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http://hdl.handle.net/1942/35966
Title: | Probing intrahemispheric PMd – M1 interactions with a novel dual-site TMS setup | Authors: | HEHL, Melina Swinnen, Stephan CUYPERS, Koen |
Issue Date: | 2021 | Source: | Brain stimulation (Print), 14 (6) , p. 1633 -1634 | Abstract: | The net output of the primary motor cortex (M1) is shaped by several (non-)motor brain regions including the dorsal premotor cortex (PMd) which is playing an important role in sensorimotor integration, response selection, bimanual motor control, and motor learning. Previous dual-site transcranial magnetic stimulation (dsTMS) setups mainly investigated the interhemispheric PMd – M1 interactions, as testing the intrahemispheric PMd – M1 interactions yield technical difficulties due to the vicinity of both regions. A novel dsTMS setup was used in a sample of 23 young healthy right-handed adults to probe intrahemispheric left PMd – M1 interactions at rest. Biphasic stimuli were applied to M1 to elicit an MEP of at least 1 mV peak-to-peak amplitude (testing stimulus, TS) in the resting first dorsal interosseus (FDI). The conditioning stimulus (CS) was applied ∼2 cm anterior to M1 at an interstimulus interval (ISI) of 6 ms and an intensity of 75% of the resting motor threshold (rMT). To physiologically test this setup, short-interval intra-cortical inhibition (SICI) was measured with the same coil arrangement, using two coils targeted at M1 (ISI = 3 ms, CS intensity = 75% rMT, TS intensity = 1 mV). First, SICI could robustly be elicited using the novel coil setup. Second, conditioning left PMd lead to a robust modulation of left M1 output when using a CS intensity of 75% rMT. This interaction was mostly found to be inhibitory. However, in some subjects (∼15%) a facilitatory PMd – M1 interaction was seen. This novel coil setup opens new opportunities to measure intrahemispheric PMd – M1 interactions at rest and in different task-related contexts without facing technical difficulties such as large stimulation distances due to coil size or coil heating (particularly in small coils). | Keywords: | TMS;intrahemispheric;premotor cortex;connectivity | Document URI: | http://hdl.handle.net/1942/35966 | ISSN: | 1935-861X | e-ISSN: | 1876-4754 | DOI: | 10.1016/j.brs.2021.10.147 | Category: | M | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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1-s2.0-S1935861X21003934-main.pdf | Published version | 74.56 kB | Adobe PDF | View/Open |
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