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http://hdl.handle.net/1942/35965
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DC Field | Value | Language |
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dc.contributor.author | BOGIE, Jeroen | - |
dc.contributor.author | VANMIERLO, Tim | - |
dc.contributor.author | VANMOL, Jasmine | - |
dc.contributor.author | TIMMERMANS, Silke | - |
dc.contributor.author | MAILLEUX, Jo | - |
dc.contributor.author | Wijnands, Erwin | - |
dc.contributor.author | NELISSEN, Katherine | - |
dc.contributor.author | Gustafsson, Jan-Ake | - |
dc.contributor.author | STINISSEN, Piet | - |
dc.contributor.author | WOUTERS, Kristiaan | - |
dc.contributor.author | Steffensen, Knut R. | - |
dc.contributor.author | Mulder, Monique | - |
dc.contributor.author | Zelcer, Noam | - |
dc.contributor.author | HENDRIKS, Jerome | - |
dc.date.accessioned | 2021-11-30T13:41:27Z | - |
dc.date.available | 2021-11-30T13:41:27Z | - |
dc.date.issued | 2021 | - |
dc.date.submitted | 2021-10-28T11:34:35Z | - |
dc.identifier.citation | Journal of autoimmunity (Print), 124 (Art N° 102723) | - |
dc.identifier.uri | http://hdl.handle.net/1942/35965 | - |
dc.description.abstract | The initiation and progression of autoimmune disorders such as multiple sclerosis (MS) is linked to aberrant cholesterol metabolism and overt inflammation. Liver X receptors (LXR) are nuclear receptors that function at the crossroads of cholesterol metabolism and immunity, and their activation is considered a promising therapeutic strategy to attenuate autoimmunity. However, despite clear functional heterogeneity and cell-specific expression profiles, the impact of the individual LXR isoforms on autoimmunity remains poorly understood. Here, we show that LXR alpha and LXR beta have an opposite impact on immune cell function and disease severity in the experimental autoimmune encephalomyelitis model, an experimental MS model. While Lxr alpha deficiency aggravated disease pathology and severity, absence of Lxr beta was protective. Guided by flow cytometry and by using cell-specific knockout models, reduced disease severity in Lxr beta-deficient mice was primarily attributed to changes in peripheral T cell physiology and occurred independent from alterations in microglia function. Collectively, our findings indicate that LXR isoforms play functionally non-redundant roles in autoimmunity, potentially having broad implications for the development of LXR-based therapeutic strategies aimed at dampening autoimmunity and neuroinflammation. | - |
dc.description.sponsorship | FWO 12J9116N 12JG119N 12U7718N G099618N Belgian Charcot Foundation FCS-2016-EG7 | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | - |
dc.rights | © 2021 Elsevier Ltd. All rights reserved | - |
dc.subject.other | Liver X receptors; Cholesterol metabolism; Immunometabolism; | - |
dc.subject.other | Autoimmunity; Multiple sclerosis | - |
dc.title | Liver X receptor beta deficiency attenuates autoimmune-associated neuroinflammation in a T cell-dependent manner | - |
dc.type | Journal Contribution | - |
dc.identifier.volume | 124 | - |
local.format.pages | 9 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Hendriks, JJA (corresponding author), Hasselt Univ, Biomed Res Inst, Dept Immunol & Infect, Diepenbeek, Belgium.; Hendriks, JJA (corresponding author), Univ MS Ctr Hasselt, Pelt, Belgium. | - |
dc.description.notes | jerome.hendriks@uhasselt.be | - |
local.publisher.place | 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 102723 | - |
dc.identifier.doi | 10.1016/j.jaut.2021.102723 | - |
dc.identifier.isi | WOS:000701923300001 | - |
dc.contributor.orcid | Hendriks, Jerome J/0000-0002-7717-8582 | - |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
local.description.affiliation | [Bogie, Jeroen F. J.; Vanmol, Jasmine; Timmermans, Silke; Mailleux, Jo; Nelissen, Katherine; Stinissen, Piet; Hendriks, Jerome J. A.] Hasselt Univ, Biomed Res Inst, Dept Immunol & Infect, Diepenbeek, Belgium. | - |
local.description.affiliation | [Bogie, Jeroen F. J.; Vanmierlo, Tim; Vanmol, Jasmine; Timmermans, Silke; Mailleux, Jo; Nelissen, Katherine; Stinissen, Piet; Hendriks, Jerome J. A.] Univ MS Ctr Hasselt, Pelt, Belgium. | - |
local.description.affiliation | [Vanmierlo, Tim] Hasselt Univ, Biomed Res Inst, Dept Neurosci, Neuroimmune Connect & Repair Lab, Diepenbeek, Belgium. | - |
local.description.affiliation | [Vanmierlo, Tim] Maastricht Univ, Sch Mental Hlth & Neurosci, Div Translat Neurosci, Maastricht, Netherlands. | - |
local.description.affiliation | [Wijnands, Erwin; Wouters, Kristiaan] Maastricht Univ Med Ctr MUMC, Cardiovasc Res Inst Maastricht CARIM, Dept Internal Med, Maastricht, Netherlands. | - |
local.description.affiliation | [Gustafsson, Jan-Ake] Univ Houston, Ctr Nucl Receptors & Cell Signaling, Houston, TX USA. | - |
local.description.affiliation | [Gustafsson, Jan-Ake; Steffensen, Knut R.] Karolinska Inst, Dept Lab Med, Huddinge, Sweden. | - |
local.description.affiliation | [Mulder, Monique] Erasmus MC, Dept Internal Med, Rotterdam, Netherlands. | - |
local.description.affiliation | [Zelcer, Noam] Univ Amsterdam, Acad Med Ctr, Dept Med Biochem, Amsterdam, Netherlands. | - |
local.uhasselt.international | yes | - |
item.fullcitation | BOGIE, Jeroen; VANMIERLO, Tim; VANMOL, Jasmine; TIMMERMANS, Silke; MAILLEUX, Jo; Wijnands, Erwin; NELISSEN, Katherine; Gustafsson, Jan-Ake; STINISSEN, Piet; WOUTERS, Kristiaan; Steffensen, Knut R.; Mulder, Monique; Zelcer, Noam & HENDRIKS, Jerome (2021) Liver X receptor beta deficiency attenuates autoimmune-associated neuroinflammation in a T cell-dependent manner. In: Journal of autoimmunity (Print), 124 (Art N° 102723). | - |
item.fulltext | With Fulltext | - |
item.validation | ecoom 2022 | - |
item.contributor | BOGIE, Jeroen | - |
item.contributor | VANMIERLO, Tim | - |
item.contributor | VANMOL, Jasmine | - |
item.contributor | TIMMERMANS, Silke | - |
item.contributor | MAILLEUX, Jo | - |
item.contributor | Wijnands, Erwin | - |
item.contributor | NELISSEN, Katherine | - |
item.contributor | Gustafsson, Jan-Ake | - |
item.contributor | STINISSEN, Piet | - |
item.contributor | WOUTERS, Kristiaan | - |
item.contributor | Steffensen, Knut R. | - |
item.contributor | Mulder, Monique | - |
item.contributor | Zelcer, Noam | - |
item.contributor | HENDRIKS, Jerome | - |
item.accessRights | Restricted Access | - |
crisitem.journal.issn | 0896-8411 | - |
crisitem.journal.eissn | 1095-9157 | - |
Appears in Collections: | Research publications |
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1-s2.0-S0896841121001311-main.pdf Restricted Access | Published version | 6.53 MB | Adobe PDF | View/Open Request a copy |
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