Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/36028
Title: | Incidence, hospitalization and mortality and their changes over time in people with a first ever diabetic foot ulcer | Authors: | Roikjer, Johan Werkman, Nikki C. C. Ejskjaer, Niels VAN DEN BERGH, Joop Vestergaard, Peter Schaper, Nicolaas C. Jensen, Morten Hasselstrom Klungel, Olaf de Vries, Frank Nielen, Johannes T. H. Driessen, Johanna H. M. |
Issue Date: | 2022 | Publisher: | WILEY | Source: | DIABETIC MEDICINE, 39 (4) (Art N° e14725) | Abstract: | Aims A diabetic foot ulcer (DFU) is a severe condition associated with morbidity and mortality. Population-based studies are rare and limited by access to reliable data. Without this data, efforts in primary prevention cannot be evaluated. Therefore, we examined the incidence and changes over time for the first DFU in people with diabetes. We also examined hospitalization and all-cause mortality and their changes over time. Methods From the UK primary care CPRD GOLD database (2007-2017), we identified 129,624 people with diabetes by a prescription for insulin or a non-insulin anti-diabetic drug. DFUs were identified using Read codes and expressed as incidence rates (IRs). Changes over time were described using Poisson and logistic regression and expressed as incidence rate ratios (IRRs) and odds ratios (ORs) respectively. Results The mean IR of first registered DFUs was 2.5 [95% CI: 2.1-2.9] per 1000 person-years for people with type 2 diabetes and 1.6 [1.3-1.9] per 1000 person-years for people with type 1. The IRs declined for people with type 2 diabetes (IRR per year: 0.97 [0.96-0.99]), while no changes were observed for people with type 1 diabetes (IRR per year: 0.96 [0.89-1.04]). Average hospitalization and 1-year mortality risk for people with type 2 diabetes were 8.2% [SD: 4.7] and 11.7% [SD: 2.2] respectively. Both declined over time (OR: 0.89 [0.84, 0.94] and 0.94 [0.89, 0.99]). Conclusion The decline in all IRs, hospitalizations and mortality in people with type 2 diabetes suggests that prevention and care of the first DFU has improved for this group in primary care in the UK. | Notes: | de Vries, F (corresponding author), Univ Utrecht, Utrecht Inst Pharmaceut Sci, Div Pharmacoepidemiol & Clin Pharmacol, Utrecht, Netherlands. f.devries@uu.nl |
Keywords: | diabetes mellitus;diabetic foot disease;diabetic foot ulcer;hospitalization;mortality | Document URI: | http://hdl.handle.net/1942/36028 | ISSN: | 0742-3071 | e-ISSN: | 1464-5491 | DOI: | 10.1111/dme.14725 | ISI #: | 000709871000001 | Rights: | 2021 Diabetes UK | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2022 |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
dme.14725.pdf Restricted Access | Published version | 278.1 kB | Adobe PDF | View/Open Request a copy |
WEB OF SCIENCETM
Citations
9
checked on Sep 27, 2024
Page view(s)
34
checked on Sep 7, 2022
Download(s)
4
checked on Sep 7, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.