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http://hdl.handle.net/1942/35909
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DC Field | Value | Language |
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dc.contributor.author | BUSSCHOTS, Dana | - |
dc.contributor.author | BIELEN, Rob | - |
dc.contributor.author | KOC, Ozgur | - |
dc.contributor.author | HEYENS, Leen | - |
dc.contributor.author | Verrando, Rita | - |
dc.contributor.author | de Galocsy, Chantal | - |
dc.contributor.author | Van Steenkiste, Christophe | - |
dc.contributor.author | Nevens, Frederik | - |
dc.contributor.author | Midgard, Havard | - |
dc.contributor.author | Dalgard, Olav | - |
dc.contributor.author | ROBAEYS, Geert | - |
dc.date.accessioned | 2021-11-26T13:28:39Z | - |
dc.date.available | 2021-11-26T13:28:39Z | - |
dc.date.issued | 2021 | - |
dc.date.submitted | 2021-10-28T08:39:54Z | - |
dc.identifier.citation | HARM REDUCTION JOURNAL, 18 (1) (Art N° 102) | - |
dc.identifier.uri | http://hdl.handle.net/1942/35909 | - |
dc.description.abstract | Background: There is currently no systematic screening for hepatitis C (HCV) reinfection in people who inject drugs (PWID) after treatment in Belgium. However, in a recent meta-analysis, the overall HCV reinfection rate was 5.9/100 person-years (PY) among PWID. Accordingly, this study was undertaken to investigate the reinfection rate in former and active PWID who achieved the end of treatment response after direct-acting antiviral (DAA) treatment in Belgium. Methods: This observational cross-sectional study recruited individuals with a history of injecting drug use who had achieved the end of treatment response to any DAA treatment between 2015 and 2020. Participants were offered a post-treatment HCV RNA test. Results: Eighty-five potential participants were eligible to participate and contacted, of whom 60 participants were enrolled in the study with a median age of 51.0 (IQR 44.3-56.0) years; it was reported that 23.3% continued to inject drugs intravenously after DAA treatment. Liver cirrhosis was present in 12.9%. The majority had genotype 1a (51.7%) or genotype 3 (15.0%) infection. We detected no reinfections in this study population. The total time patients were followed up for reinfection in the study was 78.5 PY (median 1.0 years IQR 0.4-2.0). Conclusion: Reinfection after successful treatment with DAA initially appears to be very low in Belgian PWID. Therefore, efforts should be made to screen individuals with persistent risk behaviors for reinfection systematically. In addition, a national HCV registry should be established to accurately define the burden of HCV infection and reinfection in Belgium and support the elimination of viral hepatitis C in Europe. | - |
dc.description.sponsorship | Gilead SciencesGilead Sciences [V-2911] | - |
dc.language.iso | en | - |
dc.publisher | BMC | - |
dc.rights | © The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, w | - |
dc.subject.other | Reinfection; Hepatitis C virus; People who inject drugs; Direct-acting | - |
dc.subject.other | antivirals | - |
dc.title | Hepatitis C reinfection in former and active injecting drug users in Belgium | - |
dc.type | Journal Contribution | - |
dc.identifier.issue | 1 | - |
dc.identifier.volume | 18 | - |
local.format.pages | 7 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Busschots, D (corresponding author), Hasselt Univ, Fac Med & Life Sci, Martelarenlaan 42, B-3500 Diepenbeek, Hasselt, Belgium. | - |
dc.description.notes | dana.busschots@uhasselt.be | - |
local.publisher.place | CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 102 | - |
dc.identifier.doi | 10.1186/s12954-021-00552-x | - |
dc.identifier.isi | WOS:000706719900001 | - |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
local.description.affiliation | [Busschots, Dana; Bielen, Rob; Koc, Ozgur M.; Heyens, Leen; Robaeys, Geert] Hasselt Univ, Fac Med & Life Sci, Martelarenlaan 42, B-3500 Diepenbeek, Hasselt, Belgium. | - |
local.description.affiliation | [Busschots, Dana; Bielen, Rob; Koc, Ozgur M.; Heyens, Leen; Robaeys, Geert] Ziekenhuis Oost Limburg, Dept Gastroenterol & Hepatol, Genk, Belgium. | - |
local.description.affiliation | [Koc, Ozgur M.; Heyens, Leen] Maastricht Univ, Med Ctr, Sch NUTRIM, Maastricht, Netherlands. | - |
local.description.affiliation | [Verrando, Rita] zorGGroep Zin, Hasselt, Belgium. | - |
local.description.affiliation | [Van Steenkiste, Christophe] AZ Middelares, Dept Gastroenterol & Hepatol, Ghent, Belgium. | - |
local.description.affiliation | [Nevens, Frederik; Robaeys, Geert] Univ Hosp KU, Dept Gastroenterol & Hepatol, Leuven, Belgium. | - |
local.description.affiliation | [Midgard, Havard; Dalgard, Olav] Akershus Univ Hosp, Dept Infect Dis, Lorenskog, Norway. | - |
local.uhasselt.international | yes | - |
item.validation | ecoom 2022 | - |
item.fulltext | With Fulltext | - |
item.fullcitation | BUSSCHOTS, Dana; BIELEN, Rob; KOC, Ozgur; HEYENS, Leen; Verrando, Rita; de Galocsy, Chantal; Van Steenkiste, Christophe; Nevens, Frederik; Midgard, Havard; Dalgard, Olav & ROBAEYS, Geert (2021) Hepatitis C reinfection in former and active injecting drug users in Belgium. In: HARM REDUCTION JOURNAL, 18 (1) (Art N° 102). | - |
item.accessRights | Open Access | - |
item.contributor | BUSSCHOTS, Dana | - |
item.contributor | BIELEN, Rob | - |
item.contributor | KOC, Ozgur | - |
item.contributor | HEYENS, Leen | - |
item.contributor | Verrando, Rita | - |
item.contributor | de Galocsy, Chantal | - |
item.contributor | Van Steenkiste, Christophe | - |
item.contributor | Nevens, Frederik | - |
item.contributor | Midgard, Havard | - |
item.contributor | Dalgard, Olav | - |
item.contributor | ROBAEYS, Geert | - |
crisitem.journal.issn | 1477-7517 | - |
crisitem.journal.eissn | 1477-7517 | - |
Appears in Collections: | Research publications |
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s12954-021-00552-x.pdf | Published version | 819.83 kB | Adobe PDF | View/Open |
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