Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/35992
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DC Field | Value | Language |
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dc.contributor.author | D'Hollander, Antoine | - |
dc.contributor.author | Van Roosbroeck, Ruben | - |
dc.contributor.author | Trekker, Jesse | - |
dc.contributor.author | Stakenborg, Tim | - |
dc.contributor.author | Dresselaers, Tom | - |
dc.contributor.author | Vande Velde, Greetje | - |
dc.contributor.author | STRUYS, Tom | - |
dc.contributor.author | LAMBRICHTS, Ivo | - |
dc.contributor.author | Lammertyn, Jeroen | - |
dc.contributor.author | Lagae, Liesbet | - |
dc.contributor.author | Himmelreich, Uwe | - |
dc.date.accessioned | 2021-12-01T09:48:13Z | - |
dc.date.available | 2021-12-01T09:48:13Z | - |
dc.date.issued | 2021 | - |
dc.date.submitted | 2021-10-28T13:10:09Z | - |
dc.identifier.citation | PHARMACEUTICS, 13 (9) ,(Art N° 1494) | - |
dc.identifier.issn | 1999-4923 | - |
dc.identifier.uri | http://hdl.handle.net/1942/35992 | - |
dc.description.abstract | The use of multimodal contrast agents can potentially overcome the intrinsic limitations of individual imaging methods. We have validated synthetic antiferromagnetic nanoparticles (SAF-NPs) as bimodal contrast agents for in vitro cell labeling and in vivo cell tracking using magnetic resonance imaging (MRI) and computed tomography (CT). SAF-NP-labeled cells showed high contrast in MRI phantom studies (r(2)* = 712 s(-1) mM(-1)), while pelleted cells showed clear contrast enhancement in CT. After intravenous SAF-NP injection, nanoparticles accumulated in the liver and spleen, as visualized in vivo by significant MRI contrast enhancement. Intravenous injection of SAF-NP-labeled cells resulted in cell accumulation in the lungs, which was clearly detectable by using CT but not by using MRI. SAF-NPs proved to be very efficient cell labeling agents for complementary MRI- and CT-based cell tracking. Bimodal monitoring of SAF-NP labeled cells is in particular of interest for applications where the applied imaging methods are not able to visualize the particles and/or cells in all organs. | - |
dc.description.sponsorship | agency for Innovation by Science and Technology IWT 080017 IWT 140061 European Commission European Commission Joint Research Centre H2020_FET-OPEN-766456 H2020-NMP-2015-686009 FP7-NMP-2008-228933 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.rights | Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). | - |
dc.subject.other | magnetic resonance imaging; MRI; computed tomography; CT; | - |
dc.subject.other | antiferromagnetic nanoparticles; gold nanoparticles; top down synthesis; | - |
dc.subject.other | bimodal contrast agent | - |
dc.title | Synthetic Antiferromagnetic Gold Nanoparticles as Bimodal Contrast Agents in MRI and CT—An Experimental In Vitro and In Vivo Study | - |
dc.type | Journal Contribution | - |
dc.identifier.issue | 9 | - |
dc.identifier.spage | 1494 | - |
dc.identifier.volume | 13 | - |
local.format.pages | 17 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Himmelreich, U (corresponding author), Katholieke Univ Leuven, Biomed MRI Unit, Dept Imaging & Pathol, O&N 1,Herestr 49, B-3000 Leuven, Belgium.; Himmelreich, U (corresponding author), IMEC, Dept Life Sci Technol, Kapeldreef 75, B-3001 Leuven, Belgium. | - |
dc.description.notes | antoinedhollander@hotmail.com; ruben.vanroosbroeck@gmail.com; | - |
dc.description.notes | jessetrekker@gmail.com; Tim.Stakenborg@imec.be; | - |
dc.description.notes | tom.dresselaers@uzleuven.be; Greetje.Vandevelde@kuleuven.be; | - |
dc.description.notes | tom.struys@sprofit.com; ivo.lambrichts@uhasselt.be; | - |
dc.description.notes | jeroen.lammertyn@kuleuven.be; liesbet.lagae@imec.be; | - |
dc.description.notes | uwe.himmelreich@kuleuven.be | - |
local.publisher.place | ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 1494 | - |
dc.identifier.doi | 10.3390/pharmaceutics13091494 | - |
dc.identifier.isi | 000701471400001 | - |
dc.contributor.orcid | Himmelreich, Uwe/0000-0002-2060-8895; Vande Velde, | - |
dc.contributor.orcid | Greetje/0000-0002-5633-3993; Lammertyn, jeroen/0000-0001-8143-6794 | - |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
local.description.affiliation | [D'Hollander, Antoine; Trekker, Jesse; Dresselaers, Tom; Vande Velde, Greetje; Himmelreich, Uwe] Katholieke Univ Leuven, Biomed MRI Unit, Dept Imaging & Pathol, O&N 1,Herestr 49, B-3000 Leuven, Belgium. | - |
local.description.affiliation | [D'Hollander, Antoine; Van Roosbroeck, Ruben; Trekker, Jesse; Stakenborg, Tim; Lagae, Liesbet; Himmelreich, Uwe] IMEC, Dept Life Sci Technol, Kapeldreef 75, B-3001 Leuven, Belgium. | - |
local.description.affiliation | [Van Roosbroeck, Ruben] Katholieke Univ Leuven, Div Mechatron, Dept Biosyst Biostat & Sensors, B-3001 Leuven, Belgium. | - |
local.description.affiliation | [Struys, Tom; Lambrichts, Ivo] Hasselt Univ, Histol Lab, Biomed Res Inst, Agora Laan Gebouw C, B-3590 Diepenbeek, Belgium. | - |
local.description.affiliation | [Lagae, Liesbet] Katholieke Univ Leuven, Dept Phys, Fac Sci, Lab Soft Matter & Biophys, Celestijnenlaan 200D, B-3001 Leuven, Belgium. | - |
local.uhasselt.international | no | - |
item.validation | ecoom 2022 | - |
item.contributor | D'Hollander, Antoine | - |
item.contributor | Van Roosbroeck, Ruben | - |
item.contributor | Trekker, Jesse | - |
item.contributor | Stakenborg, Tim | - |
item.contributor | Dresselaers, Tom | - |
item.contributor | Vande Velde, Greetje | - |
item.contributor | STRUYS, Tom | - |
item.contributor | LAMBRICHTS, Ivo | - |
item.contributor | Lammertyn, Jeroen | - |
item.contributor | Lagae, Liesbet | - |
item.contributor | Himmelreich, Uwe | - |
item.accessRights | Open Access | - |
item.fullcitation | D'Hollander, Antoine; Van Roosbroeck, Ruben; Trekker, Jesse; Stakenborg, Tim; Dresselaers, Tom; Vande Velde, Greetje; STRUYS, Tom; LAMBRICHTS, Ivo; Lammertyn, Jeroen; Lagae, Liesbet & Himmelreich, Uwe (2021) Synthetic Antiferromagnetic Gold Nanoparticles as Bimodal Contrast Agents in MRI and CT—An Experimental In Vitro and In Vivo Study. In: PHARMACEUTICS, 13 (9) ,(Art N° 1494). | - |
item.fulltext | With Fulltext | - |
crisitem.journal.eissn | 1999-4923 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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pharmaceutics-13-01494.pdf | Published version | 5.52 MB | Adobe PDF | View/Open |
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