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http://hdl.handle.net/1942/35861
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DC Field | Value | Language |
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dc.contributor.author | Verheyen, Veerle J. | - |
dc.contributor.author | Remy, Sylvie | - |
dc.contributor.author | Govarts, Eva | - |
dc.contributor.author | Colles, Ann | - |
dc.contributor.author | Rodriguez Martin, Laura | - |
dc.contributor.author | Koppen, Gudrun | - |
dc.contributor.author | Voorspoels, Stefan | - |
dc.contributor.author | BRUCKERS, Liesbeth | - |
dc.contributor.author | BIJNENS, Esmee | - |
dc.contributor.author | VOS, Stijn | - |
dc.contributor.author | Morrens, Bert | - |
dc.contributor.author | Coertjens, Dries | - |
dc.contributor.author | De Decker, Annelies | - |
dc.contributor.author | Franken, Carmen | - |
dc.contributor.author | Den Hond, Elly | - |
dc.contributor.author | Nelen, Vera | - |
dc.contributor.author | Covaci, Adrian | - |
dc.contributor.author | Loots, Ilse | - |
dc.contributor.author | De Henauw, Stefaan | - |
dc.contributor.author | Van Larebeke, Nicolas | - |
dc.contributor.author | Teughels, Caroline | - |
dc.contributor.author | NAWROT, Tim | - |
dc.contributor.author | Schoeters, Greet | - |
dc.date.accessioned | 2021-11-24T13:54:33Z | - |
dc.date.available | 2021-11-24T13:54:33Z | - |
dc.date.issued | 2021 | - |
dc.date.submitted | 2021-11-19T09:05:18Z | - |
dc.identifier.citation | TOXICS, 9 (10) , p. 245 (Art N° 245) | - |
dc.identifier.uri | http://hdl.handle.net/1942/35861 | - |
dc.description.abstract | Polycyclic aromatic hydrocarbons (PAHs) are environmental pollutants of public health concern. Multiple biological mechanisms have been hypothesized to contribute to PAHs-associated adverse health effects. Little is known about the impact of PAHs on endocrine stress and inflammation in adolescence. We examined 393 Flemish adolescents (14-15 years) cross-sectionally, measured urinary concentrations of hydroxylated naphthalene, fluorene, phenanthrene and pyrene metabolites, and calculated the sum of all measured metabolites. We determined hair cortisol concentration (HCC) as endocrine stress biomarker, leucocyte counts and neutrophil-lymphocyte ratio (NLR) in peripheral blood as inflammatory biomarkers, and urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) concentration as oxidative stress biomarker. Exposure-response associations were analyzed by multiple regression, adjusted for a priori selected covariates. A doubling of 1-hydroxypyrene concentration was associated with a factor of 1.13 (95% CI: 1.03, 1.24) increase in HCC and a factor of 1.07 (95% CI: 1.02, 1.13) increase in 8-oxodG. Doublings of 2- and 3-hydroxyphenanthrene concentrations were associated with a factor of 1.08 (95% CI: 1.02, 1.14) and 1.06 (95% CI: 1.00, 1.12) increase in 8-oxodG, respectively. Doubling of 2-hydroxyphenanthrene and of the sum of 2- and 3-hydroxyfluorene was associated with, respectively, a factor of 1.08 (95% CI: 1.02, 1.14) and 1.06 (95% CI: 1.01, 1.13) increase in NLR. Our results indicate the glucocorticoid pathway as a potential target for PAH exposure in adolescents and suggest oxidative stress, endocrine stress, and inflammation in adolescence as underlying mechanisms and early markers for PAH-related adverse health effects.</p> | - |
