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http://hdl.handle.net/1942/35976
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DC Field | Value | Language |
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dc.contributor.author | Bogaerts, E. | - |
dc.contributor.author | Ferdinande, B. | - |
dc.contributor.author | Palmers, P.J. | - |
dc.contributor.author | Malbrain, M. L. N. G. | - |
dc.contributor.author | Van Regenmortel, N. | - |
dc.contributor.author | Wilmer, A. | - |
dc.contributor.author | Lemmens, R. | - |
dc.contributor.author | Janssens, S. | - |
dc.contributor.author | NIJST, Petra | - |
dc.contributor.author | DE DEYNE, Cathy | - |
dc.contributor.author | Verhaert, D. | - |
dc.contributor.author | MULLENS, Wilfried | - |
dc.contributor.author | DENS, Jo | - |
dc.contributor.author | DUPONT, Matthias | - |
dc.contributor.author | AMELOOT, Koen | - |
dc.date.accessioned | 2021-11-30T15:03:39Z | - |
dc.date.available | 2021-11-30T15:03:39Z | - |
dc.date.issued | 2021 | - |
dc.date.submitted | 2021-10-28T11:37:30Z | - |
dc.identifier.citation | Resuscitation (London, Print), 168 , p. 1 -5 | - |
dc.identifier.issn | 2666-5204 | - |
dc.identifier.uri | http://hdl.handle.net/1942/35976 | - |
dc.description.abstract | Purpose: Fluid boluses (FB) are often used in post-cardiac arrest (CA) patients with haemodynamic instability. Although FB may improve cardiac output (CO) and mean arterial pressure (MAP), FB may also increase central venous pressure (CVP), reduce arterial PaO2, dilute haemoglobin and cause interstitial oedema. The aim of the present study was to investigate the net eect of FB administration on cerebral tissue oxygenation saturation (SctO(2)) in post-CA patients. Methods: Pre-planned sub-study of the Neuroprotect post-CA trial (NCT02541591). Patients with anticipated fluid responsiveness based on stroke volume variation (SVV) or passive leg raising test were administered a FB of 500 ml plasma-lyte A (Baxter Healthcare) and underwent pre- and post-FB assessments of stroke volume, CO, MAP, CVP, haemoglobin, PaO2 and SctO(2). Results: 52 patients (mean age 64 +/- 12 years, 75% male) received a total of 115 FB. Although administration of a FB resulted in a significant increase of stroke volume (63 +/- 22 vs 67 +/- 23 mL, p = 0.001), CO (4,2 +/- 1,6 vs 4,4 +/- 1,7 L/min, p = 0.001) and MAP (74,8 +/- 13,2 vs 79,2 +/- 12,9 mmHg, p = 0.004), it did not improve SctO(2) (68.54 +/- 6.99 vs 68.70 +/- 6.80%, p = 0.49). Fluid bolus administration also resulted in a significant increase of CVP (10,0 +/- 4,5 vs 10,7 +/- 4,9 mmHg, p = 0.02), but did not aect PaO2 (99 +/- 31 vs 94 +/- 31 mmHg, p = 0.15) or haemoglobin concentrations (12,9 +/- 2,1 vs 12,8 +/- 2,2 g/dL, p = 0.10). In a multivariate model, FB-induced changes in CO (beta 0,77; p = 0.004) and in CVP (beta-0,23; p = 0.02) but not in MAP (beta 0,02; p = 0.18) predicted post-FB DSctO(2). Conclusions: Despite improvements in CO and MAP, FB administration did not improve SctO(2) in post-cardiac arrest patients. | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.rights | 2021 Elsevier B.V. All rights reserved. | - |
dc.subject.other | Haemodynamic monitoring | - |
dc.subject.other | Cardiac arrest | - |
dc.subject.other | Fluid bolus | - |
dc.subject.other | Resuscitation | - |
dc.subject.other | Stroke volume variation | - |
dc.title | The effect of fluid bolus administration on cerebral tissue oxygenation in post-cardiac arrest patients | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 5 | - |
