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http://hdl.handle.net/1942/35980
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DC Field | Value | Language |
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dc.contributor.author | DE BRANDT, Jana | - |
dc.contributor.author | BURTIN, Chris | - |
dc.contributor.author | Pomies, P. | - |
dc.contributor.author | VANDENABEELE, Frank | - |
dc.contributor.author | VERBOVEN, Kenneth | - |
dc.contributor.author | AUMANN, Joseph | - |
dc.contributor.author | Blancquaert, L. | - |
dc.contributor.author | Everaert, I | - |
dc.contributor.author | VAN RYCKEGHEM, Lisa | - |
dc.contributor.author | COPS, Jirka | - |
dc.contributor.author | Hayot, M. | - |
dc.contributor.author | SPRUIT, Martijn A. | - |
dc.contributor.author | Derave, W. | - |
dc.date.accessioned | 2021-11-30T15:46:24Z | - |
dc.date.available | 2021-11-30T15:46:24Z | - |
dc.date.issued | 2021 | - |
dc.date.submitted | 2021-10-28T11:22:58Z | - |
dc.identifier.citation | JOURNAL OF APPLIED PHYSIOLOGY, 131 (4) , p. 1230 -1240 | - |
dc.identifier.uri | http://hdl.handle.net/1942/35980 | - |
dc.description.abstract | Oxidative/carbonyl stress is elevated in lower-limb muscles of patients with chronic obstructive pulmonary disease (COPD). Carnosine is a skeletal muscle antioxidant particularly present in fast-twitch fibers. The aims of the present study were to compare muscle carnosine, oxidative/carbonyl stress, antioxidants, and fiber characteristics between patients with COPD and healthy controls (HCs) and between patients after stratification for airflow limitation (mild/moderate vs. severe/very severe), as well as to investigate correlates of carnosine in patients with COPD. A vastus lateralis muscle biopsy was obtained from 40 patients with stable COPD and 20 age- and sex-matched HCs. Carnosine, oxidative/carbonyl stress, antioxidants, fiber characteristics, quadriceps strength and endurance (QE), V(O2)peak (incremental cycle test), and physical activity (PA) were determined. Patients with COPD had a similar carnosine concentration [4.16mmol/kg wet weight (WW; SD = 1.93)] to HCs [4.64mmol/kg WW (SD = 1.71)] and significantly higher percentage of fast-twitch fibers and lower QE, V(O2)peak, and PA versus HCs. Patients with severe/very severe COPD had a 31% lower carnosine concentration [3.24mmol/kg WW (SD = 1.79); n = 15] versus patients with mild/moderate COPD [4.71mmol/kg WW (SD = 1.83); n = 25; P = 0.02] and significantly lower V(O2)peak and PA versus patients with mild/moderate COPD. Carnosine correlated significantly with QE (r(s) = 0.427), V(O2)peak (r(s) = 0.334), PA (r(s) = 0.379), and lung function parameters in patients with COPD. In conclusion, despite having the highest proportion of fast-twitch fibers, patients with severe/very severe COPD displayed a 31% lower muscle carnosine concentration compared with patients with mild/moderate COPD. As no other markers of oxidative/carbonyl stress or antioxidants were affected, the observed carnosine deficiency is thought to be a possible first sign of muscle redox balance abnormalities. NEW & NOTEWORTHY Carnosine, particularly present in fast-twitch fibers, was investigated in the quadriceps of patients with chronic obstructive pulmonary disease (COPD). Carnosine concentration was similar between patients with COPD and healthy controls but was 31% lower in patients with severe/very severe COPD, despite their high proportion of fast-twitch fibers, versus patients with mild/moderate COPD. As no other markers of oxidative/carbonyl stress or antioxidants were affected, the observed carnosine deficiency is thought to be a possible first sign of muscle redox balance abnormalities. | - |
