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http://hdl.handle.net/1942/35979
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DC Field | Value | Language |
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dc.contributor.author | MUNUSWAMY, Revathy | - |
dc.contributor.author | Derave, Wim | - |
dc.contributor.author | DE BRANDT, Jana | - |
dc.contributor.author | BURTIN, Chris | - |
dc.contributor.author | AUMANN, Joseph | - |
dc.contributor.author | SPRUIT, Martijn A. | - |
dc.contributor.author | MICHIELS, Luc | - |
dc.date.accessioned | 2021-11-30T15:19:26Z | - |
dc.date.available | 2021-11-30T15:19:26Z | - |
dc.date.issued | 2021 | - |
dc.date.submitted | 2021-10-28T11:32:46Z | - |
dc.identifier.citation | JOURNAL OF INFLAMMATION RESEARCH, 14 , p. 4503 -4507 | - |
dc.identifier.uri | http://hdl.handle.net/1942/35979 | - |
dc.description.abstract | Chronic low-grade systemic inflammation is frequently observed in patients with chronic obstructive pulmonary disease (COPD), e.g., elevated pentameric CRP (pCRP). However, pCRP can dissociate to form monomeric CRP (mCRP) which exhibits a clear pro inflammatory behaviour in contrast to the more anti-inflammatory properties of pCRP. Therefore, mCRP may be an informative biomarker to demonstrate chronic low-grade systemic inflammation. This was confirmed by analysing serum samples from 38 patients with COPD and 18 non-COPD control persons (NCCP). mCRP was significantly elevated in patients with COPD vs. NCCP, indicating that mCRP might be considered as a new sensitive marker of chronic low-grade systemic inflammation. | - |
dc.description.sponsorship | De Brandt J. is funded by the Flemish government. The Research of FWO Aspirant De Brandt J. is sponsored by FWO-grant #11B4718N. Burtin C. is funded by Limburgs Kankerfonds. The authors acknowledge Ms. Bogaers A. of Hasselt University (Diepenbeek, Belgium) for performing blood sampling and DXA scanning. The UBiLim (University Biobank Limburg; Belgium) is acknowledged as they provided storage and release of all human biological material used in this publication. (Linsen L. et al., Raising to the Challenge: Building a Federated Biobank to Accelerate Translational Research-The University Biobank Limburg. Front Med (Lausanne), 2019. 6: p. 224.) | - |
dc.language.iso | en | - |
dc.publisher | DOVE MEDICAL PRESS LTD | - |
dc.rights | 2021 Munuswamy et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/ terms.php and incorporate the Creative Commons Attribution – | - |
dc.subject.other | COPD | - |
dc.subject.other | Dlow-grade systemic inflammation | - |
dc.subject.other | pCRP | - |
dc.subject.other | mCRP | - |
dc.title | Monomeric CRP is Elevated in Patients with COPD Compared to Non-COPD Control Persons | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 4507 | - |
dc.identifier.spage | 4503 | - |
dc.identifier.volume | 14 | - |
local.format.pages | 5 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Michiels, L (corresponding author), Hasselt Univ, Biomed Res Inst BIOMED, Fac Med & Life Sci, Hasselt, Belgium. | - |
dc.description.notes | luc.michiels@uhasselt.be | - |
local.publisher.place | PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Letter | - |
dc.identifier.doi | 10.2147/JIR.S320659 | - |
dc.identifier.pmid | 34522118 | - |
dc.identifier.isi | WOS:000703153600005 | - |
dc.identifier.eissn | 1178-7031 | - |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
local.description.affiliation | [Munuswamy, Revathy; Michiels, Luc] Hasselt Univ, Biomed Res Inst BIOMED, Fac Med & Life Sci, Hasselt, Belgium. | - |
local.description.affiliation | [De Brandt, Jana; Burtin, Chris] Hasselt Univ, Biomed Res Inst BIOMED, Fac Rehabil Sci, Rehabil Res Ctr REVAL, Hasselt, Belgium. | - |
local.description.affiliation | [Derave, Wim] Univ Ghent, Dept Movement & Sports Sci, Ghent, Belgium. | - |
local.description.affiliation | [Aumann, Joseph] Jessa Hosp, Dept Pneumol, Hasselt, Belgium. | - |
local.description.affiliation | [Spruit, Martijn A.] CIRO, Dept Res & Dev, Horn, Netherlands. | - |
local.description.affiliation | [Spruit, Martijn A.] Maastricht Univ, Med Ctr, NUTRIM Sch Nutr & Translat Res Metab, Fac Hlth Med & Life Sci,Dept Resp Med, Maastricht, Netherlands. | - |
local.uhasselt.international | yes | - |
item.fulltext | With Fulltext | - |
item.accessRights | Open Access | - |
item.contributor | MUNUSWAMY, Revathy | - |
item.contributor | Derave, Wim | - |
item.contributor | DE BRANDT, Jana | - |
item.contributor | BURTIN, Chris | - |
item.contributor | AUMANN, Joseph | - |
item.contributor | SPRUIT, Martijn A. | - |
item.contributor | MICHIELS, Luc | - |
item.fullcitation | MUNUSWAMY, Revathy; Derave, Wim; DE BRANDT, Jana; BURTIN, Chris; AUMANN, Joseph; SPRUIT, Martijn A. & MICHIELS, Luc (2021) Monomeric CRP is Elevated in Patients with COPD Compared to Non-COPD Control Persons. In: JOURNAL OF INFLAMMATION RESEARCH, 14 , p. 4503 -4507. | - |
item.validation | ecoom 2022 | - |
crisitem.journal.issn | 1178-7031 | - |
crisitem.journal.eissn | 1178-7031 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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JIR_A_320659 4503..4507.pdf | Published version | 1.47 MB | Adobe PDF | View/Open |
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