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http://hdl.handle.net/1942/36027
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DC Field | Value | Language |
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dc.contributor.author | Li, N. | - |
dc.contributor.author | van Oostwaard, M. | - |
dc.contributor.author | VAN DEN BERGH, Joop | - |
dc.contributor.author | Hiligsmann, M. | - |
dc.contributor.author | Boonen, A. | - |
dc.contributor.author | van Kuijk, S. M. J. | - |
dc.contributor.author | Vranken, L. | - |
dc.contributor.author | Bours, S. P. G. | - |
dc.contributor.author | Wyers, C.E. | - |
dc.date.accessioned | 2021-12-02T19:38:29Z | - |
dc.date.available | 2021-12-02T19:38:29Z | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2021-11-05T13:21:23Z | - |
dc.identifier.citation | Osteoporosis international, 33 (3) , p. 577-588 | - |
dc.identifier.issn | 0937-941X | - |
dc.identifier.uri | http://hdl.handle.net/1942/36027 | - |
dc.description.abstract | This study explored the course of health state utility value over 3 years in patients with a recent fracture attending a Fracture Liaison Service and suggested that the overall change in health-related quality of life was not significant, although significant improvements were observed at 6 and 12 months compared to baseline. Introduction To estimate the 3-year health-related quality of life (HRQoL) of patients with a recent fracture presenting at a Fracture Liaison Service (FLS) and to explore factors associated with health state utility value (HSUV). Methods Patients' HSUVs were derived from the EQ-5D-5L and SF-6D and calculated at six time points. Multiple imputation was applied for missing data. Linear mixed-effects regression analysis with random intercept and slope was applied to explore the course of HSUV over 3 years. The impact of subsequent fracture and the length of time between FLS visit and patients' index fracture on HSUV were also investigated. A backward stepwise elimination was applied to identify factors associated with HSUV. Results A total of 499 patients were included. The change of EQ-5D HSUV was not significant over 3-year follow-up (P = 0.52), although slightly but significantly higher HSUV was captured at 6 months (mean difference (MD): 0.015, P = 0.02) and 12 months (MD: 0.018, P = 0.01). There was no significant difference in the course of EQ-5D HSUV between fracture locations (P = 0.86). A significant increase in HSUV was only captured for patients had shorter time period (< 107 days) between FLS visit and their index fracture. Suffering a subsequent fracture was associated with significant QoL loss (MD: - 0.078, P < 0.001). Subsequent fracture, previous treatment with anti-osteoporosis medication, a prevalent vertebral fracture (grade 2 or 3), use of a walking aid, previous falls, and higher BMI were negatively associated with mean EQ-5D HSUV over 3 years. Comparable results were found using SF-6D HSUV. The lack of HRQoL data immediately after fracture and selection bias were two main limitations. Conclusion The 3-year change in HSUV was not statistically significant, although significant improvements were observed at 6 and 12 months in comparison with baseline. Six factors were negatively associated with EQ-5D HSUV. | - |
dc.description.sponsorship | China Scholarship CouncilChina Scholarship Council [201909110080] | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER LONDON LTD | - |
dc.rights | The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attri bution-NonCommercial 4.0 International License | - |
dc.subject.other | EQ-5D-5L | - |
dc.subject.other | Health utility | - |
dc.subject.other | Longitudinal analysis | - |
dc.subject.other | SF-6D | - |
dc.title | Health-related quality of life of patients with a recent fracture attending a fracture liaison service: a 3-year follow-up study | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 588 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 577 | - |
dc.identifier.volume | 33 | - |
local.format.pages | 12 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Li, N (corresponding author), Maastricht Univ, CAPHRI Care Publ Hlth Res Inst, Dept Hlth Serv Res, POB 616, NL-6200 MD Maastricht, Netherlands. | - |
dc.description.notes | n.li@maastrichtuniversity.nl | - |
local.publisher.place | 236 GRAYS INN RD, 6TH FLOOR, LONDON WC1X 8HL, ENGLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1007/s00198-021-06204-x | - |
dc.identifier.isi | 000709218000001 | - |
dc.identifier.eissn | 1433-2965 | - |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
local.description.affiliation | [Li, N.; Hiligsmann, M.] Maastricht Univ, CAPHRI Care Publ Hlth Res Inst, Dept Hlth Serv Res, POB 616, NL-6200 MD Maastricht, Netherlands. | - |
local.description.affiliation | [van Oostwaard, M.; van den Bergh, J. P.; Vranken, L.; Wyers, C. E.] VieCuri, Dept Internal Med, Med Ctr, Venlo, Netherlands. | - |
local.description.affiliation | [van Oostwaard, M.; van den Bergh, J. P.; Vranken, L.; Wyers, C. E.] Maastricht Univ, Dept Internal Med, Med Ctr, Maastricht, Netherlands. | - |
local.description.affiliation | [van Oostwaard, M.; van den Bergh, J. P.; Vranken, L.; Wyers, C. E.] Maastricht Univ, NUTRIM Res Inst, Med Ctr, Maastricht, Netherlands. | - |
local.description.affiliation | [van Oostwaard, M.] Hasselt Univ, Fac Med, Hasselt, Belgium. | - |
local.description.affiliation | [Boonen, A.; Bours, S. P. G.] Maastricht Univ, Med Ctr, Div Rheumatol, Dept Internal Med, Maastricht, Netherlands. | - |
local.description.affiliation | [van Kuijk, S. M. J.] Maastricht Univ, CAPHRI Res Inst, Maastricht, Netherlands. | - |
local.description.affiliation | [van Kuijk, S. M. J.] Maastricht Univ, Med Ctr, Dept Clin Epidemiol & Med Technol Assessment, Maastricht, Netherlands. | - |
local.uhasselt.international | yes | - |
item.validation | ecoom 2022 | - |
item.fullcitation | Li, N.; van Oostwaard, M.; VAN DEN BERGH, Joop; Hiligsmann, M.; Boonen, A.; van Kuijk, S. M. J.; Vranken, L.; Bours, S. P. G. & Wyers, C.E. (2022) Health-related quality of life of patients with a recent fracture attending a fracture liaison service: a 3-year follow-up study. In: Osteoporosis international, 33 (3) , p. 577-588. | - |
item.accessRights | Open Access | - |
item.fulltext | With Fulltext | - |
item.contributor | Li, N. | - |
item.contributor | van Oostwaard, M. | - |
item.contributor | VAN DEN BERGH, Joop | - |
item.contributor | Hiligsmann, M. | - |
item.contributor | Boonen, A. | - |
item.contributor | van Kuijk, S. M. J. | - |
item.contributor | Vranken, L. | - |
item.contributor | Bours, S. P. G. | - |
item.contributor | Wyers, C.E. | - |
crisitem.journal.issn | 0937-941X | - |
crisitem.journal.eissn | 1433-2965 | - |
Appears in Collections: | Research publications |
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s00198-021-06204-x.pdf | Published version | 691.68 kB | Adobe PDF | View/Open |
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