dc.description.sponsorship | Government of Flanders, Department of Environment & Spatial Development; Flemish Center of Expertise on Environment and Health | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.rights | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). | - |
dc.subject.other | adolescents; human biomonitoring; Flemish Environment and Health Study | - |
dc.subject.other | (FLEHS); polycyclic aromatic hydrocarbons; hair cortisol concentration; | - |
dc.subject.other | neutrophil-lymphocyte ratio; 8-oxo-7,8-dihydro-2-deoxyguanosine | - |
dc.title | Urinary Polycyclic Aromatic Hydrocarbon Metabolites Are Associated with Biomarkers of Chronic Endocrine Stress, Oxidative Stress, and Inflammation in Adolescents: FLEHS-4 (2016–2020) | - |
dc.type | Journal Contribution | - |
dc.identifier.issue | 10 | - |
dc.identifier.volume | 9 | - |
local.format.pages | 21 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Verheyen, VJ (corresponding author), Flemish Inst Technol Res VITO, VITO Hlth, Boeretang 200, B-2400 Mol, Belgium.; Verheyen, VJ (corresponding author), Univ Antwerp, Dept Biomed Sci, Univ Pl 1, B-2610 Antwerp, Belgium. | - |
dc.description.notes | veerle.verheyen@vito.be; sylvie.remy@vito.be; eva.govarts@vito.be; | - |
dc.description.notes | ann.colles@vito.be; laura.rodriguezmartin@vito.be; | - |
dc.description.notes | gudrun.koppen@vito.be; stefan.voorspoels@vito.be; | - |
dc.description.notes | Liesbeth.bruckers@uhasselt.be; bert.morrens@uantwerpen.be; | - |
dc.description.notes | stijn.vos@uhasselt.be; bert.morrens@uantwerpen.be; | - |
dc.description.notes | dries.coertjens@uantwerpen.be; Annelies.DEDECKER@provincieantwerpen.be; | - |
dc.description.notes | Carmen.Franken@provincieantwerpen.be; | - |
dc.description.notes | elly.denhond@provincieantwerpen.be; vera.NELEN@provincieantwerpen.be; | - |
dc.description.notes | adrian.covaci@uantwerpen.be; ilse.loots@uantwerpen.be; | - |
dc.description.notes | stefaan.dehenauw@ugent.be; nicolas.vanlarebeke@ugent.be; | - |
dc.description.notes | caroline.teughels@vlaanderen.be; tim.nawrot@uhasselt.be; | - |
dc.description.notes | greet.schoeters@vito.be | - |
local.publisher.place | ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 245 | - |
dc.identifier.doi | 10.3390/toxics9100245 | - |
dc.identifier.isi | WOS:000713416000001 | - |
dc.contributor.orcid | Verheyen, Veerle/0000-0002-5262-5665; Covaci, | - |
dc.contributor.orcid | Adrian/0000-0003-0527-1136; Colles, Ann/0000-0002-6629-7973; Rodriguez | - |
dc.contributor.orcid | Martin, Laura/0000-0001-6630-411X | - |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
local.description.affiliation | [Verheyen, Veerle J.; Remy, Sylvie; Govarts, Eva; Colles, Ann; Rodriguez Martin, Laura; Koppen, Gudrun; Schoeters, Greet] Flemish Inst Technol Res VITO, VITO Hlth, Boeretang 200, B-2400 Mol, Belgium. | - |
local.description.affiliation | [Verheyen, Veerle J.; Schoeters, Greet] Univ Antwerp, Dept Biomed Sci, Univ Pl 1, B-2610 Antwerp, Belgium. | - |
local.description.affiliation | [Voorspoels, Stefan] Flemish Inst Technol Res VITO, VITO GOAL, Boeretang 200, B-2400 Mol, Belgium. | - |
local.description.affiliation | [Bruckers, Liesbeth] Hasselt Univ, Data Sci Inst, I BioStat, Martelarenlaan 42, B-3500 Hasselt, Belgium. | - |
