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http://hdl.handle.net/1942/35898
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DC Field | Value | Language |
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dc.contributor.author | Rasmussen, N. H. | - |
dc.contributor.author | Sarodnik, C. | - |
dc.contributor.author | Bours, S. P. G. | - |
dc.contributor.author | Schaper, N. C. | - |
dc.contributor.author | Souverein, P. C. | - |
dc.contributor.author | Jensen, M. H. | - |
dc.contributor.author | Driessen, J. H. M. | - |
dc.contributor.author | VAN DEN BERGH, Joop | - |
dc.contributor.author | Vestergaard, P. | - |
dc.date.accessioned | 2021-11-25T17:15:58Z | - |
dc.date.available | 2021-11-25T17:15:58Z | - |
dc.date.issued | 2021 | - |
dc.date.submitted | 2021-10-28T08:50:24Z | - |
dc.identifier.citation | Osteoporosis international, 33(3), p. 599-610. | - |
dc.identifier.issn | 0937-941X | - |
dc.identifier.uri | http://hdl.handle.net/1942/35898 | - |
dc.description.abstract | Higher incidences of fractures are seen in people with type 1 diabetes (T1D), but knowledge on different fracture sites is sparse. We found a higher incidence mainly for distal fracture sites in people with T1D compared to controls. It must be further studied which fractures attributed to the higher incidence rates (IRs) at specific sites. Introduction People with T1D have a higher incidence of fractures compared to the general population. However, sparse knowledge exists on the incidence rates of individual fracture sites. Therefore, we examined the incidence of various fracture sites in people with newly treated T1D compared to matched controls. Methods All people from the UK Clinical Practice Research Datalink GOLD (1987-2017), of all ages with a T1D diagnosis code (n = 6381), were included. People with T1D were matched by year of birth, sex, and practice to controls (n = 6381). Fracture IRs and incidence rate ratios (IRRs) were calculated. Analyses were stratified by fracture site and sex. Results The IR of all fractures was significantly higher in people with T1D compared to controls (IRR: 1.39 (CI95%: 1.24-1.55)). Compared to controls, the IRR for people with T1D was higher for several fracture sites including carpal (IRR: 1.41 (CI95%: 1.14-1.75)), clavicle (IRR: 2.10 (CI95%: 1.18-3.74)), foot (IRR: 1.70 (CI95%: 1.23-2.36)), humerus (IRR: 1.46 (CI95%: 1.04-2.05)), and tibia/fibula (IRR: 1.67 CI95%: 1.08-2.59)). In women with T1D, higher IRs were seen at the ankle (IRR: 2.25 (CI95%: 1.10-4.56)) and foot (IRR: 2.11 (CI95%: 1.27-3.50)), whereas in men with T1D, higher IRs were seen for carpal (IRR: 1.45 (CI95%: 1.14-1.86)), clavicle (IRR: 2.13 (CI95%: 1.13-4.02)), and humerus (IRR: 1.77 (CI95%: 1.10-2.83)) fractures. Conclusion The incidence of carpal, clavicle, foot, humerus, and tibia/fibula fractures was higher in newly treated T1D, but there was no difference at other fracture sites compared to controls. Therefore, the higher incidence of fractures in newly treated people with T1D has been found mainly for distal fracture sites. | - |
dc.description.sponsorship | Novo Nordisk grant - Novo Nordisk Foundation [NNF18OC0052064] | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER LONDON LTD | - |
dc.subject.other | Fracture pattern; Incident fractures; Type 1 diabetes | - |
dc.title | The pattern of incident fractures according to fracture site in people with T1D | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 610 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 599 | - |
dc.identifier.volume | 33 | - |
local.format.pages | 12 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Rasmussen, NH (corresponding author), Aalborg Univ Hosp, Steno Diabet Ctr North Denmark, Aalborg, Denmark. | - |
dc.description.notes | nicklas.rasmussen@rn.dk | - |
local.publisher.place | 236 GRAYS INN RD, 6TH FLOOR, LONDON WC1X 8HL, ENGLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1007/s00198-021-06175-z | - |
dc.identifier.isi | WOS:000705775100001 | - |
dc.contributor.orcid | Jensen, Morten Hasselstrom/0000-0002-6649-8644 | - |
dc.identifier.eissn | 1433-2965 | - |
dc.identifier.eissn | 1433-2965 | - |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
local.description.affiliation | [Rasmussen, N. H.; Vestergaard, P.] Aalborg Univ Hosp, Steno Diabet Ctr North Denmark, Aalborg, Denmark. | - |
local.description.affiliation | [Sarodnik, C.; Driessen, J. H. M.; van den Bergh, J. P. W.] Maastricht Univ, NUTRIM Res Sch, Maastricht, Netherlands. | - |
local.description.affiliation | [Bours, S. P. G.; Schaper, N. C.; van den Bergh, J. P. W.] Maastricht Univ, Dept Internal Med, Med Ctr, Maastricht, Netherlands. | - |
local.description.affiliation | [Bours, S. P. G.; Schaper, N. C.] Maastricht Univ, CAPHRI Res Sch, Maastricht, Netherlands. | - |
local.description.affiliation | [Souverein, P. C.; Driessen, J. H. M.] Univ Utrecht, Utrecht Inst Pharmaceut Sci, Div Pharmacoepidemiol & Clin Pharmacol, Utrecht, Netherlands. | - |
local.description.affiliation | [Jensen, M. H.] Aalborg Univ, Dept Hlth Sci & Technol, Fredrik Bajers Vej 7, DK-9210 Aalborg, Denmark. | - |
local.description.affiliation | [Driessen, J. H. M.] Maastricht Univ, Dept Clin Pharm & Toxicol, Med Ctr, Maastricht, Netherlands. | - |
local.description.affiliation | [Driessen, J. H. M.] Maastricht Univ, Cardiovasc Res Inst Maastricht CARIM, Maastricht, Netherlands. | - |
local.description.affiliation | [van den Bergh, J. P. W.] VieCuri Med Ctr, Dept Internal Med, Venlo, Netherlands. | - |
local.description.affiliation | [van den Bergh, J. P. W.] Univ Hasselt, Fac Med & Life Sci, Hasselt, Belgium. | - |
local.uhasselt.international | yes | - |
item.validation | ecoom 2022 | - |
item.contributor | Rasmussen, N. H. | - |
item.contributor | Sarodnik, C. | - |
item.contributor | Bours, S. P. G. | - |
item.contributor | Schaper, N. C. | - |
item.contributor | Souverein, P. C. | - |
item.contributor | Jensen, M. H. | - |
item.contributor | Driessen, J. H. M. | - |
item.contributor | VAN DEN BERGH, Joop | - |
item.contributor | Vestergaard, P. | - |
item.accessRights | Restricted Access | - |
item.fullcitation | Rasmussen, N. H.; Sarodnik, C.; Bours, S. P. G.; Schaper, N. C.; Souverein, P. C.; Jensen, M. H.; Driessen, J. H. M.; VAN DEN BERGH, Joop & Vestergaard, P. (2021) The pattern of incident fractures according to fracture site in people with T1D. In: Osteoporosis international, 33(3), p. 599-610.. | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 0937-941X | - |
crisitem.journal.eissn | 1433-2965 | - |
Appears in Collections: | Research publications |
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s00198-021-06175-z.pdf Restricted Access | Published version | 703 kB | Adobe PDF | View/Open Request a copy |
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