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http://hdl.handle.net/1942/35938
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DC Field | Value | Language |
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dc.contributor.author | LOIX, Melanie | - |
dc.contributor.author | BOGIE, Jeroen | - |
dc.contributor.author | HENDRIKS, Jerome | - |
dc.contributor.author | HAIDAR, Mansour | - |
dc.date.accessioned | 2021-11-29T16:24:27Z | - |
dc.date.available | 2021-11-29T16:24:27Z | - |
dc.date.issued | 2021 | - |
dc.date.submitted | 2021-10-28T08:01:37Z | - |
dc.identifier.citation | Trends in endocrinology and metabolism, 32 (11) , p. 941 -951 | - |
dc.identifier.uri | http://hdl.handle.net/1942/35938 | - |
dc.description.abstract | Lipophagy is the process of selective degradation of lipid droplets (LDs) by autophagy. Several studies have highlighted the importance of lipophagy in regulating cellular lipid levels in various tissues and disease conditions. In recent years, disruption of autophagy and accumulation of LDs have been reported as pathological hallmarks in several neurodegenerative and neuroinflammatory diseases, raising the question whether lipophagy is a process that is important in the progression of these disorders. This supports the growing interest in lipid metabolism as a major player in neurodegeneration, and the emerging understanding of several neurological pathologies as not only proteinopathies but also lipidopathies. In this review we discuss the importance of lipophagy in the most common central nervous system diseases. We examine the latest evidence for the reported interplay between abnormalities in lipid accumulation and autophagy, and propose lipophagy as a potentially important mechanism in neurodegeneration. | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE LONDON | - |
dc.rights | © 2021 Elsevier Ltd. All rights reserved. | - |
dc.title | Lipophagy: a new player in CNS disorders | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 951 | - |
dc.identifier.issue | 11 | - |
dc.identifier.spage | 941 | - |
dc.identifier.volume | 32 | - |
local.format.pages | 11 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Hendriks, JJA (corresponding author), Hasselt Univ, Biomed Res Inst, Dept Immunol & Infect, Diepenbeek, Belgium. | - |
dc.description.notes | jerome.hendriks@uhasselt.be | - |
local.publisher.place | 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Review | - |
dc.identifier.doi | 10.1016/j.tem.2021.08.010 | - |
dc.identifier.isi | WOS:000707636500010 | - |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
local.description.affiliation | [Haidar, Mansour; Loix, Melanie; Bogie, Jeroen F. J.; Hendriks, Jerome J. A.] Hasselt Univ, Biomed Res Inst, Dept Immunol & Infect, Diepenbeek, Belgium. | - |
local.uhasselt.international | no | - |
item.fullcitation | LOIX, Melanie; BOGIE, Jeroen; HENDRIKS, Jerome & HAIDAR, Mansour (2021) Lipophagy: a new player in CNS disorders. In: Trends in endocrinology and metabolism, 32 (11) , p. 941 -951. | - |
item.fulltext | No Fulltext | - |
item.validation | ecoom 2022 | - |
item.contributor | LOIX, Melanie | - |
item.contributor | BOGIE, Jeroen | - |
item.contributor | HENDRIKS, Jerome | - |
item.contributor | HAIDAR, Mansour | - |
item.accessRights | Closed Access | - |
crisitem.journal.issn | 1043-2760 | - |
crisitem.journal.eissn | 1879-3061 | - |
Appears in Collections: | Research publications |
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