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http://hdl.handle.net/1942/35950
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DC Field | Value | Language |
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dc.contributor.author | BUYSE, Marc | - |
dc.contributor.author | Saad, Everardo D. | - |
dc.contributor.author | Peron, Julien | - |
dc.contributor.author | Chiem, Jean-Christophe | - |
dc.contributor.author | De Backer, Mickael | - |
dc.contributor.author | Cantagallo, Eva | - |
dc.contributor.author | Ciani, Oriana | - |
dc.date.accessioned | 2021-11-29T19:49:57Z | - |
dc.date.available | 2021-11-29T19:49:57Z | - |
dc.date.issued | 2021 | - |
dc.date.submitted | 2021-10-28T09:53:23Z | - |
dc.identifier.citation | JOURNAL OF CLINICAL EPIDEMIOLOGY, 137 , p. 148 -158 | - |
dc.identifier.uri | http://hdl.handle.net/1942/35950 | - |
dc.description.abstract | Objective: The assessment of benefits and harms from experimental treatments often ignores the association between outcomes. In a randomized trial, generalized pairwise comparisons (GPC) can be used to assess a Net Benefit that takes this association into account. Study design and settings: We use GPC to analyze a fictitious trial of treatment versus control, with a binary efficacy outcome (response) and a binary toxicity outcome, as well as data from two actual randomized trials in oncology. In all cases, we compute the Net Benefit for scenarios with different orders of priority between response and toxicity, and a range of odds ratios (ORs) for the association between these outcomes. Results: The GPC Net Benefit was quite different from the benefit/harm computed using marginal treatment effects on response and toxicity. In the fictitious trial using response as first priority, treatment had an unfavorable Net Benefit if OR < 1, but favorable if OR > 1. With OR = 1, the Net Benefit was 0. Results changed drastically using toxicity as first priority. Conclusion: Even in a simple situation, marginal treatment effects can be misleading. In contrast, GPC assesses the Net Benefit as a function of the treatment effects on each outcome, the association between outcomes, and individual patient priorities. (C) 2021 The Authors. Published by Elsevier Inc. | - |
dc.description.sponsorship | Brussels-Capital (Innoviris); EORTC Cancer Research Fund; regions of Wallonia (BioWin Consortium) [7979] | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.rights | © 2021 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license | - |
dc.subject.other | Generalized pairwise comparisons; Prioritized outcomes; Benefit; harm; | - |
dc.subject.other | Net Benefit | - |
dc.title | The Net Benefit of a treatment should take the correlation between benefits and harms into account | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 158 | - |
dc.identifier.spage | 148 | - |
dc.identifier.volume | 137 | - |
local.format.pages | 11 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Buyse, M (corresponding author), Int Inst Drug Dev, San Francisco, CA USA.; Buyse, M (corresponding author), Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat I BioSt, Diepenbeek, Belgium. | - |
dc.description.notes | marc.buyse@iddi.com | - |
local.publisher.place | STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1016/j.jclinepi.2021.03.018 | - |
dc.identifier.isi | WOS:000704355400016 | - |
dc.contributor.orcid | De Backer, Mickael/0000-0003-1669-6391; CIANI, | - |
dc.contributor.orcid | ORIANA/0000-0002-3607-0508 | - |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
local.description.affiliation | [Buyse, Marc] Int Inst Drug Dev, San Francisco, CA USA. | - |
local.description.affiliation | [Buyse, Marc] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat I BioSt, Diepenbeek, Belgium. | - |
local.description.affiliation | [Saad, Everardo D.; Chiem, Jean-Christophe] Int Inst Drug Dev, Louvain La Neuve, Belgium. | - |
local.description.affiliation | [Peron, Julien] Hosp Civils Lyon, Dept Oncol, Pierre Benite, France. | - |
local.description.affiliation | [Peron, Julien] Hosp Civils Lyon, Dept Biostat, Pierre Benite, France. | - |
local.description.affiliation | [Peron, Julien] Univ Lyon 1, CNRS UMR 5558, Biometry & Evolut Biol Lab, Biostat Hlth Team, Villeurbanne, France. | - |
local.description.affiliation | [De Backer, Mickael] Univ Louvain, Inst Stat Biostat & Sci Actuarielles, Biostatist & Sci actuarielles, Louvain La Neuve, Belgium. | - |
local.description.affiliation | [Cantagallo, Eva] European Org Res & Treatment Canc EORTC, Brussels, Belgium. | - |
local.description.affiliation | [Ciani, Oriana] Univ Commerciale L Bocconi, CERGAS, Milan, Italy. | - |
local.description.affiliation | [Ciani, Oriana] Univ Exeter, Med Sch, Evidence Synth & Modelling Hlth Improvement, Exeter, Devon, England. | - |
local.uhasselt.international | yes | - |
item.validation | ecoom 2022 | - |
item.contributor | BUYSE, Marc | - |
item.contributor | Saad, Everardo D. | - |
item.contributor | Peron, Julien | - |
item.contributor | Chiem, Jean-Christophe | - |
item.contributor | De Backer, Mickael | - |
item.contributor | Cantagallo, Eva | - |
item.contributor | Ciani, Oriana | - |
item.accessRights | Open Access | - |
item.fullcitation | BUYSE, Marc; Saad, Everardo D.; Peron, Julien; Chiem, Jean-Christophe; De Backer, Mickael; Cantagallo, Eva & Ciani, Oriana (2021) The Net Benefit of a treatment should take the correlation between benefits and harms into account. In: JOURNAL OF CLINICAL EPIDEMIOLOGY, 137 , p. 148 -158. | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 0895-4356 | - |
crisitem.journal.eissn | 1878-5921 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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net benefit.pdf | Published version | 0 B | Adobe PDF | View/Open |
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