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http://hdl.handle.net/1942/35901
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DC Field | Value | Language |
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dc.contributor.author | Lemmens, Sophie | - |
dc.contributor.author | LUYTS, Martial | - |
dc.contributor.author | Gerrits, Nele | - |
dc.contributor.author | IVANOVA, Anna | - |
dc.contributor.author | Landtmeeters, Charlien | - |
dc.contributor.author | Peeters, Reinout | - |
dc.contributor.author | Simons, Anne-Sophie | - |
dc.contributor.author | Vercauteren, Julie | - |
dc.contributor.author | Sunaric-Megevand, Gordana | - |
dc.contributor.author | Van Keer, Karel | - |
dc.contributor.author | MOLENBERGHS, Geert | - |
dc.contributor.author | DE BOEVER, Patrick | - |
dc.contributor.author | Stalmans, Ingeborg | - |
dc.date.accessioned | 2021-11-25T19:18:56Z | - |
dc.date.available | 2021-11-25T19:18:56Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2021-11-19T09:17:13Z | - |
dc.identifier.citation | ACTA OPHTHALMOLOGICA, 100(5), p. E1112-E1119 | - |
dc.identifier.issn | 1755-375X | - |
dc.identifier.uri | http://hdl.handle.net/1942/35901 | - |
dc.description.abstract | Purpose This cross-sectional study investigates the association between retinal vessel complexity and age and studies the effects of cardiovascular health determinants. Methods Retinal vessel complexity was assessed by calculating the box-counting fractal dimension (D-f) from digital fundus photographs of 850 subjects (3-97 years). All photographs were labelled as 'non-pathological' by the treating ophthalmologist. Results Statistical models showed a significantly decreasing relationship between age and D-f (linear: R-squared = 0.1897, p < 0.0001; quadratic: R-squared = 0.2343, p < 0.0001; cubic: R-squared = 0.2721, p < 0.0001), with the cubic regression model offering the best compromise between accuracy and model simplicity. Multivariate cubic regression showed that age, spherical equivalent and smoking behaviour have an effect (p < 0.0001) on D-f. A significantly increasing effect of the number of pack-years on D-f was observed (effect: 0.0004, p = 0.0017), as well as a significantly decreasing effect of years since tobacco abstinence (effect: -0.0149, p < 0.0001). Conclusion We propose using a cubic trend with age, refractive error and smoking behaviour when interpreting retinal vessel complexity. | - |
dc.description.sponsorship | Vlaamse Instelling voor Technologisch Onderzoek [PhD grant] Funding Source: Medline | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.rights | 2021 The Authors. Acta Ophthalmologica published by John Wiley & Sons Ltd on behalf of Acta OphthalmologicaScandinavica Foundation.This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivsLicense, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made | - |
dc.subject.other | age | - |
dc.subject.other | cardiovascular health | - |
dc.subject.other | fractal dimension | - |
dc.subject.other | refractive error | - |
dc.subject.other | retinal vasculature | - |
dc.subject.other | smoking | - |
dc.title | Age-related changes in the fractal dimension of the retinal microvasculature, effects of cardiovascular risk factors and smoking behaviour | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | E1119 | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | E1112 | - |
dc.identifier.volume | 100 | - |
local.format.pages | 8 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Lemmens, S (corresponding author), Univ Hosp UZ Leuven, Dept Ophthalmol, Herestr 49, B-3000 Leuven, Belgium. | - |
dc.description.notes | sophie.1.lemmens@uzleuven.be | - |
local.publisher.place | 111 RIVER ST, HOBOKEN 07030-5774, NJ USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1111/aos.15047 | - |
dc.identifier.pmid | 34747106 | - |
dc.identifier.isi | WOS:000715154800001 | - |
dc.identifier.eissn | 1755-3768 | - |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
local.description.affiliation | [Lemmens, Sophie; Van Keer, Karel; Stalmans, Ingeborg] Univ Hosp UZ Leuven, Dept Ophthalmol, Herestr 49, B-3000 Leuven, Belgium. | - |
local.description.affiliation | [Lemmens, Sophie; Landtmeeters, Charlien; Peeters, Reinout; Simons, Anne-Sophie; Vercauteren, Julie; Van Keer, Karel; Stalmans, Ingeborg] Katholieke Univ Leuven, Dept Neurosci, Biomed Sci Grp, Res Grp Ophthalmol, Leuven, Belgium. | - |
local.description.affiliation | [Lemmens, Sophie; Gerrits, Nele; De Boever, Patrick] VITO Flemish Inst Technol Res, Hlth Unit, Mol, Belgium. | - |
local.description.affiliation | [Luyts, Martial; Ivanova, Anna; Molenberghs, Geert] Katholieke Univ Leuven, L Biostat, Leuven, Belgium. | - |
local.description.affiliation | [Luyts, Martial; Ivanova, Anna; Molenberghs, Geert] UHasselt, Leuven, Belgium. | - |
local.description.affiliation | [Sunaric-Megevand, Gordana] Mem A de Rothschild, Clin Res Ctr, Geneva, Switzerland. | - |
local.description.affiliation | [De Boever, Patrick] Hasselt Univ, Ctr Environm Sci, Diepenbeek, Belgium. | - |
local.description.affiliation | [De Boever, Patrick] Univ Antwerp, Dept Biol, Antwerp, Belgium. | - |
local.uhasselt.international | yes | - |
item.validation | ecoom 2022 | - |
item.contributor | Lemmens, Sophie | - |
item.contributor | LUYTS, Martial | - |
item.contributor | Gerrits, Nele | - |
item.contributor | IVANOVA, Anna | - |
item.contributor | Landtmeeters, Charlien | - |
item.contributor | Peeters, Reinout | - |
item.contributor | Simons, Anne-Sophie | - |
item.contributor | Vercauteren, Julie | - |
item.contributor | Sunaric-Megevand, Gordana | - |
item.contributor | Van Keer, Karel | - |
item.contributor | MOLENBERGHS, Geert | - |
item.contributor | DE BOEVER, Patrick | - |
item.contributor | Stalmans, Ingeborg | - |
item.accessRights | Open Access | - |
item.fullcitation | Lemmens, Sophie; LUYTS, Martial; Gerrits, Nele; IVANOVA, Anna; Landtmeeters, Charlien; Peeters, Reinout; Simons, Anne-Sophie; Vercauteren, Julie; Sunaric-Megevand, Gordana; Van Keer, Karel; MOLENBERGHS, Geert; DE BOEVER, Patrick & Stalmans, Ingeborg (2022) Age-related changes in the fractal dimension of the retinal microvasculature, effects of cardiovascular risk factors and smoking behaviour. In: ACTA OPHTHALMOLOGICA, 100(5), p. E1112-E1119. | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 1755-375X | - |
crisitem.journal.eissn | 1755-3768 | - |
Appears in Collections: | Research publications |
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Acta Ophthalmologica - 2021 - Lemmens - Age‐related changes in the fractal dimension of the retinal microvasculature .pdf | Published version | 353.68 kB | Adobe PDF | View/Open |
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