle.net/1942/35860| Title: | Characterization of Gold Nanorods Conjugated with Synthetic Glycopolymers Using an Analytical Approach Based on spICP-SFMS and EAF4-MALS | Authors: | Velimirovic, Milica PANCARO, Alessia Mildner, Robert Georgiou, Panagiotis G. Tirez, Kristof Nelissen, Inge Johann, Christoph Gibson, Matthew I. Vanhaecke, Frank |
Issue Date: | 2021 | Publisher: | MDPI | Source: | NANOMATERIALS, 11 (10) , p. 2720 (Art N° 2720) | Abstract: | A new comprehensive analytical approach based on single-particle inductively coupled plasma-sector field mass spectrometry (spICP-SFMS) and electrical asymmetric-flow field-flow-fractionation combined with multi-angle light scattering detection (EAF4-MALS) has been examined for the characterization of galactosamine-terminated poly(N-hydroxyethyl acrylamide)-coated gold nanorods (GNRs) in two different degrees of polymerization (DP) by tuning the feed ratio (short: DP 35; long: DP 60). spICP-SFMS provided information on the particle number concentration, size and size distribution of the GNRs, and was found to be useful as an orthogonal method for fast characterization of GNRs. Glycoconjugated GNRs were separated and characterized via EAF4-MALS in terms of their size and charge and compared to the bare GNRs. In contrast to spICP-SFMS, EAF4-MALS was also able of providing an estimate of the thickness of the glycopolymer coating on the GNRs surface.</p> | Notes: | Velimirovic, M (corresponding author), Univ Ghent, Atom & Mass Spectrometry A&MS Res Grp, Dept Chem, Campus Sterre,Krijgslaan 281-S12, B-9000 Ghent, Belgium.; Velimirovic, M (corresponding author), Flemish Inst Technol Res VITO, Boeretang 200, B-2400 Mol, Belgium. milica.velimirovic@vito.be; alessia.pancaro@vito.be; Robert.Mildner@wyatt.eu; P.Georgiou@warwick.ac.uk; kristof.tirez@vito.be; inge.nelissen@vito.be; cjohann@wyatt.eu; M.I.Gibson@warwick.ac.uk; frank.vanhaecke@ugent.be |
Keywords: | gold nanorods; gold nanorods conjugated with synthetic glycopolymers;;high-resolution single-particle inductively coupled plasma-mass;spectrometry; electrical asymmetric-flow field-flow-fractionation;combined with multi-angle light scattering | Document URI: | http://hdl.handle.net/1942/35860 | e-ISSN: | 2079-4991 | DOI: | 10.3390/nano11102720 | ISI #: | WOS:000713669900001 | Rights: | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2022 |
| Appears in Collections: | Research publications |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| nanomaterials-11-02720-v2.pdf | Published version | 1.49 MB | Adobe PDF | View/Open |
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