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http://hdl.handle.net/1942/35958
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DC Field | Value | Language |
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dc.contributor.author | EVENS, Tim | - |
dc.contributor.author | Van Hileghem, Lorenz | - |
dc.contributor.author | Dal Dosso, Francesco | - |
dc.contributor.author | Lammertyn, Jeroen | - |
dc.contributor.author | Malek, Olivier | - |
dc.contributor.author | Castagne, Sylvie | - |
dc.contributor.author | Seveno, David | - |
dc.contributor.author | VAN BAEL, Albert | - |
dc.date.accessioned | 2021-11-30T10:36:10Z | - |
dc.date.available | 2021-11-30T10:36:10Z | - |
dc.date.issued | 2021 | - |
dc.date.submitted | 2021-10-28T12:19:54Z | - |
dc.identifier.citation | JOURNAL OF MICRO AND NANO-MANUFACTURING, 9 (3) (Art N° 030902) | - |
dc.identifier.uri | http://hdl.handle.net/1942/35958 | - |
dc.description.abstract | Microneedle arrays contain needlelike microscopic structures, which facilitate drug or vaccine delivery in a minimally invasive way. However, producing hollow microneedles is currently limited by expensive, time consuming and complex microfabrication techniques. In this paper, a novel method to produce hollow polymer microneedles is presented. This method utilizes a femtosecond laser to create hollow microneedle cavities in a mold insert. This mold insert is used in an injection molding process to replicate polymethyl methacrylate microneedles. The combined effect of the mold temperature, volumetric injection rate, and melt temperature on the replication fidelity was evaluated. It was found that the combination of high injection molding parameters facilitated the replication. Furthermore, the functionality of the manufactured hollow microneedles was successfully tested by injecting a controlled flow of colored water into an agarose matrix. The developed methodology enables the production of low-cost, high-volume microneedle devices, which could be a key asset for large scale vaccination campaigns. | - |
dc.description.sponsorship | KU Leuven Interdisciplinary Network [IDN/20/011-MIRACLE] | - |
dc.language.iso | en | - |
dc.publisher | ASME | - |
dc.title | Producing Hollow Polymer Microneedles Using Laser Ablated Molds in an Injection Molding Process | - |
dc.type | Journal Contribution | - |
dc.identifier.issue | 3 | - |
dc.identifier.volume | 9 | - |
local.format.pages | 9 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Evens, T (corresponding author), Dept Mat Engn, Diepenbeek Campus,Wetenschapspk 27, B-3590 Diepenbeek, Belgium. | - |
dc.description.notes | tim.evens@kuleuven.be; Lorenz.vanhileghem@kuleuven.be; | - |
dc.description.notes | Francesco.daldosso@kuleuven.be; Jeroen.lammertyn@kuleuven.be; | - |
dc.description.notes | olivier.malek@sirris.be; sylvie.castagne@kuleuven.be; | - |
dc.description.notes | david.seveno@kuleuven.be; albert.vanbael@kuleuven.be | - |
local.publisher.place | TWO PARK AVE, NEW YORK, NY 10016-5990 USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 030902 | - |
dc.identifier.doi | 10.1115/1.4051456 | - |
dc.identifier.isi | WOS:000702512300007 | - |
dc.contributor.orcid | Van Hileghem, Lorenz/0000-0002-2731-2632; Evens, Tim/0000-0002-2256-5489 | - |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
local.description.affiliation | [Evens, Tim] Dept Mat Engn, Diepenbeek Campus,Wetenschapspk 27, B-3590 Diepenbeek, Belgium. | - |
local.description.affiliation | [Van Hileghem, Lorenz; Dal Dosso, Francesco; Lammertyn, Jeroen] Katholieke Univ Leuven, Biosensors Grp, Dept Biosyst, Willem Croylaan 42,Box 2428, B-3001 Leuven, Belgium. | - |
local.description.affiliation | [Malek, Olivier] Sirris, Precis Mfg, Wetenschapspk 9, B-3590 Diepenbeek, Belgium. | - |
local.description.affiliation | [Castagne, Sylvie] Katholieke Univ Leuven, Dept Mech Engn, Celestijnenlaan 300, B-3001 Leuven, Belgium. | - |
local.description.affiliation | [Castagne, Sylvie] Katholieke Univ Leuven, Flanders Make, MaPS, Celestijnenlaan 300, B-3001 Leuven, Belgium. | - |
local.description.affiliation | [Seveno, David] Katholieke Univ Leuven, Dept Mat Engn, Kasteelpk Arenberg 44, B-3001 Leuven, Belgium. | - |
local.description.affiliation | [Van Bael, Albert] Katholieke Univ Leuven, Dept Mat Engn, Diepenbeek Campus,Wetenschapspk 27, B-3590 Diepenbeek, Belgium. | - |
item.fullcitation | EVENS, Tim; Van Hileghem, Lorenz; Dal Dosso, Francesco; Lammertyn, Jeroen; Malek, Olivier; Castagne, Sylvie; Seveno, David & VAN BAEL, Albert (2021) Producing Hollow Polymer Microneedles Using Laser Ablated Molds in an Injection Molding Process. In: JOURNAL OF MICRO AND NANO-MANUFACTURING, 9 (3) (Art N° 030902). | - |
item.contributor | EVENS, Tim | - |
item.contributor | Van Hileghem, Lorenz | - |
item.contributor | Dal Dosso, Francesco | - |
item.contributor | Lammertyn, Jeroen | - |
item.contributor | Malek, Olivier | - |
item.contributor | Castagne, Sylvie | - |
item.contributor | Seveno, David | - |
item.contributor | VAN BAEL, Albert | - |
item.accessRights | Open Access | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 2166-0468 | - |
crisitem.journal.eissn | 2166-0476 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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Manuscript_ASME_Accepted.pdf | Peer-reviewed author version | 1.14 MB | Adobe PDF | View/Open |
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