dc.description.sponsorship | Flemish GovernmentEuropean Commission; FWOFWO [11B4718N]; Limburgs Kankerfonds | - |
dc.language.iso | en | - |
dc.publisher | AMER PHYSIOLOGICAL SOC | - |
dc.subject.other | carbonyl stress; carnosine; chronic obstructive pulmonary disease; | - |
dc.subject.other | oxidative stress; quadriceps | - |
dc.title | Carnosine, oxidative and carbonyl stress, antioxidants, and muscle fiber characteristics of quadriceps muscle of patients with COPD | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 1240 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 1230 | - |
dc.identifier.volume | 131 | - |
local.format.pages | 11 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Burtin, C (corresponding author), Hasselt Univ, Fac Rehabil Sci, REVAL Rehabil Res Ctr, Diepenbeek, Belgium.; Burtin, C (corresponding author), Hasselt Univ, Fac Med & Life Sci, BIOMED Biomed Res Inst, Diepenbeek, Belgium. | - |
dc.description.notes | chris.burtin@uhasselt.be | - |
local.publisher.place | 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1152/japplphysiol.00200.2021 | - |
dc.identifier.isi | WOS:000702916400001 | - |
dc.contributor.orcid | De Brandt, Jana/0000-0003-3463-1911; Pomies, Pascal/0000-0002-5301-6087 | - |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
local.description.affiliation | [De Brandt, J.; Burtin, C.; Vandenabeele, F.; Verboven, K.; Van Ryckeghem, L.; Cops, J.] Hasselt Univ, Fac Rehabil Sci, REVAL Rehabil Res Ctr, Diepenbeek, Belgium. | - |
local.description.affiliation | [De Brandt, J.; Burtin, C.; Verboven, K.; Van Ryckeghem, L.; Cops, J.] Hasselt Univ, Fac Med & Life Sci, BIOMED Biomed Res Inst, Diepenbeek, Belgium. | - |
local.description.affiliation | [Pomies, P.; Hayot, M.] Univ Montpellier, PhyMedExp, INSERM, CNRS,CHRU Montpellier, Montpellier, France. | - |
local.description.affiliation | [Aumann, J.] Jessa Hosp, Dept Resp Med, Hasselt, Belgium. | - |
local.description.affiliation | [Blancquaert, L.; Everaert, I; Derave, W.] Univ Ghent, Dept Movement & Sports Sci, Ghent, Belgium. | - |
local.description.affiliation | [Spruit, M. A.] CIRO, Dept Res & Dev, Horn, Netherlands. | - |
local.description.affiliation | [Spruit, M. A.] Maastricht Univ, Med Ctr, Dept Resp Med, Maastricht, Netherlands. | - |
local.description.affiliation | [Spruit, M. A.] Maastricht Univ, Med Ctr, Fac Hlth Med & Life Sci, NUTRIM Sch Nutr & Translat Res Metab, Maastricht, Netherlands. | - |
local.uhasselt.international | yes | - |
item.contributor | DE BRANDT, Jana | - |
item.contributor | BURTIN, Chris | - |
item.contributor | Pomies, P. | - |
item.contributor | VANDENABEELE, Frank | - |
item.contributor | VERBOVEN, Kenneth | - |
item.contributor | AUMANN, Joseph | - |
item.contributor | Blancquaert, L. | - |
item.contributor | Everaert, I | - |
item.contributor | VAN RYCKEGHEM, Lisa | - |
item.contributor | COPS, Jirka | - |
item.contributor | Hayot, M. | - |
item.contributor | SPRUIT, Martijn A. | - |
item.contributor | Derave, W. | - |
item.accessRights | Closed Access | - |
item.fullcitation | DE BRANDT, Jana; BURTIN, Chris; Pomies, P.; VANDENABEELE, Frank; VERBOVEN, Kenneth; AUMANN, Joseph; Blancquaert, L.; Everaert, I; VAN RYCKEGHEM, Lisa; COPS, Jirka; Hayot, M.; SPRUIT, Martijn A. & Derave, W. (2021) Carnosine, oxidative and carbonyl stress, antioxidants, and muscle fiber characteristics of quadriceps muscle of patients with COPD. In: JOURNAL OF APPLIED PHYSIOLOGY, 131 (4) , p. 1230 -1240. | - |
item.fulltext | No Fulltext | - |
item.validation | ecoom 2022 | - |
crisitem.journal.issn | 8750-7587 | - |
crisitem.journal.eissn | 1522-1601 | - |
Appears in Collections: | Research publications |
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