local.description.affiliation | [Bijnens, Esmee M.; Vos, Stijn; Nawrot, Tim S.] Hasselt Univ, Ctr Environm Sci, Agoralaan Bldg D, B-3590 Diepenbeek, Belgium. | - |
local.description.affiliation | [Morrens, Bert; Coertjens, Dries; Loots, Ilse] Univ Antwerp, Fac Social Sci, Dept Sociol, Sint Jacobstraat 2, B-2000 Antwerp, Belgium. | - |
local.description.affiliation | [De Decker, Annelies; Franken, Carmen; Den Hond, Elly; Nelen, Vera] Prov Inst Hyg, Kronenburgstr 45, B-2000 Antwerp, Belgium. | - |
local.description.affiliation | [Covaci, Adrian] Univ Antwerp, Toxicol Ctr, Univ Pl 1, B-2610 Antwerp, Belgium. | - |
local.description.affiliation | [De Henauw, Stefaan] Univ Ghent, Fac Med & Hlth Sci, Dept Publ Hlth & Primary Care, Pintelaan 185, B-9000 Ghent, Belgium. | - |
local.description.affiliation | [Van Larebeke, Nicolas] Vrije Univ Brussel, Analyt Environm & Geochem, B-1050 Brussels, Belgium. | - |
local.description.affiliation | [Van Larebeke, Nicolas] Univ Ghent, Dept Radiotherapy & Expt Cancerol, B-9000 Ghent, Belgium. | - |
local.description.affiliation | [Teughels, Caroline] Flemish Planning Bur Environm & Spatial Dev, Koning Albert II Laan 20,Bus 8, B-1000 Brussels, Belgium. | - |
local.uhasselt.international | no | - |
item.validation | ecoom 2022 | - |
item.accessRights | Open Access | - |
item.fullcitation | Verheyen, Veerle J.; Remy, Sylvie; Govarts, Eva; Colles, Ann; Rodriguez Martin, Laura; Koppen, Gudrun; Voorspoels, Stefan; BRUCKERS, Liesbeth; BIJNENS, Esmee; VOS, Stijn; Morrens, Bert; Coertjens, Dries; De Decker, Annelies; Franken, Carmen; Den Hond, Elly; Nelen, Vera; Covaci, Adrian; Loots, Ilse; De Henauw, Stefaan; Van Larebeke, Nicolas; Teughels, Caroline; NAWROT, Tim & Schoeters, Greet (2021) Urinary Polycyclic Aromatic Hydrocarbon Metabolites Are Associated with Biomarkers of Chronic Endocrine Stress, Oxidative Stress, and Inflammation in Adolescents: FLEHS-4 (2016–2020). In: TOXICS, 9 (10) , p. 245 (Art N° 245). | - |
item.fulltext | With Fulltext | - |
item.contributor | Verheyen, Veerle J. | - |
item.contributor | Remy, Sylvie | - |
item.contributor | Govarts, Eva | - |
item.contributor | Colles, Ann | - |
item.contributor | Rodriguez Martin, Laura | - |
item.contributor | Koppen, Gudrun | - |
item.contributor | Voorspoels, Stefan | - |
item.contributor | BRUCKERS, Liesbeth | - |
item.contributor | BIJNENS, Esmee | - |
item.contributor | VOS, Stijn | - |
item.contributor | Morrens, Bert | - |
item.contributor | Coertjens, Dries | - |
item.contributor | De Decker, Annelies | - |
item.contributor | Franken, Carmen | - |
item.contributor | Den Hond, Elly | - |
item.contributor | Nelen, Vera | - |
item.contributor | Covaci, Adrian | - |
item.contributor | Loots, Ilse | - |
item.contributor | De Henauw, Stefaan | - |
item.contributor | Van Larebeke, Nicolas | - |
item.contributor | Teughels, Caroline | - |
item.contributor | NAWROT, Tim | - |
item.contributor | Schoeters, Greet | - |
crisitem.journal.eissn | 2305-6304 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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toxics-09-00245-v2.pdf | Published version | 4.59 MB | Adobe PDF | View/Open |
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