Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/35962
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dc.contributor.authorDEFERM, Sebastien-
dc.contributor.authorBERTRAND, Philippe-
dc.contributor.authorVerhaert, David-
dc.contributor.authorDAUW, Jeroen-
dc.contributor.authorVan Keer, Jan M.-
dc.contributor.authorvan de Bruaene, Alexander-
dc.contributor.authorHerregods, Marie-Christine-
dc.contributor.authorMeuris, Bart-
dc.contributor.authorVerbrugghe, Peter-
dc.contributor.authorRex, Steffen-
dc.contributor.authorRega, Filip-
dc.contributor.authorVANDERVOORT, Pieter-
dc.date.accessioned2021-11-30T12:56:02Z-
dc.date.available2021-11-30T12:56:02Z-
dc.date.issued2021-
dc.date.submitted2021-10-28T11:51:57Z-
dc.identifier.citationHEART, 107 (18) , p. 1503 -1509-
dc.identifier.urihttp://hdl.handle.net/1942/35962-
dc.description.abstractObjectives Atrial secondary mitral regurgitation (ASMR) is a clinically distinct form of Carpentier type I mitral regurgitation (MR), rooted in excessive atrial and mitral annular dilation in the absence of left ventricular dysfunction. Mitral valve annuloplasty (MVA) is expected to provide a more durable solution for ASMR than for ventricular secondary MR (VSMR). Yet data on MR recurrence and outcome after MVA for ASMR are scarce. This study sought to investigate surgical outcomes and repair durability in patients with ASMR, as compared with a contemporary group of patients with VSMR. Methods Clinical and echocardiographic data from consecutive patients who underwent MVA to treat ASMR or VSMR in an academic centre were retrospectively analysed. Patient characteristics, operative outcomes, time to recurrence of >= moderate MR and all-cause mortality were compared between patients with ASMR versus VSMR. Results Of the 216 patients analysed, 97 had ASMR opposed to 119 with VSMR and subvalvular leaflet tethering. Patients with ASMR were typically female (68.0% vs 33.6% in VSMR, p<0.001), with a history of atrial fibrillation (76.3% vs 33.6% in VSMR, p<0.001), paralleling a larger left atrial size (p<0.033). At a median follow-up of 3.3 (IQR 1.0-7.3) years, recurrence of >= moderate MR was significantly lower in ASMR versus VSMR (7% vs 25% at 2 years, overall log-rank p=0.001), also when accounting for all-cause death as competing risk (subdistribution HR 0.50 in ASMR, 95% CI 0.29 to 0.88, p=0.016). Moreover, ASMR was associated with better overall survival compared with VSMR (adjusted HR 0.43 95% CI 0.22 to 0.82, p=0.011), independent from baseline European System for Cardiac Operative Risk Evaluation II surgical risk score. Conclusion Prognosis following MVA to treat ASMR is better, compared with VSMR as reflected by lower all-cause mortality and MR recurrence. Early distinction of secondary MR towards underlying ventricular versus atrial disease has important therapeutic implications.-
dc.language.isoen-
dc.publisherBMJ PUBLISHING GROUP-
dc.rights© Author(s) (or their employer(s)) 2021. No commercial re- use.-
dc.subject.othercardiac surgical procedures; atrial fibrillation; mitral valve-
dc.subject.otherinsufficiency-
dc.titleOutcome and durability of mitral valve annuloplasty in atrial secondary mitral regurgitation-
dc.typeJournal Contribution-
dc.identifier.epage1509-
dc.identifier.issue18-
dc.identifier.spage1503-
dc.identifier.volume107-
local.format.pages7-
local.bibliographicCitation.jcatA1-
dc.description.notesDeferm, S (corresponding author), Ziekenhuis Oost Limburg, Cardiol, B-3600 Genk, Limburg, Belgium.-
dc.description.notessebastien.deferm@zol.be-
local.publisher.placeBRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND-
local.type.refereedRefereed-
local.type.specifiedArticle-
dc.identifier.doi10.1136/heartjnl-2021-319045-
dc.identifier.isiWOS:000697845600014-
dc.contributor.orcidVerbrugghe, Peter/0000-0002-8390-1706; Dauw, Jeroen/0000-0003-4605-3450-
local.provider.typewosris-
local.uhasselt.uhpubyes-
local.description.affiliation[Deferm, Sebastien; Bertrand, Philippe B.; Verhaert, David; Dauw, Jeroen; Vandervoort, Pieter M.] Ziekenhuis Oost Limburg, Dept Cardiol, Genk, Belgium.-
local.description.affiliation[Deferm, Sebastien; Bertrand, Philippe B.; Dauw, Jeroen; Vandervoort, Pieter M.] Hasselt Univ, Fac Med & Life Sci, Diepenbeek, Belgium.-
local.description.affiliation[Van Keer, Jan M.; van de Bruaene, Alexander; Herregods, Marie-Christine] Univ Hosp Leuven, Dept Cardiol, Leuven, Belgium.-
local.description.affiliation[Meuris, Bart; Verbrugghe, Peter; Rega, Filip] Univ Hosp Leuven, Dept Cardiac Surg, Leuven, Belgium.-
local.description.affiliation[Rex, Steffen] Univ Hosp Leuven, Dept Anesthesiol & Intens Care, Leuven, Belgium.-
local.uhasselt.internationalno-
item.accessRightsClosed Access-
item.validationecoom 2022-
item.fulltextWith Fulltext-
item.contributorDEFERM, Sebastien-
item.contributorBERTRAND, Philippe-
item.contributorVerhaert, David-
item.contributorDAUW, Jeroen-
item.contributorVan Keer, Jan M.-
item.contributorvan de Bruaene, Alexander-
item.contributorHerregods, Marie-Christine-
item.contributorMeuris, Bart-
item.contributorVerbrugghe, Peter-
item.contributorRex, Steffen-
item.contributorRega, Filip-
item.contributorVANDERVOORT, Pieter-
item.fullcitationDEFERM, Sebastien; BERTRAND, Philippe; Verhaert, David; DAUW, Jeroen; Van Keer, Jan M.; van de Bruaene, Alexander; Herregods, Marie-Christine; Meuris, Bart; Verbrugghe, Peter; Rex, Steffen; Rega, Filip & VANDERVOORT, Pieter (2021) Outcome and durability of mitral valve annuloplasty in atrial secondary mitral regurgitation. In: HEART, 107 (18) , p. 1503 -1509.-
crisitem.journal.issn1355-6037-
crisitem.journal.eissn1468-201X-
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