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http://hdl.handle.net/1942/36031
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DC Field | Value | Language |
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dc.contributor.author | Monien, Bernhard H. | - |
dc.contributor.author | Bergau, Nick | - |
dc.contributor.author | HOGERVORST, Janneke | - |
dc.contributor.author | NAWROT, Tim | - |
dc.contributor.author | Trefflich, Iris | - |
dc.contributor.author | Weikert, Cornelia | - |
dc.contributor.author | Abraham, Klaus | - |
dc.date.accessioned | 2021-12-03T14:32:13Z | - |
dc.date.available | 2021-12-03T14:32:13Z | - |
dc.date.issued | 2021 | - |
dc.date.submitted | 2021-11-23T16:31:28Z | - |
dc.identifier.citation | MOLECULAR NUTRITION & FOOD RESEARCH, 65(23), (Art N° 2100584) | - |
dc.identifier.issn | 1613-4125 | - |
dc.identifier.uri | http://hdl.handle.net/1942/36031 | - |
dc.description.abstract | Scope Furfuryl alcohol is a heat-induced food contaminant, classified as possibly carcinogenic to humans. The proximal carcinogen 2-sulfoxymethylfuran leads to adduct formation in DNA and proteins (e.g., N-((furan-2-yl)methyl)-Val (FFA-Val) in hemoglobin). Methods and results This study analyzed human erythrocyte samples from two studies for the presence of FFA-Val: the Risks and Benefits of a Vegan Diet study (RBVD; 72 adults) and the ENVIRonmental influence ON early AGEing birth cohort study (ENVIRONAGE; 100 mother-newborn pairs). In the RBVD study, FFA-Val levels are lower in vegans compared to omnivores (median 13.0 vs 15.8 pmol g(-1) hemoglobin, p = 0.008), and lower in non-smokers compared to smokers (median 14.1 vs 17.0 pmol g(-1) hemoglobin, p = 0.003). In the birth cohort, FFA-Val levels are distinctly higher in maternal compared to newborn samples (median 15.2 vs 2.2 pmol g(-1) hemoglobin, p < 0.001). Conclusions FFA-Val, hitherto detected only in blood samples of mice, is quantifiable in all human samples, indicating a general exposure to furfuryl alcohol. The low adduct levels in blood samples from newborn children suggested that the placenta is a barrier to furfuryl alcohol. Dietary habits and tobacco smoking are two main influencing factors on the formation of FFA-Val, which may be of use as a biomarker of exposure to furfuryl alcohol. | - |
dc.description.sponsorship | European Research Council (ERC) European Commission ERC-2012-StG310898 FWO 273 1516112N/G.0873.11.N.10 12J9516N | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.rights | © 2021 The Authors. Molecular Nutrition & Food Research published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, | - |
dc.subject.other | birth cohort; coffee; cord blood; furfuryl alcohol; hemoglobin adducts; | - |
dc.subject.other | vegan diet | - |
dc.title | Detection of a Hemoglobin Adduct of the Food Contaminant Furfuryl Alcohol in Humans: Levels of N-((Furan-2-yl)methyl)-valine in Two Epidemiological Studies | - |
dc.type | Journal Contribution | - |
dc.identifier.issue | 23 | - |
dc.identifier.volume | 65 | - |
local.format.pages | 7 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Monien, BH (corresponding author), German Fed Inst Risk Assessment BfR, Dept Food Safety, Max Dohrn Str 8-10, D-10589 Berlin, Germany. | - |
dc.description.notes | bernhard.monien@bfr.bund.de | - |
local.publisher.place | 111 RIVER ST, HOBOKEN 07030-5774, NJ USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 2100584 | - |
dc.identifier.doi | 10.1002/mnfr.202100584 | - |
dc.identifier.isi | 000713103100001 | - |
dc.contributor.orcid | Abraham, Klaus/0000-0003-1895-9909 | - |
dc.identifier.eissn | 1613-4133 | - |
local.provider.type | wosris | - |
local.uhasselt.uhpub | yes | - |
local.description.affiliation | [Monien, Bernhard H.; Bergau, Nick; Trefflich, Iris; Weikert, Cornelia; Abraham, Klaus] German Fed Inst Risk Assessment BfR, Dept Food Safety, Max Dohrn Str 8-10, D-10589 Berlin, Germany. | - |
local.description.affiliation | [Hogervorst, Janneke G. F.; Nawrot, Tim S.] Hasselt Univ, Ctr Environm Sci, Agoralaan Gebouw D, B-3590 Diepenbeek, Belgium. | - |
local.uhasselt.international | yes | - |
item.validation | ecoom 2022 | - |
item.fulltext | With Fulltext | - |
item.fullcitation | Monien, Bernhard H.; Bergau, Nick; HOGERVORST, Janneke; NAWROT, Tim; Trefflich, Iris; Weikert, Cornelia & Abraham, Klaus (2021) Detection of a Hemoglobin Adduct of the Food Contaminant Furfuryl Alcohol in Humans: Levels of N-((Furan-2-yl)methyl)-valine in Two Epidemiological Studies. In: MOLECULAR NUTRITION & FOOD RESEARCH, 65(23), (Art N° 2100584). | - |
item.accessRights | Open Access | - |
item.contributor | Monien, Bernhard H. | - |
item.contributor | Bergau, Nick | - |
item.contributor | HOGERVORST, Janneke | - |
item.contributor | NAWROT, Tim | - |
item.contributor | Trefflich, Iris | - |
item.contributor | Weikert, Cornelia | - |
item.contributor | Abraham, Klaus | - |
crisitem.journal.issn | 1613-4125 | - |
crisitem.journal.eissn | 1613-4133 | - |
Appears in Collections: | Research publications |
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Molecular Nutrition Food Res - 2021 - Monien - Detection of a Hemoglobin Adduct of the Food Contaminant Furfuryl Alcohol in.pdf | Published version | 514.16 kB | Adobe PDF | View/Open |
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