dc.identifier.spage | 1 | - |
dc.identifier.volume | 168 | - |
local.format.pages | 5 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Bogaerts, E (corresponding author), Univ Hosp Leuven, Dept Cardiovasc Dis, Leuven, Belgium. | - |
dc.description.notes | eline.bogaerts@uzleuven.be | - |
local.publisher.place | ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, | - |
local.publisher.place | IRELAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1016/j.resuscitation.2021.08.044 | - |
dc.identifier.pmid | 34506875 | - |
dc.identifier.isi | WOS:000703570500001 | - |
dc.identifier.eissn | 2666-5204 | - |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
local.description.affiliation | [Bogaerts, E.; Janssens, S.] Univ Hosp Leuven, Dept Cardiovasc Dis, Leuven, Belgium. | - |
local.description.affiliation | [Bogaerts, E.; Ferdinande, B.; Palmers, P. J.; Nijst, P.; Verhaert, D.; Mullens, W.; Dens, J.; Dupont, M.; Ameloot, K.] Ziekenhuis Oost Limburg, Dept Cardiol, Schiepse Bos 6, B-3600 Genk, Belgium. | - |
local.description.affiliation | [Malbrain, M. L. N. G.] Univ Hosp Brussels UZB, Intens Care Unit, Jette, Belgium. | - |
local.description.affiliation | [Malbrain, M. L. N. G.] Vrije Univ Brussel VUB, Fac Med & Pharm, Brussels, Belgium. | - |
local.description.affiliation | [Van Regenmortel, N.; Ameloot, K.] Ziekenhuisnetwerk Antwerpen, Dept Intens Care Med, Campus Stuivenberg, Antwerp, Belgium. | - |
local.description.affiliation | [Wilmer, A.] Univ Hosp Leuven, Med Intens Care Unit, Leuven, Belgium. | - |
local.description.affiliation | [Lemmens, R.] Univ Hosp Leuven, Dept Neurol, Leuven, Belgium. | - |
local.description.affiliation | [De Deyne, C.; Mullens, W.; Dens, J.; Dupont, M.; Ameloot, K.] Univ Hasselt, Fac Med & Life Sci, Diepenbeek, Belgium. | - |
local.description.affiliation | [De Deyne, C.] Ziekenhuis Oost Limburg, Dept Anesthesiol & Crit Care Med, Genk, Belgium. | - |
local.uhasselt.international | no | - |
item.fulltext | With Fulltext | - |
item.contributor | Bogaerts, E. | - |
item.contributor | Ferdinande, B. | - |
item.contributor | Palmers, P.J. | - |
item.contributor | Malbrain, M. L. N. G. | - |
item.contributor | Van Regenmortel, N. | - |
item.contributor | Wilmer, A. | - |
item.contributor | Lemmens, R. | - |
item.contributor | Janssens, S. | - |
item.contributor | NIJST, Petra | - |
item.contributor | DE DEYNE, Cathy | - |
item.contributor | Verhaert, D. | - |
item.contributor | MULLENS, Wilfried | - |
item.contributor | DENS, Jo | - |
item.contributor | DUPONT, Matthias | - |
item.contributor | AMELOOT, Koen | - |
item.validation | ecoom 2022 | - |
item.fullcitation | Bogaerts, E.; Ferdinande, B.; Palmers, P.J.; Malbrain, M. L. N. G.; Van Regenmortel, N.; Wilmer, A.; Lemmens, R.; Janssens, S.; NIJST, Petra; DE DEYNE, Cathy; Verhaert, D.; MULLENS, Wilfried; DENS, Jo; DUPONT, Matthias & AMELOOT, Koen (2021) The effect of fluid bolus administration on cerebral tissue oxygenation in post-cardiac arrest patients. In: Resuscitation (London, Print), 168 , p. 1 -5. | - |
item.accessRights | Restricted Access | - |
crisitem.journal.issn | 0300-9572 | - |
crisitem.journal.eissn | 1873-1570 | - |
Appears in Collections: | Research publications |
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1-s2.0-S0300957221003476-main.pdf Restricted Access | Published version | 467.14 kB | Adobe PDF | View/Open Request a copy |
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